Patents Examined by Kristin Vajda
  • Antimicrobial composition
    Patent number: 11331289
    Abstract: The present invention relates to a new topical composition comprising niclosamide and/or oxyclozanide and to the use of said composition for the treatment or prevention of pyoderma or dermatitis in non-human mammals.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: May 17, 2022
    Assignees: CEVA SANTE ANIMALE, UNION THERAPEUTICS A/S
    Inventors: Jérôme Guyonnet, Claudine Zemiriline, Pascal Butty
  • Ophthalmic composition containing clathrated antioxidant substance, and use thereof
    Patent number: 11331282
    Abstract: The present invention provides an ophthalmic composition and a use thereof. In one embodiment of the present invention, an ophthalmic composition containing a clathrated antioxidant substance is provided. In some of embodiments of the present invention, a composition for treating or preventing an ophthalmic disease, an ophthalmic disorder or an ophthalmic symptom is provided, wherein the ophthalmic disease, the ophthalmic disorder or the ophthalmic symptom includes, but is not limited to, dry eye or a dry eye-like ophthalmic disease, conjunctivitis, corneal ulcer, age-related macular degeneration, cataract, pseudoexfoliation syndrome, and symptoms in these diseases which can be ameliorated by increasing the quantity of tears and/or goblet cells and/or mucin.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: May 17, 2022
    Inventors: Junwen Qin, Yuji Takahashi, Shigeru Kakuta, Shigeru Kyuwa
  • Nanoemulsions and methods for cancer therapy
    Patent number: 11332494
    Abstract: An oxysterol or oxysterol-like compound is provided, which finds use in treating and/or targeting cancer.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: May 17, 2022
    Assignee: Fernando Thome Kreutz
    Inventor: Fernando Thome Kreutz
  • Methods and compositions for modulating splicing
    Patent number: 11326165
    Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: May 10, 2022
    Assignee: SKYHAWK THERAPEUTICS, INC.
    Inventors: Michael Luzzio, Kathleen McCarthy, William Haney
  • Small molecule inducers of autophagy
    Patent number: 11325898
    Abstract: Small molecule disruptors of Beclin-1/Bcl-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 10, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jef De Brabander, Qiren Liang, Beth Levine, Wei-Chung Chiang
  • IRAK degraders and uses thereof
    Patent number: 11318205
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: October 16, 2020
    Date of Patent: May 3, 2022
    Assignee: KYMERA THERAPEUTICS, INC.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Fluge, Matthew M. Weiss, Yi Zhang
  • Pulmonary hypertension treatment
    Patent number: 11318331
    Abstract: Disclosed herein is a therapeutically active agent usable in the treatment of pulmonary arterial hypertension (PAH), for use in the treatment of pulmonary arterial hypertension, as well as methods of treating PAH, said treatment and methods comprising administering such an active agent and effecting pulmonary artery denervation in the subject. In some aspects, a sub-therapeutically effective amount of the active agent is administered. In some aspects, the method is devoid of administering such an active agent for at least one month subsequent to the denervation. Further disclosed is a method of treating PAH comprising determining a responsiveness of the subject to at least one therapeutically active agent usable in treating PAH; and effecting pulmonary artery denervation in a subject responsive to the active agent(s).
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: May 3, 2022
    Assignee: Sonivie Ltd.
    Inventors: Or Shabtay, Dalit Shav
  • Diorganylphosphinic acid salts, method for the production thereof and the use thereof
    Patent number: 11312910
    Abstract: The invention relates to diorganylphosphinic salts containing 0.0001% to 99.9999% by weight of iron, to a process for preparation thereof and to the use thereof.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: April 26, 2022
    Assignee: Clariant International Ltd
    Inventors: Harald Bauer, Sebastian Hörold, Martin Sicken
  • Compositions and methods for modulating hair growth
    Patent number: 11312714
    Abstract: The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: April 26, 2022
    Assignee: The Regents of the University of California
    Inventors: William E. Lowry, Michael E. Jung, Heather R. Christofk, Xiaoguang Liu, Aimee Flores
  • Use of H3K9me3 modulation for enhancing cognitive function
    Patent number: 11311551
    Abstract: Use of H3K9me3 modulation for enhancing cognitive function and treating anxiety related disorders is presented. A composition is administered to the subject comprising a therapeutically effective amount of a SUV39H1 inhibitor comprising analogs of ETP69. The therapeutically effective amount is effective in treating cognitive dysfunction in aging and age-related disorders.
    Type: Grant
    Filed: October 16, 2020
    Date of Patent: April 26, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Carl W. Cotman, Larry E. Overman, Shikha Snigdha
  • Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HTserotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease
    Patent number: 11304932
    Abstract: The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment and prophylaxis of visual hallucinations associated with Lewy Body dementia.
    Type: Grant
    Filed: November 20, 2020
    Date of Patent: April 19, 2022
    Assignee: Axovant Sciences GmbH
    Inventors: Lawrence Tim Friedhoff, Shankar Ramaswamy, Yandong Wen
  • 3-(5-amino-pyrazin-2-yl)-benzenesulfonamide derivatives and related compounds as PI3K-gamma kinase inhibitors
    Patent number: 11306079
    Abstract: This application relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-? which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: April 19, 2022
    Assignee: Incyte Corporation
    Inventors: Artem Shvartsbart, Andrew P. Combs, Nikoo Falahatpisheh, Padmaja Polam, Lixin Shao, Stacey Shepard
  • Isocyanate production method
    Patent number: 11306055
    Abstract: An isocyanate production method is characterized by having: a carbamation step in which a carbonic acid ester, an inorganic acid salt of an amino acid derivative, and a basic compound are reacted to obtain a reaction mixture containing a carbamic acid ester derived from the carbonic acid ester, a hydroxy compound derived from the carbonic acid ester, and the carbonic acid ester; and a thermal decomposition step in which the carbamic acid ester is subjected to a thermal decomposition reaction to obtain an isocyanate.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: April 19, 2022
    Assignee: ASAHI KASEI KABUSHIKI KAISHA
    Inventors: Nobuhisa Miyake, Yuji Kosugi, Yusuke Sakurai, Masaaki Shinohata
  • Magnesium compositions and methods of use
    Patent number: 11298330
    Abstract: The present invention provides a method of administering magnesium threonate to a subject in need of supplementing magnesium. At least a portion of magnesium (Mg) and threonate (T) is present in a salt form of MgT2. The method may comprise administration of magnesium threonate at two different time points per day. The method may comprise administering, at a first time point, a first oral dosage form comprising magnesium threonate. The method may comprise administering, at a second time point, a combination of the first oral dosage form and a second oral dosage form comprising magnesium threonate. The first and second oral dosage forms may exhibit different dissolution profiles in a dissolution medium.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: April 12, 2022
    Assignee: Neurocentria, Inc.
    Inventors: Guosong Liu, Fei Mao, Jason Weinger
  • Ophthalmic compositions of brinzolamide
    Patent number: 11298360
    Abstract: The present invention relates to an aqueous ophthalmic solution for treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma, the solution comprising at least 0.5 w/v % brinzolamide dissolved in the solution; hydroxy-propyl-?-cyclodextrin; polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer; and water and/or the process for preparation thereof.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: April 12, 2022
    Inventors: Saraganachari Andanayya, Narayanaswamy Abhilash, Sreenivasa Reddy, Shivakumar Pradeep
  • Preparation method of a cyclic phosphonate compound
    Patent number: 11292805
    Abstract: A method for preparing the cyclic phosphonate compound of Formula I is described. The method significantly improves the stereoselectivity of the compound with the required configuration.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: April 5, 2022
    Assignee: GANNEX PHARMA CO., LTD.
    Inventors: Jinzi Jason Wu, Bailing Yang, Bin Liang
  • Process for preparing aminopyrimidine derivatives
    Patent number: 11286253
    Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additional, the present invention provides novel intermediates useful for said process and processes for preparing the same.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: March 29, 2022
    Assignee: Yuhan Corporation
    Inventors: Sang-Ho Oh, Ja-Heouk Khoo, Jong-Chul Lim, Seong-Ran Lee, Hyun Ju, Woo-Seob Shin, Dae-Gyu Park, Su-Min Park, Yoon-Ah Hwang
  • Oxysterols and methods of use thereof
    Patent number: 11279730
    Abstract: Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3 and R6, R11a, and R11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: March 22, 2022
    Assignee: SAGE THERAPEUTICS, INC.
    Inventors: Francesco G. Salituro, Albert Jean Robichaud, Gabriel Martinez Botella, Boyd L. Harrison, Andrew Griffin, Daniel La
  • Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof
    Patent number: 11279719
    Abstract: Novel C-2-substituted bicyclic compounds of Formula I have been prepared and found to be useful as inhibitors of by inhibiting geranylgeranylation of proteins. The application is directed to these compounds, to compositions comprising these compounds and to their use, in particular as medicaments to cancer and other conditions treatable by inhibiting human geranylgeranylation pyrophosphate hGGPPS activity.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: March 22, 2022
    Inventors: Youla S. Tsantrizos, Michael Sebag
  • Method of regulating immunity in the intestines
    Patent number: 11278507
    Abstract: Methods for stimulating the G protein receptor (Gpr91) pathway in intestinal cells to release IL-25 and enhance a type II immune response in the subject are useful in the treatment or prevention of bacterial or parasitic infection. Similarly methods and compositions used therein to inhibit or stimulate GPR91 are useful for the treatment or inhibition of certain diseases, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and Crohn's disease.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: March 22, 2022
    Assignee: Monell Chemical Senses Center
    Inventors: Peihua Jiang, Weiwei Lei