Patents Examined by Kristin Kay Larson
  • Patent number: 5518914
    Abstract: This invention provides a complex consisting essentially of prealbumin, retinol-binding protein, and a retinoid which binds to retinol-binding protein, wherein the concentration of retinoid in the complex is from about 2.times.10.sup.-5 M to about 10.sup.-10 M and the concentration of prealbumin and retinol-binding protein is sufficient to maintain the retinoid concentration from about 2.times.10.sup.-5 M to about 10.sup.-10 M. This invention also provides a composition for enhancing the growth of human B cells in culture which comprises an amount of the complex of this invention effective to enhance the growth of human B cells and a nutrient medium. This invention further provides a method of enhancing growth of human B cells in culture comprising growing the cells in culture in a growth medium containing a concentration of the complex effective to enhance growth of the cells.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: May 21, 1996
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Jochen Buck, Urlich Hammerling
  • Patent number: 5330752
    Abstract: Compositions and methods useful in destroying residual oxidative disinfectant, e.g., used to disinfect a contact lens, are disclosed. In one embodiment, the method comprises contacting an oxidative disinfectant-containing liquid medium with a material selected from glutathione, oxidized glutathione and mixtures thereof, and a co-factor selected from nicotinamide adenine dinucleotide phosphate, nicotinamide adenine dinucleotide and mixtures thereof in the presence of glutathione reductase in an amount effective to promote the oxidation of the co-factor.
    Type: Grant
    Filed: September 21, 1993
    Date of Patent: July 19, 1994
    Assignee: Allergan, Inc.
    Inventors: John Y. Park, James N. Cook
  • Patent number: 5272074
    Abstract: Surfaces of polymeric materials are coated with a layer of thermally denatured fibrinogen. The fibrinogen may be treated with thrombin to produce fibrin, and additional fibrinogen and factor XIII added to produce a cross-linked fibrin coating. The resulting coated surface is stable, anti-thrombotic and resistant to platelet adhesion. Polymeric materials coated in this way are useful in constructing vascular grafts and prosthetic devices, and provide test systems useful in the study of thrombogenesis.
    Type: Grant
    Filed: April 23, 1992
    Date of Patent: December 21, 1993
    Assignee: McMaster University
    Inventor: Fraser D. Rubens