Abstract: Novel hydrogel formulations useful as adhesive reservoirs for topical or transdermal drugs employ as the polymer base a crosslinked polymer or copolymer of 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof. The gels are prepared from polymerizable compositions comprising:20%-50% of a monofunctional monomer component, at least 75% of said component comprising 2-acrylamido-2-methylpropane sulfonic acid or a salt thereof, the balance being selected from the group consisting of acrylic acid, water soluble acrylic functional monomers and vinyl pyrrolidone;30%-50% of a glycol component selected from the group consisting of compounds of the formulaHO--(C.sub.2 H.sub.4 O).sub.n --H,HO--(C.sub.3 H.sub.6 O).sub.m --Hand mixtures thereof, where n is in the range of about 4 to about 16 and m is 1-4;between about 0.02% and about 0.

Abstract: The present invention relates to a pharmaceutical composition in a form of a film. The composition comprises (a) a butyrophenone compound and (b) a vehicle comprising polyvinyl acetal diethylaminoacetate and polyvinyl pyrrolidone. The ratio of the compound to the vehicle is from 1% to 80% by weight based on the total weight of the vehicle and the ratio by weight of polyvinyl acetal diethylaminoacetate and polyvinyl pyrrolidone is from 1:9 to 9:1. The pharmaceutical composition can be applied to the skin of a patient for a long time and maintain a therapeutically effective blood level of the butyrophenone.

Abstract: A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug.

Abstract: A method for treating angina, epilepsy and hypertension by achieving vasodilation, anti-angina or anti-convulsant effect in a patient is described. The method involves transdermally administering to a patient in need of vasodilation or anti-convulsant effect the compound known as (+)(2S,3S)-acetoxy-8-chloro-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-meth oxyphenyl)-1,5-benzothiazepin-4-(5H)-one in an amount sufficient to achieve desired systemic vasodilation, anti-angina or anti-convulsant levels of the compound.

Abstract: An adhesive for percutaneous administration having a drug-containing layer composed of a base component mainly comprising a heat-sensitive and water-sensitive amphiphilic polymer and a drug incorporated in the base component. The amphiphilic compound has a characteristic hydrophobicity-hydrophilicity tapered structure, and a variety of liquid or solid or lipophilic (hydrophobic) or hydrophilic drugs of a broad range can stably be dissolved or dispersed therein. The drug in the drug-containing layer remains stable without being released or diffused while the adhesives are stored, and upon application to the skin, the drug is gradually released and diffused into the skin with high availability in a specifically controlled pattern. The present adhesive is especially advantageous for endermic presentation of a slight amount of a substance of high physiological activity which is unstable and is easily decomposed by heat or water.

Abstract: A non-gritty chewable calcium tablet comprising a granulation having a bulk density of about 0.3 g/ml to about 1.5 g/ml, said granulation comprising micronized calcium citrate, a sweetener and a lubricant. The calcium particle size is in the range of about 0.1 micronmeters to about 10 micronmeters.

Abstract: Chewable medicament tablets are made from coated granules of medicament wherein the coating on said granules comprises a blend of cellulose acetate or cellulose acetate butyrate and polyvinyl pyrrolidone.

Abstract: A diffusional drug delivery device is described which can provide for stability of the adhesive and system components, elimination of the initial burst of drug and hence irritation, and to provide for delayed onset of therapeutic effect along with delivery of a therapeutic agent at an optimum rate. The therapeutic agent in a first form which is suitable for storage, and the anhydrous activating means are inert when in an anhydrous environment. Moisture activates the system whereby the activating means provides an acidic or basic solution and the first form of the therapeutic agent is converted to a second form which is suitable for absorption through the skin or mucosa.

Abstract: A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.