Patents Examined by Kevin S Orwig
  • Lactic acid bacteria that co-aggregate with pathogenic bacteria
    Patent number: 9585922
    Abstract: The invention relates to a microorganism, of the order of lactic acid bacteria or analog, fragment, derivative, mutant or combination thereof. Said microorganism, or analog, fragment, derivative, mutants or combinations thereof can be co-aggregated with at least Staphylococcus aureus or Pseudomonas aeruginosa.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: March 7, 2017
    Assignee: ORGANOBALANCE MEDICAL AG
    Inventors: Christine Lang, Andreas Raab, Patrick Golletz
  • Method of making high performance activated aluminum sesquichlorohydrate powders
    Patent number: 9572758
    Abstract: Activated aluminum sesquichlorohydrate (AASCH) powders and method of making are disclosed. The AASCH powder has Al:Cl atomic ratio of from about 1.60 to about 1.90 and Band III polymer concentration of at least about 20% and Band IV polymer concentration of at least about 15% when analyzed with Size Exclusion Chromatogram (SEC) operated by High Performance Liquid Chromatograph (HPLC). The method of making the active comprises (a) diluting the concentrated aluminum sesquichlorohydrate (ASCH) solution to from about 10% to about 25% by weight and (b) heating the diluted solution to obtain a Band III polymer concentration of at least about 20% and a Band IV polymer concentration of at least about 15%, and (c) drying the heated solution to powders having Al:Cl ratio of about 1.60 to about 1.90 and (d) optionally screen or light mill the powders to free flowing spherical particles.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: February 21, 2017
    Assignee: Gulbrandsen Technologies, Inc.
    Inventor: Zijun Li
  • Use of polymeric or oligomeric active ingredients for medical articles
    Patent number: 9572913
    Abstract: The invention relates to the use of polymeric or oligomeric active ingredients having a biocidal effect as additives in the composition of medical articles. The invention further relates to medical articles that comprise such additives.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: February 21, 2017
    Assignee: B. Braun Melsungen AG
    Inventors: André Weiβ, Thomas Riemann, Martin Sippel
  • Bioerodible patch comprising a polyaphron dispersion
    Patent number: 9549896
    Abstract: A bioerodible patch comprising at least one bioadhesive layer and at least one non-bioadhesive layer, wherein the bioadhesive layer comprises at least one polyaphron dispersion and at least one bioadhesive polymer, and wherein the polyaphron dispersion comprises at least one pharmaceutically active agent.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: January 24, 2017
    Assignee: DRUG DELIVERY SOLUTIONS LIMITED
    Inventors: Nigel Crutchley, Steen Sindet-Pedersen, Stephen Lenon
  • Cyclic peptides as ADAM protease inhibitors
    Patent number: 9546198
    Abstract: The invention relates to a method for inhibiting an ADAM protease, comprising inhibiting binding to an integrin-binding loop of a disintegrin domain in the ADAM protease. Also provided are cyclic peptides which inhibit binding to an integrin-binding loop of an ADAM protease, as well as associated pharmaceutical compositions, uses and methods of treatment.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: January 17, 2017
    Assignee: CANCER RESEARCH TECHNOLOGY LIMITED
    Inventors: Joerg Bartsch, Garrit Koller
  • Antimicrobial composition
    Patent number: 9545390
    Abstract: An antiseptic composition suitable for use on skin and wounds comprising a source of an antimicrobial agent and an agent which disrupts biofilms. More, particularly the invention relates to a composition capable of providing effective antimicrobial activity while at the same time avoiding wound and skin irritation and retardation of wound healing.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: January 17, 2017
    Assignee: Convatec Technologies Inc.
    Inventors: Steven L. Percival, Phillip G. Bowler, David Parsons
  • Stable silk protein fragment compositions
    Patent number: 9545369
    Abstract: A composition is disclosed that includes pure silk fibroin-based protein fragments that are substantially devoid of sericin, wherein the composition has an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, wherein the composition has a polydispersity of between about 1.5 and about 3.0, wherein the composition is substantially homogeneous, wherein the composition between 0 ppm to about 500 ppm of inorganic residuals, and wherein the composition includes between 0 ppm to about 500 ppm of organic residuals.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: January 17, 2017
    Assignee: Silk Therapeutics, Inc.
    Inventors: Gregory H. Altman, Rebecca L. Horan, Rachel Lee Dow, Rachel M. Lind, Dylan S. Haas
  • Stable silk protein fragment compositions
    Patent number: 9522108
    Abstract: A composition is disclosed that includes pure silk fibroin-based protein fragments that are substantially devoid of sericin, wherein the composition has an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, wherein the composition has a polydispersity of between about 1.5 and about 3.0, wherein the composition is substantially homogeneous, wherein the composition between 0 ppm to about 500 ppm of inorganic residuals, and wherein the composition includes between 0 ppm to about 500 ppm of organic residuals.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: December 20, 2016
    Assignee: Silk Therapeutics, Inc.
    Inventors: Gregory H. Altman, Rebecca L. Horan, Rachel Lee Dow, Rachel M. Lind, Dylan S. Haas
  • Stable silk protein fragment compositions
    Patent number: 9522107
    Abstract: A composition is disclosed that includes pure silk fibroin-based protein fragments that are substantially devoid of sericin, wherein the composition has an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, wherein the composition has a polydispersity of between about 1.5 and about 3.0, wherein the composition is substantially homogeneous, wherein the composition between 0 ppm to about 500 ppm of inorganic residuals, and wherein the composition includes between 0 ppm to about 500 ppm of organic residuals.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: December 20, 2016
    Assignee: Silk Therapeutics, Inc.
    Inventors: Gregory H. Altman, Rebecca L. Horan, Rachel Lee Dow, Rachel M. Lind, Dylan S. Haas
  • Fentanyl-containing patch for external use
    Patent number: 9517211
    Abstract: A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60wt % of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.
    Type: Grant
    Filed: January 26, 2009
    Date of Patent: December 13, 2016
    Assignee: TEIKOKU SEIYAKU CO., LTD.
    Inventors: Kunihiko Matsushita, Mamoru Naruse, Kenichi Hattori
  • Stable silk protein fragment compositions
    Patent number: 9517191
    Abstract: A composition is disclosed that includes pure silk fibroin-based protein fragments that are substantially devoid of sericin, wherein the composition has an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, wherein the composition has a polydispersity of between about 1.5 and about 3.0, wherein the composition is substantially homogeneous, wherein the composition between 0 ppm to about 500 ppm of inorganic residuals, and wherein the composition includes between 0 ppm to about 500 ppm of organic residuals.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: December 13, 2016
    Assignee: Silk Therapeutics, Inc.
    Inventors: Gregory H. Altman, Rebecca L. Horan, Rachel Lee Dow, Rachel M. Lind, Dylan S. Haas
  • Stable silk protein fragment compositions
    Patent number: 9511012
    Abstract: A composition is disclosed that includes pure silk fibroin-based protein fragments that are substantially devoid of sericin, wherein the composition has an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, wherein the composition has a polydispersity of between about 1.5 and about 3.0, wherein the composition is substantially homogeneous, wherein the composition between 0 ppm to about 500 ppm of inorganic residuals, and wherein the composition includes between 0 ppm to about 500 ppm of organic residuals.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: December 6, 2016
    Assignee: Silk Therapeutics, Inc.
    Inventors: Gregory H. Altman, Rebecca L. Horan, Rachel Lee Dow, Rachel M. Lind, Dylan S. Haas
  • Peptides comprising alternating hydrophobic and anionic amino acids for treatment of osteoporosis
    Patent number: 9457056
    Abstract: The present invention provides methods for prevention, prevention of progression, and treatment of osteoporosis and pre-osteoporotic conditions comprising direct administering to osteoporetic bone of a composition comprising amphiphilic peptides and peptide matrices thereof, useful in promoting biomineralization, local osteoporetic medications and inducing bone repair.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: October 4, 2016
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Hanna Rapaport
  • Cyclic peptide-based NPR-B agonists
    Patent number: 9458198
    Abstract: Disclosed are cyclic, peptide-based novel compounds having NPR-B agonistic activity. Preferred compounds are cyclic peptides containing conventional or non-conventional L- or D-amino acid residues connected to one another via peptide bonds. In some embodiments, provided herein are a cyclic peptide compound with a ring size that is significantly reduced as compared to known NPR-B agonists, such as CNP.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: October 4, 2016
    Assignee: Shire Orphan Therapies GmbH
    Inventors: Frank Osterkamp, Heiko Hawlisch, Gerd Hummel, Tobias Knaute, Ulf Reimer, Ulrich Reineke, Bernadett Simon, Uwe Richter, Edgar Specker, Markus Woischnik, Mark R. Hellberg
  • Injectable bulking compositions
    Patent number: 9415022
    Abstract: According to an aspect of the invention, injectable bulking compositions are provided which contain the following: (a) fibers that are configured to prevent migration to locations in the body remote from the injection site, for example, because they have a minimum length that is sufficiently large to prevent migration of the fibers and/or because they have surface features that stimulate host tissue response to lock the fibers in position and (b) a carrier in an amount effective to render the composition injectable.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: August 16, 2016
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Jianmin Li, Michael Madden
  • Use of anthranilic acid diamide derivatives for pest control in transgenic crops
    Patent number: 9414595
    Abstract: The present invention relates to the use of anthranilic acid diamide derivatives with heteroaromatic and heterocyclic substituents of formula (I) wherein R1, R2, R3, R4, R5, R6, n, A, Q have the meanings as given in the description—for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and to methods particularly useful for controlling insects, and/or acarids and/or nematodes and/or increasing crop yield in those crops.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: August 16, 2016
    Assignees: Bayer CropScience AG, Bayer Intellectual Property GmbH
    Inventors: Rüdiger Fischer, Heike Hungenberg, Bill Striegel, Steven Riniker
  • Peptide compounds that inhibit neuronal exocytosis
    Patent number: 9393187
    Abstract: Compounds of general formula (I): R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zq-R2 (I) their stereoisomers, mixtures thereof, their cosmetically or pharmaceutically acceptable salts and/or its functionally equivalent variants, preparation processes, cosmetic or pharmaceutical compositions which contain them and their use in medicine, particularly in the treatment and/or prevention of pain, inflammation, itching, neurological, compulsive and/or neuropsychiatric diseases and/or disorders and in processes of treatment and/or care of the skin, hair and/or mucous membranes mediated by neuronal exocytosis.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: July 19, 2016
    Assignee: Lubrizol Advanced Materials, Inc.
    Inventors: Antonio Vicente Ferrer Montiel, Gregorio Fernández Ballester, José María García Antón, Cristina Carreño Serraïma, Núria Almiñana Doménech, Raquel Delgado González
  • Photoprotective compositions and films, and a preparation method
    Patent number: 9381383
    Abstract: A photoprotective composition, in particular a cosmetic composition, that includes particles of photonic material having a polymeric multilayer interference structure, where at least two layers of the structure contain an amphiphilic polymer.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: July 5, 2016
    Assignee: L'OREAL
    Inventors: Karine Lucet-Levannier, Jean-Thierry Simonnet, Bertrand Lion
  • Method of making a reinforced absorbable multilayered hemostatic wound dressing
    Patent number: 9358318
    Abstract: The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and/or fibrinogen.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: June 7, 2016
    Assignees: Ethicon, Inc., Omrix Biopharmaceutical, Inc.
    Inventors: Anne Jessica Gorman, Sanyog Manohar Pendharkar
  • Peptide-based collagen modulators for wound healing and tissue repair
    Patent number: 9345744
    Abstract: Provided are peptides that can inhibit collagen synthesis, processing and/or secretion from scar forming cells or fibroblasts. Also provided are methods for using the peptides to produce an anti-fibrotic, anti-scarring, anti-inflammatory, and/or pro-regenerative effect, e.g., on an injured or diseased tissue.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: May 24, 2016
    Assignees: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT, UNIVERSITY OF SOUTH CAROLINA
    Inventors: Robert G. Gourdie, Edie C. Goldsmith, L. Jane Jourdan, Joshua Matthew Rhett, Michael J. Yost