Patents Examined by Kimberly A Aaron
  • High affinity leptins and leptin antagonists
    Patent number: 8969292
    Abstract: Leptin muteins, in particular leptin antagonists, with increased binding affinity to leptin receptor are provided. These compounds as well as pharmaceutical composition comprising them are useful for the treatment of any disorder in which a non-desirable or deleterious activity of endogenous leptin or an altered innate immune response is implicated.
    Type: Grant
    Filed: April 17, 2011
    Date of Patent: March 3, 2015
    Assignees: The Medical Research, Infrastructure, and Health Services Fund of the Tel-Aviv Medical Center, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Arieh Gertler, Eran Elinav, Zamir Halpern