Patents Examined by Komal Saeed
  • Thienopyrrolidinones
    Patent number: 6528653
    Abstract: The invention is directed to substituted thieno[2,3-b]pyrrolidin-5-ones. The compounds are useful as inhibitors of cellular production of tumor necrosis factor (TNF-&agr;) and as antiproliferative agents. These compounds are useful in the treatment or control of neuro-degenerative diseases, cardiovascular diseases, cancer or inflammatory diseases.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: March 4, 2003
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Adrian Liam Gill, William Harris