Abstract: A product for mitigating the ill-effects of post-coital discharge, post-medical-procedure discharge, and post-urination discharge in men. A sleeve-like pouch includes an inside and an outside, with a top layer disposed on the inside of the sleeve-like pouch, and a bottom layer disposed on the outside of the sleeve-like pouch. An absorbent layer is disposed between the top layer and bottom layer. The sleeve-like pouch is configured to be slid onto and securely surround a male appendage.

Abstract: A bowel movement detection and alerting system including a sensing device attached to an absorbent article for alerting a caregiver to the presence of solid waste by analyzing the gasses expelled in the absorbent article during a bowel movement. The system comprises an elongated pipe made of a flexible material and attached to the absorbent article. The pipe is connected to a gas sensor disposed in a pod device that detects a presence of hydrogen sulfide gas to determine an occurrence of a bowel movement or defecation in the absorbent article.

Abstract: An absorbent article which can have an improved feeling of comfort next to the skin of the wearer and a reduction in the feelings of wetness and rewet. An absorbent article can have a longitudinal direction, a transverse direction, and a depth direction. The absorbent article can have a topsheet layer, a backsheet layer, and an absorbent core positioned between the topsheet layer and the backsheet layer. The topsheet layer can have a hydrophilic central layer, a semi-hydrophilic first side layer, and a semi-hydrophilic second side layer. Each of the semi-hydrophilic side layers can be bonded to the central layer utilizing an embossing technique in the regions of overlap of each of the semi-hydrophilic side layers with the central layer. The area of the body-facing surface of each of the regions of overlap can contain from about 10% to about 35% of at least one embossment.

Abstract: Methods of treatment and pharmaceutical formulations configured to treat primary and secondary mitochondrial dysfunction are provided. The methods and treatments use an agonist of AMPK. The agonist activates AMPK to activate ATP-producing pathways and inhibiting ATP-consuming pathways, thus allowing for the alleviation of symptoms associated with mitochondrial dysfunctions.

Abstract: A process can be used for manufacturing (S)-3-hydroxy-1-(1H-indol-5-yl)-2-oxo-pyrrolidine-3-carboxylic acid 3,5-difluoro-benzylamide.

Abstract: The present application relates to psilocin derivatives of Formula (I), to processes for their preparation, to compositions comprising them and to their use in activation of a serotonin receptor in a cell, as well as to treating diseases, disorders or conditions by activation of a serotonin receptor in a cell.

Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a SHP-2 inhibitor and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.

Abstract: Systems and methods for performing aspiration thrombectomy. The aspiration catheter assembly can include a support catheter and an aspiration catheter extending through the support catheter. The catheter assembly can include a distal valve apparatus that can control a level of vacuum at a distal end of the catheter system. Irrigation can flow between the support catheter and the aspiration catheter to flush the catheter assembly.

Abstract: The subject invention provides a method for treating Parkinsonism or symptoms thereof by low dose pridopidine.

Abstract: Devices can be implanted in an eye to treat a dry eye condition. The devices include a body defining a lumen and having first and second ends and external and lumenal surfaces. The body has a length sufficient to provide fluid communication between the anterior chamber and tear film of the eye through the lumen when the device is implanted in the sclera. In some embodiments, the device is filterless. In some embodiments, a filter is included. The dry eye treatment devices provided herein prevent bacterial ingress, provide outflow resistance to retain a normal intraocular pressure, and provide moisture (e.g., aqueous humor) to an otherwise dry eye. Methods of treating a dry eye condition wherein the device is implanted in the sclera of an afflicted eye are also described.

Abstract: A valve member for a connector includes a head portion, a body portion, and a circumferential lip seal extending radially outward from an outer surface of the head portion. The head portion includes a top section defining a first seal portion. The body portion extends longitudinally from the head portion and defines a second seal portion at a proximal end thereof. The second seal portion is disposed distally to the first seal portion. The circumferential lip seal is disposed between the first and second seal portions.

Abstract: The present disclosure relates to a diffusion device, such as a blood oxygenator or gas exchanger, having improved flow characteristics.

Abstract: A disposable diaper in which an absorbent body (7) is provided on a crotch part of a pants-shaped exterior member (2), wherein the absorbent body (7) is adhered to a skin-facing side of the exterior member (2) at a first adhering region (14), an inner sheet (5) and an outer sheet (6) of the exterior member (2) are adhered to each other at a second adhering region (16), the second adhering region (16) includes a second middle adhering region (16M) provided at the crotch part, a second front adhering region (16F) located anterior thereto and a second rear adhering region (16B) located posterior thereto, the second front adhering region (16F) and/or the second rear adhering region (16B) is provided intermittently from one side edge to the other side edge, with respect to the width direction, of the absorbent body (7), and a second front non-adhering region (17F) and/or a second rear non-adhering region (17B) is formed at a portion which the absorbent body (7) is overlapped with and is provided so as to overlap w

Abstract: A disposable absorbent underwear product includes a garment layer, an absorbent insert, a non-woven patch, and a barrier. The absorbent insert has a fluid-impermeable base layer, an absorbent core, and a fluid-permeable top layer. The non-woven patch covers an end of the absorbent insert. A first portion of the non-woven patch is adhered to both the fluid-permeable top layer of the absorbent insert and the garment layer with an adhesive. A second portion of the non-woven patch is free and forms a pouch. An end portion of the absorbent core is disposed adjacent to the second portion of the non-woven patch. The barrier extends along a width of the absorbent insert. The barrier extends through the fluid-permeable top layer of the absorbent core and connects the fluid-impermeable base layer and the one non-woven patch to direct fluid flow to the absorbent core and militate against fluid overflow.

Abstract: In one aspect, the invention provides compounds of Formula I, and salts, hydrates and isomers thereof. In another aspect, the invention provides a method of promoting bone formation in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides orthopedic and periodontal devices, as well as methods for the treatment of renal disease, diabetes, bone loss, and cancer, using a compound of Formula I.

Abstract: A fluid collection system may include a fluid collection device, a tube, a fluid collection container configured to receive fluid from the fluid collection device, and a vacuum source configured to pull an at least partial vacuum to draw the fluid from the fluid collection device through the tube into the fluid collection container. The fluid collection device may include a fluid impermeable barrier including an outer surface and an inner surface, the fluid impermeable barrier defining a chamber, at least one opening, and a fluid outlet. The fluid collection device may include a porous material disposed in the chamber and an external support coupled to the outer surface of the fluid impermeable barrier. The fluid impermeable barrier exhibits a first shape prior to shaping the external support and a second shape after shaping the external support with the first shape being different from the second shape.

Abstract: An absorbent article (10) has a front region (20), a back region (30), and a crotch region (40) extending between and connecting the front region (20) and the back region (30). The absorbent article (10) can have non-linear leg edges (82, 84) extending between and connecting the front region (20) and the back region (30). The absorbent article (10) can have an absorbent article (10) narrowest width (80) positioned between the waist edge (22) of the front region (20) and the transverse axis (14) of the absorbent article (10). A non-linear leg elastic (140) can extend from one side edge (34) of the back region (30) to another side edge (36) of the back region (30) and can have an apex (142) located between the absorbent article (10) narrowest width (80) and the transverse axis (14).

Abstract: Substituted benzoxazole and benzofuran chemical entities of Formula (I): wherein, V, W, X, Y, Z, and m have any of the values described herein and compositions comprising such chemical entities; processes for making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; and the treatment of one or more disorders, including neurological, cognitive, immunological, and inflammatory disorders, as well as other conditions and diseases involving PDE7 or cyclic nucleotide signaling.

Abstract: The invention relates to a wearable article comprising an elastic laminate. The elastic laminate comprises a first web and a second web being in a face to face relationship with each other. The first web is a nonwoven web having a vertical wicking height after 60 seconds of less than 5 mm according to the test method set out herein. The second web is a nonwoven web having a vertical wicking height after 60 seconds of at least 5 mm.

Abstract: An artificial lung device includes: a housing which is formed in a tubular shape including both end portions closed, includes a blood inflow port and a blood outflow port, and is arranged such that a center axis of the housing is directed in a lateral direction; a hollow fiber body (gas exchanger) which is arranged in the housing and performs gas exchange with respect to blood while the blood flows from the blood inflow port to the blood outflow port; and a straightening frame (gas guide portion) by which a gas having flowed through the gas exchanger by the flow of the blood is guided to the gas exchanger again in the housing.