Abstract: Lack of safety and efficacy are the two major unwanted biological responses that play as critical bottlenecks for the success of drug candidates in drug discovery and development. Conventional systems and methods involve ineffective exploration and use of chemical information space and thereby, may fail to address safety and efficacy issues. Embodiments of the present disclosure provides an effective solution to the above bottle-necks with the effective exploration/search of chemical information space using effective statistical techniques that yield meaningful chemical information comprising relevant descriptors, fingerprints, fragments, optimized set of structural images, and the like. Further, it provides robust predictive models for the biological response, example renal toxicity using the selected chemical information in an automated manner for a given experimental data and alerts/rules that can be successfully employed to address failures of drug candidates during discovery and development.

Abstract: A liquid discharge method of discharging a liquid from a nozzle of a liquid discharge head by applying a drive pulse to a drive element of the liquid discharge head includes an acquisition step of acquiring a state of a dot formed on a recording medium by the liquid discharged from the nozzle, as a recording condition, and a driving step of applying the drive pulse that varies depending on the recording condition acquired in the acquisition step, to the drive element. The drive pulse may include a first potential, a second potential different from the first potential, and a third potential different from the first potential and the second potential. The second potential may be to be applied after the first potential, and the third potential may be to be applied after the second potential.

Abstract: In a head substrate according to an embodiment of the present invention comprises a plurality of nozzles for discharging liquid; a plurality of electrothermal transducers corresponding to the plurality of nozzles; and a plurality of drivers corresponding to the plurality of electrothermal transducers, the substrate has the following configuration. Specifically, it comprises a detection circuit that detects, in a case where one of the plurality of electrothermal transducers is selected, a temperature of the selected transducer to which a first signal is applied to in order to discharge a liquid from a nozzle corresponding to the selected electrothermal transducer, and then a second signal is applied to heat the selected electrothermal transducer.

Abstract: A recording device includes a recording head and a control unit. When recording a raster line forming a partial image of a image, using, of a nozzle row, a plurality of OL nozzles in a positional relationship to record a common raster line, the control unit performs recording using the OL nozzles of a first range, in a range of the OL nozzles in a first direction, when a recording condition is a first recording condition, and performs recording using the OL nozzles of a second range narrower than the first range, of the range of the OL nozzles in the first direction, when the recording condition is a second recording condition in which a density difference, in the image, between the partial image and an image other than the partial image is greater than in the first recording condition.

Abstract: A synthesis machine for preparation of a targeted inorganic material for recommended synthesis by a computer program that determines optimal solid-state methods for synthesis of an inorganic material. The computational method involves inputting a target inorganic material, querying structural data and thermodynamic data for the target inorganic material, enumerating possible synthetic reactions to construct a synthetic reaction database with a viable subset of the possible synthetic methods. The routine generates a nucleation metric and competition metric that are combined to provide recommended synthetic methods. The output for each of the recommended syntheses are input into a robotic synthesis machine where the delivery of reactants, reaction conditions, and analysis of extent of reaction, and product quality is controlled by a processor.

Abstract: According to one embodiment, a control circuit for an inkjet head or the like includes an input circuit configured to receive drive information for driving liquid ejection from a plurality of nozzle arrays. The drive information includes a drive signal value to be supplied to a channel of the plurality of nozzle arrays. A latch circuit array of the control circuit has latch circuits for storing the drive information for each array in the plurality of nozzle arrays. A setting register is configured to receive a setting value to configure the input circuit to correspond to a connection mode for the plurality of latch circuits. The setting value corresponds to the number of arrays in the plurality of nozzle arrays.

Abstract: A liquid ejection device includes a first head unit that includes a plurality of first ejection portions, a second head unit that includes a plurality of second ejection portions, a head controller that controls the first head unit and the second head unit, and a signal path via which determination information indicating whether or not a liquid ejection state of one first ejection portion among the plurality of first ejection portions is abnormal is transmitted from the first head unit to the second head unit without passing through the head controller.

Abstract: A printing apparatus includes one or more memories, and one or more processors that execute a set of instructions to transmit information for identifying print data to a different printing apparatus, receive a print request including print data, store the print data included in the received print request in the memories, and print data, wherein, in a case where the received print request is a print request transmitted from the different printing apparatus, the print data included in the received print request is printed without being stored in the memories.

Abstract: A memory circuit for a print component including plurality of I/O pads, including a first analog pad and a second analog pad, to connect to a plurality of signal paths which communicate operating signals to the print component, including an analog signal path connected to the first analog pad and the second analog pad, the first analog pad electrically isolated from the second analog pad to interrupt the analog signal path to the print component. The memory circuit further includes a memory component to store memory values associated with the print component, and a control circuit to, in response to a sequence of operating signals received by the I/O pads representing a memory read, provide an analog signal to the analog pad to provide an analog electrical value at the analog pad representing stored memory values selected by the memory read.

Abstract: An integrated circuit to drive a plurality of fluid actuation devices includes an ID line, a fire line, a discharge path, a memory element, and a latch. The memory element is electrically coupled to the fire line and the discharge path. The latch disables the discharge path in response to a first logic level on the ID line and enables the discharge path in response to a second logic level on the ID line.

Abstract: An element substrate according to an embodiment of the present invention includes a plurality of print elements and a plurality of drive elements for driving the plurality of print elements. The element substrate comprises a generation circuit configured to generate a first drive signal that drives drive elements belonging to a first group among the plurality of drive elements, and a second drive signal that drives drive elements belonging to a second group among the plurality of drive elements, using a selector configured to switch a signal transmitted from outside of the element substrate and an output destination of the signal within one block period in driving the plurality of drive elements by dividing the plurality of elements into the plurality of blocks. The first drive signal and the second drive signal are generated at different timings.

Abstract: In an image forming apparatus, a control unit (a) sets an ink residual estimation value of a subtank as a first reference value corresponding to a tank capacity of the subtank when ink empty is detected on an ink container, and determines whether the ink residual estimation value is less than the ink consumption estimation value of a subsequent page in a print job or not, and (b1) stops the print job if the ink residual estimation value is less than the ink consumption estimation value of the subsequent page and (b2) continues the print job if the ink residual estimation value is equal to or larger than the ink consumption estimation value of the subsequent page.

Abstract: It is disclosed an amplifier for driving a capacitive load, comprising an input terminal adapted to receive an input voltage signal, an output terminal adapted to drive the capacitive load, a linear amplification stage, switching amplification stage, a capacitor, a first switch and a measurement and control circuit. The measurement and control circuit is configured to: measure the value of the current generated at the output from the linear amplification stage and generate a driving voltage signal of the switching amplification stage; generate the first switching signal to open the first switch and generate an enabling signal to enable the operation of at least part of the switching amplification stage; generate the first switching signal to close the first switch and generate the enabling signal to disable the operation of the switching amplification stage; generate the first switching signal to open the first switch.

Abstract: In an image forming apparatus, a control unit (a) sets an ink residual estimation value of a subtank as a first reference value corresponding to a tank capacity of the subtank when ink empty is detected on an ink container, and determines whether the ink residual estimation value is less than the ink consumption estimation value of a subsequent page in a print job or not, and (b1) stops the print job if the ink residual estimation value is less than the ink consumption estimation value of the subsequent page and (b2) continues the print job if the ink residual estimation value is equal to or larger than the ink consumption estimation value of the subsequent page.

Abstract: An information processing method is performed by a computer for evaluating flammability of a mixed refrigerant material containing a plurality of components. The method includes: calculating, for each of the plurality of components, a second value obtained by multiplying a mixture ratio thereof in the mixed refrigerant material by a first value obtained based on numbers of hydrogen atoms, halogen atoms, and double bonds included in a molecular structure thereof; calculating a total sum of the second value calculated for each of the plurality of components; and classifying the mixed refrigerant material into a predetermined flammability class based on the total sum.

Abstract: According to an aspect of the present invention, an inkjet printing apparatus includes a print head having an ejection opening surface on which ejection openings for ejecting ink are formed, a tank storing ink to be supplied to the print head, a supply flow path for supplying the ink from the tank to the print head, a collection flow path for collecting the ink from the print head to the tank, a supply pump provided in the supply flow path to supply the ink from the tank to the print head, a tank decompression pump which decompresses the inside of the tank, and a control unit which controls to drive the supply pump and the tank decompression pump to fill the collection flow path with ink.

Abstract: An information processing device includes a storage portion storing a learned model, a reception portion receiving air pressure information and temperature information at a time of ejecting ink, and a processing portion controlling a pressurization pump based on the received air pressure information and temperature information and the learned model. The learned model is a learned model trained by performing machine learning of a condition of a pressurization force with which a determination that an ejection failure does not occur is made, based on a data set in which the air pressure information in a usage environment of a printing apparatus including a printing head, the temperature information in the usage environment, and pressurization force information about the pressurization pump supplying the ink to the printing head are associated.

Abstract: A device for printing information at multiple predetermined positions of a flat object including a registration wall, a print module including print nozzles and a print plate and displaceable along an horizontal axis perpendicular to the registration wall, fixed upper drive members for moving the flat object in a direction of transport along the registration wall, the print plate and the fixed upper drive members together forming an upper reference in a vertical direction, and lower pressing members for pressing the flat object against the upper reference, the device further comprises at least one mobile upper drive member and, for avoiding contact with the flat object immediately after printing, the at least one mobile upper drive member is vertically mobile and configured to be moved from a lower to an upper position above the upper reference when the displaceable print module is positioned along the horizontal axis ahead of the at least one mobile upper drive member in the direction of transport.

Abstract: A compensation method includes determining position information of an abnormal nozzle of an inkjet head; acquiring printing parameters, determining first data corresponding to the abnormal nozzle, and based on the position information of the abnormal nozzle and the printing parameters, determining position information of a compensation nozzle for compensating the first data corresponding to the abnormal nozzle; and based on the printing parameters, acquiring second data of the compensation nozzle in a normal printing state which includes ink out data and ink holding data, determining an address of the ink holding data, and generating compensation data by writing the first data into the address of the ink holding data. A compensation device includes: an abnormal nozzle position determination module; a compensation nozzle position determination module; and a compensation data generation module. An inkjet printer includes: a controlling unit, an inkjet head unit, and a nozzle compensation unit.

Abstract: A method of capping printheads positioned along a curved media path having an apex. The method includes the steps of: providing a first printhead upstream of the apex and a corresponding first capper downstream of the first printhead; providing a second printhead downstream of the apex and a corresponding second capper upstream of the second printhead; moving the first capper towards the first printhead and capping the first printhead; and moving the second capper towards the second printhead and capping the second printhead. The first and second cappers are moved in opposite directions away from the apex for capping the first and second printheads.