Patent number: 5438131
Abstract: Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each R.sub.n is H, OH, F or OCH.sub.3 ;Z is a member of the group consisting of O, S and CH.sub.2 ; andB is a five-membered, heterocyclic base having at least two double bonds, and further having an electron withdrawing group bonded thereto, said base with electron withdrawing group being represented by the formula: ##STR2## wherein: said base with electron withdrawing group is bonded at X.sub.4 to the sugar portion of the nucleoside;X.sub.1, X.sub.3 and X.sub.5 are each members of the group consisting of N, O, C, S and Se;X.sub.2 and X.sub.4 are each members of the group consisting of N and C; andW is a member of the group consisting of F, Cl, Br, I, O, S, OH, SH, NH.sub.2, NO.sub.2, C(O)H, C(O)NHOH, C(S)NHOH, NO, C(NOCH.sub.3)NH.sub.2, OCH.sub.3, SCH.sub.3, SeCH.sub.3, ONH.sub.2, NHOCH.sub.
Type:
Grant
Filed:
September 16, 1992
Date of Patent:
August 1, 1995
Inventors:
Donald E. Bergstrom, Philip C. Andrews, Ruthann Nichols, Peiming Zhang
Patent number: 5405944
Abstract: There are described novel glycosides of catechol estrogen, a method of preparing the same, and a medicament comprising one of the glycosides as an active ingredient. The glycosides are shown by the formula of ##STR1## wherein X is carbonyl group or ##STR2## R.sub.10 is hydroxyl group or glycosyloxy group, and R.sub.2 is a hydrogen atom or ethynyl group; R.sub.11 is a hydrogen atom, hydroxyl group, or glycosyloxy group; R.sub.12 is hydroxyl group or glycosyloxy group; and R.sub.13 is hydroxyl group or glycosyloxy group,in which glycosyloxy group is selected from the group consisting of glucosyloxy, galactosyloxy, mannosyloxy, arabinosyloxy, ribosyloxy, xylosyloxy, fructosyloxy, rhamnosyloxy, fucosyloxy, maltosyloxy, cellobiosyloxy, lactosyloxy, sucrosyloxy, maltotriosyloxy, maltotetraosyloxy, maltopentaosyloxy, maltohexaosyloxy, maltoheptaosyloxy, and sialosyloxy, and in this case, at least one of R.sub.10, R.sub.11, R.sub.12, and R.sub.13 is glycosyloxy group as defined above.
Type:
Grant
Filed:
September 25, 1992
Date of Patent:
April 11, 1995
Assignee:
Institute of Applied Biochemistry
Inventors:
Takehiko Suzuki, Sadaaki Komura, Naoko Ishida, Nobuko Ohishi, Kunio Yagi