Abstract: A collapsible valve comprising a first portion with at least one dimple in a side thereof, and a second portion, the second portion being narrower than the first portion and arranged along an axial dimension of the first portion, the second portion including a cut therein.

Abstract: Methods, system and devices for monitoring control parameters in a closed loop control operation including continuously monitoring glucose level and automatic administration of a medication, detecting a condition associated with hypoglycemia, determining whether a probability of the detected condition associated with hypoglycemia exceeding a threshold level, and outputting a notification based upon the determination are provided.

Abstract: Some embodiments relate to a luer connector comprising a housing having a hollow bore therethrough, a first end, and a second end, a male luer tip supported by the housing configured to rotate with respect to the housing, the luer tip having a first open end and a passageway through the luer tip in fluid communication with the first open end, and a substantially rigid internal member extending into the passageway of the luer tip toward the first open end of the luer tip. In some embodiments, at least one of the luer tip and the internal member can be axially moveable between a first closed position and a second open position relative to the other of the luer tip and the internal member. Further, the luer tip and the internal member can cooperate such that rotation of the luer tip in a first direction relative to the housing increases an axial displacement between the first open end of the luer tip and an end portion of the internal member.

Abstract: A needle mounting system and methods for mounting a needle assembly on a needle mount are disclosed. The needle mounting system includes a needle hub having protrusions extending radially inward. A needle mount has a plurality of slots to receive the protrusions. The slots have a first portion that defines a passageway substantially parallel to a longitudinal axis of the needle mount and a second portion substantially perpendicular to the axis. The needle hub and mount provide a method wherein a needle assembly may be mounted on an injection device without completely rotating the needle hub relative to the needle mount.

Abstract: A drug infusion system capable of delivering a fluid medication to a patient under direction of a medical professional continually at a basal rate and at an interval rate in each of a plurality of time slots over a specified period of time. The total dose of the fluid medication to be delivered to the patient over the period of time based on the basal rate and the interval rate for each of the plurality of time slots is determined, compared the total dose against a maximum dose. The basal rate is adjusted, if necessary, so that the total dose does not exceed the maximum dose.

Abstract: A device for metered administration of a liquid product including a container for the product, a delivery mechanism which acts on the product located in the container and delivers product from the container by means of an axial output movement in a delivery direction, and an inherently axially rigid housing support structure which supports the container in and counter to the delivery direction, wherein the housing support structure has, over the axial length of the container, an axial thermal expansion coefficient which, within a temperature range in which the device is used, corresponds at least substantially to the axial thermal expansion coefficient of the container.

Abstract: An intravitreal injection system for administering a pharmacological agent formulation to an intravitreal compartment of an eye, comprising (i) an injection member coupled to, or comprising, an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein, (ii) a needle having a first end that is in communication with a formulation chamber and a second injection end, and (iii) a movable platform for positioning the system on the eye, guiding the needle, and limiting the penetration depth of the needle into the eye.

Abstract: Described herein are devices and methods for guide catheters having one or more regions of increased flexibility. A flexibility region comprises one tubular segment of the guide catheter with a non-linear longitudinal seam between two non-concentric layers of material having different durometers. A non-linear seam, such as a zig-zag or sinusoidal configuration, permits controlled compression of lower durometer material between portions of higher durometer material.

Abstract: A controlled volume injection/aspiration device includes a syringe having a body for containing a medicament, a needle and a piston slidably disposed within the body. A shell is provided for receiving the syringe body and a plunger rack is disposed within the shell. A manually operated control is disposed in an operative relationship with the plunger rack for moving the plunger rack in a stepwise forward direction causing the piston to eject discrete doses of medication from the syringe body through the needle. The manual operated control is also operative for moving the piston in a stepwise reverse direction causing the piston to aspirate fluid into the syringe body through the needle.

Abstract: A disposable flow set for use with a pump includes a first administration tube, at least one tube-segment having a first end and a second end, the first end connected to the first administration tube, a second administration tube connected to the second end of the at least one tube-segment; and an identifying key member connected to the at least one tube-segment. The identifying key member includes a number of teeth that define a unique code, including a combination of location and width. The teeth fit into compatible niches located in the pump.

Abstract: A medical needle device includes a winged shield (4) having a substantially cylindrical shaped shield cylinder (4a) and wings (5, 6) connected to the front end side thereof, a needle base (2) inserted in the shield cylinder (4a), and a needle (1). The wings have wing projections (7, 8) and the shield cylinder has through holes (9, 10) on the wall thereof. By overlaying the wings along the side surface of the shield cylinder, each of the wing projections can be inserted into the inner cavity of the shield cylinder via the through hole. Thereby, without requiring a special operation in the sticking operation, each of the wing projections can prevent the needle base from moving in the axial direction and can hold the needle base in the shield cylinder reliably in a state in which the needle protrudes from the front end of the shield cylinder by a predetermined length.

Abstract: An apparatus and method for preventing free flow through an infusion set utilizes an occluder disposed within the infusion set to selectively prevent flow therethrough. The occluder may be responsive to a pressure differential within the infusion set or may respond to compression of the infusion set. When a pair of occluders are used in sequence, an in-line pump may be formed.

Abstract: An apparatus and method for tunneling a distal portion of a multilumen catheter tube in a patient is disclosed. The apparatus includes a connector having a distal end and a proximal end. The proximal end includes a first coupling portion for selective connection to a distal end of the multilumen catheter tube, and the distal end of the connector includes a second coupling portion. A trocar is provided having a first end and a second end. The second end of the trocar is configured for selective connection to the coupling portion of the connector. The connector and the second end of trocar are configured such that they are substantially coaxially aligned with the multilumen catheter tube when the first coupling portion of the connector is selectively joined with the distal end of the multilumen catheter tube and the second end of the trocar is selectively engaged with the second coupling portion of the connector. A method of reverse tunneling a multilumen catheter tube using such an apparatus is also disclosed.

Abstract: A safety needle assembly has a needle hub and a needle cannula projecting from the hub. Wings project transversely from the hub to facilitate manipulation and positioning of the needle assembly. A shield is hingedly attached to the needle hub and can be rotated from a first position where the needle cannula is exposed to a second position where the needle cannula is shielded. At least one latch may be disposed on the shield for secure locked engagement with the hub, the wings and/or the tubing extending from the hub. A spring may also be provided for propelling the shield into the second position.

Abstract: A needle assembly for an intradermal injection device, and a drug delivery device, which includes a needle cannula and a limiter surrounding the needle cannula and includes a skin engaging surface on the limiter. The limiter is moveable from a first position in which an elongate portion of the needle cannula is exposed for access to a medication vial, to a locked second position in which the limiter is not movable from the second position to the first position. In the second position, the needle tip extends beyond the skin engaging surface a distance of about 3 mm or less.

Abstract: A catheter comprising a dual lumen tube with a bolus at its distal end having a bullet nose. A venous port is formed in one side of the bolus adjacent the bullet nose of the bolus. An arterial port is formed in the bolus circumferentially displaced 180° around the catheter from the venous port. The bolus contains a venous passage which transitions from a smaller two-thirds moon shaped cross-section to a larger circular cross-section. The arterial passage has a crescent-moon shaped cross-section. The bullet nose is not as thick as the tube and is inclined on an angle to the axis of the tube so that a portion of its outer periphery is substantially tangent to a hypothetical cylinder containing the trailing edge of the venous port.

Abstract: A safety needle device and positive flush mechanism for use with a vascular access port. In one embodiment, the combination needle assembly includes a needle, a body and a base, the body being collapsible to expunge fluid therefrom as the needle is withdrawn from a vascular access port. In another embodiment, the combination needle assembly includes a needle, a housing and a reservoir, the housing squeezing the reservoir to expunge fluid therefrom as the needle is withdrawn from the port. In another embodiment, the needle assembly includes a compression plate and balloon extension, the compression plate forcing fluid out of the balloon extension as the needle is withdrawn from the port. In all embodiments, the needle assembly is configured to provide a positive flush to overcome negative pressures in the vascular access port, while also providing a locking mechanism to prevent accidental needle sticks.

Abstract: The present invention includes an automatic injection device that reliably provides automatic needle retraction even when manufactured with part and assembly tolerances typical of low-cost and high-volume manufacturing processes. The injector of the present invention includes a body, a syringe cartridge, a drive mechanism, and a bias mechanism. The drive mechanism includes an energy source, a drive member, and a compound plunger with a releasable coupling. Significantly, the compound plunger included in the drive mechanism is designed to ensure needle retraction occurs after the automatic injection device has delivered the desired dose of medicament. Moreover, the design of the compound plunger included in the injector of the present invention can compensate for part and assembly tolerances typical of low-cost, high volume manufacturing processes, enabling the fabrication of a low cost automatic injection device providing reliable automatic needle retraction.

Abstract: An ophthalmic drug delivery device having a first end and a second end, an injection port, a reservoir, and a sleeve is disclosed. The injection port is for sealingly engaging a needle of a syringe, which is for providing a fluid comprising a pharmaceutically active agent. The reservoir is disposed within the device, is fluidly coupled to the injection port, and has an opening for communicating the fluid to an outer surface of a sclera of an eye. The sleeve is for engaging the device proximate overlapping portions of the first end and the second end for forming a generally ring-shaped three-dimensional geometry upon implantation of the device on the outer surface of the sclera. The device is useful for the treatment of a disease of the posterior segment of the eye.

Abstract: An injector system includes a powered injector, a pressurizing chamber in operative connection with the powered injector, a fluid path in fluid connection with the pressurizing chamber, and a manual control in fluid connection with the fluid path. The manual control includes at least one actuator for controlling the injector through application of force by an operator. The actuator provides tactile feedback of pressure in the fluid path to the operator via a fluid connection with the fluid path.