Patents Examined by Larry D Riggs, II
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Patent number: 10444248Abstract: The present invention provides a method of stratifying a patient suffering from CKD into one of stages 1-3 of CKD, comprising determining the level of the biomarkers FABP1, ?-GT, AST, creatinine and cystatin C in a sample obtained from the patient and comparing the level of FABP1 in the sample to a control value and the levels of ?-GT, AST, creatinine and cystatin C in the sample to a range of control values for each biomarker, wherein an increased level of FABP1 compared to the control value and levels of ?-GT, AST, creatinine and cystatin C within the range of control values for each biomarker indicate that the patient suffers from stage 1 CKD or wherein an increased level of FABP1 compared to the control value, levels of ?-GT and AST within the range of control values for each biomarker, and increased levels of creatinine and cystatin C compared to an upper threshold of the control range for these biomarkers indicate that the patient suffers from stage 2 or stage 3 CKD.Type: GrantFiled: August 12, 2013Date of Patent: October 15, 2019Assignee: Randox Laboratories Ltd.Inventors: Ivan McConnell, Stephen Peter Fitzgerald, John Lamont, Claran Richardson
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Patent number: 10434255Abstract: A system and method for patient-adaptive hemodynamic management is described. One embodiment includes a system for hemodynamic management including transfusion, volume resuscitation with intravenous fluids, and medications, utilizing monitored hemodynamic parameters including the described dynamic predictors of fluid responsiveness, and including an intelligent algorithm capable of adaptation of the function of the device to specific patients.Type: GrantFiled: November 20, 2013Date of Patent: October 8, 2019Assignee: The Regents of the University of CaliforniaInventors: Joseph B. Rinehart, Maxime Cannesson
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Patent number: 10437963Abstract: An apparatus and method for generating a prescription form is disclosed. The method includes displaying a first menu containing a plurality of therapy menu items. The method also includes displaying a second menu containing at least one qualifier menu item. The method further includes displaying a third menu containing at least one drug menu item. The method includes, upon selection of a therapy menu item, a qualifier menu item, and a drug menu item, selecting a protocol including one or more patient specific pump parameters corresponding to the therapy menu item, the qualifier menu item, and the drug menu item. The method also includes displaying a prescription form including at least one of the one or more patient specific pump parameters.Type: GrantFiled: February 19, 2015Date of Patent: October 8, 2019Assignee: Smiths Medical ASD, Inc.Inventor: Michael L. Blomquist
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Patent number: 10438700Abstract: Time-varying hyperglycemic stresses are derived from actual ICU patients and applied to non-critically ill virtual patients, using any model of normal glucose-insulin physiology that fulfills certain requirements, in order to model and simulate stress hyperglycemia. Other aspects provide: 1) a methodology to perform sensitivity analyses of the parameters of ICU insulin infusion therapy protocols and to improve the protocols; and 2) a training system for clinicians about the course and management of stress hyperglycemia in the ICU or other facility.Type: GrantFiled: August 5, 2013Date of Patent: October 8, 2019Assignee: University of Virginia Patent FoundationInventors: Edward A. Ortiz, Stephen D. Patek, Marc D. Breton, Leon S. Farhi, Boris P. Kovatchev
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Patent number: 10430613Abstract: A blood glucose measuring device and method for transmitting measured bG values to an external device such as a computer with improved data integrity for greater reliability is disclosed. The measuring device comprises a measuring means for determining measured blood glucose values, a measured value memory in which the measured blood glucose values are stored, a data interface that is configured for a data exchange with an external data reading apparatus, and a data file system which comprises a data reading application which can be accessed by the external data reading apparatus in order to read the stored measured blood glucose values, wherein the data system file further comprises a test application that is configured to execute an integrity test for the data reading application by forming a current digital signature for the data reading application and comparing this with a digital test signature provided in the data file system.Type: GrantFiled: September 3, 2013Date of Patent: October 1, 2019Assignee: Roche Diabetes Care, Inc.Inventors: Karl Werner, Ulrich Porsch, Stefan Riebel
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Patent number: 10428370Abstract: Disclosed herein are methods of extracting genetic material from a diverse population of one or more types of microbes in a sample. Microbes can be prokaryotes or eukaryotes and may include bacteria, archaea, fungi, protozoa, helminths, parasites, viruses, phages, and others. Extraction may be from a single sample and subsequent identification may be through a molecular method such as qPCR, PCR, RFLP, SSCP, allele specific PCR, targeted sequencing, pull down sequencing, whole shotgun sequencing, or other methods.Type: GrantFiled: November 28, 2017Date of Patent: October 1, 2019Assignee: Sun Genomics, Inc.Inventor: Suneer Jain
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Patent number: 10431342Abstract: A method, system and related computer program product for tracking the probability of hypoglycemia from routine self-monitoring of blood glucose (SMBG) data in patients with diabetes. A specific bivariate probability distribution of low BG events based jointly on the Low BG Index (LBGI) and the Average Daily Risk Range (ADRR) is used to predict hypoglycemia probability of occurrence from inputted SMBG data. The SMBG data is retrieved from a series of SMBG data of a patient available from the patient's glucose meter and allows tracking of the probability for future hypoglycemia over a predetermined duration, e.g., a 24 or 48 hour period. The tracking includes presentation of visual and/or numerical output, as we construction of hypoglycemia risk trajectories that would enable warning messages for crossing of predefined thresholds, such as 50% likelihood for upcoming hypoglycemia below 50 mg/dl.Type: GrantFiled: September 2, 2010Date of Patent: October 1, 2019Assignee: University of Virginia Patent FoundationInventors: Boris P. Kovatchev, Marc D. Breton
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Patent number: 10431340Abstract: The present invention provides for a computer system that includes at least one server having software stored on a non-transient computer readable medium; where, upon execution of the software, the at least one server is at least configured to: i) receiving, in real-time, an input from a user; ii) receiving, in real-time, physiological data representative of a physiological measurement of physiological characteristic of the user; iii) comparing, in real-time, the physiological measurement of the user to a pre-determined physiological value associated with the physiological characteristic retrieved from a database; iv) based on the comparing, determining, in real-time, that a difference between the physiological measurement of the user and the pre-determined physiological value is higher or smaller than the predetermined threshold value, and then: v) generating, in real-time, at least one alert; vi) transmitting, in real-time, the at least one alert.Type: GrantFiled: February 27, 2015Date of Patent: October 1, 2019Assignee: Eco-FusionInventor: Oren Fuerst
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Patent number: 10407474Abstract: Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to more hydrophilic residues (e.g., charged amino acids). Any number of residues on the surface may be changed to create a variant that is more soluble, resistant to aggregation, has a greater ability to re-fold, and/or is more stable under a variety of conditions. The invention also provides GFP, streptavidin, and GST variants with an increased theoretical net charge created by the inventive technology. Kits are also provided for carrying out such modifications on any protein of interest.Type: GrantFiled: September 2, 2016Date of Patent: September 10, 2019Assignee: President and Fellows of Harvard CollegeInventors: David R. Liu, Kevin John Phillips, Michael S. Lawrence
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Patent number: 10408846Abstract: The present technology relates generally to determining a risk of recurrence of disease in a cancer patient. In particular, this approach to determining a risk of recurrence involves utilizing standardized quantitative assessments of the level of biomarker expression selected from estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 (Ki67) in a patient's tumor to determine the risk of recurrence, thereby allowing a caretaker to determine the best course of treatment for the patient.Type: GrantFiled: March 15, 2013Date of Patent: September 10, 2019Assignee: Novartis AGInventors: Mark D. Gustavson, Jason Christiansen
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Patent number: 10405787Abstract: A method, data processing unit, and system for monitoring excrement data for seeking a pattern for a monitoring period, wherein said excrement data is associated with at least one absorbent article and a person wearing said at least one absorbent article is disclosed. The method includes acquiring excrement data including excrement data for at least two different time periods, each substantially corresponding to the monitoring period for which a pattern of events is sought, wherein said excrement data includes information of excrement into an absorbent article in form of excrement events, and wherein each excrement event has an associated time mark or associated information from which an associated time mark may be derived; and smoothing the time mark of each excrement event.Type: GrantFiled: December 20, 2013Date of Patent: September 10, 2019Assignee: ESSITY HYGIENE AND HEALTH AKTIEBOLAGInventors: Carolyn Berland, Mattias Bosaeus, Pär Johannesson
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Patent number: 10401337Abstract: A method of quantifying analytes from mass spectral data, comprising: obtaining a first set of mass spectral data from a first set of analytes eluted from a chromatography column; obtaining a second set of mass spectral data from a second set of analytes eluted from a chromatography column; determining apparent abundances of analytes in each data set; selecting a target analyte and determining localized neighboring analytes by their locality to the target analyte with respect to retention time; determining a locally corrected abundance of the target analyte based on differences between the first and second data sets in the apparent abundance of the localized neighboring analytes; and quantifying the target analyte based on its corrected abundance. A majority of the neighboring analytes are typically substantially unchanged in actual abundance between the first and second data sets and can be used for aligning the abundances between the data sets.Type: GrantFiled: March 28, 2013Date of Patent: September 3, 2019Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Roman Zubarev, Yaroslav Lyutvinskiy
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Patent number: 10400284Abstract: The present invention relates to a method for predicting whether a patient with a cancer is likely to respond to an epidermal growth factor receptor (EGFR) inhibitor, which method comprises determining the expression level hsa-miR-31-3p miRNA in a sample of said patient. The invention also relates to therapeutic uses of an EGFR inhibitor in a patient predicted to respond to said EGFR inhibitor.Type: GrantFiled: November 23, 2012Date of Patent: September 3, 2019Assignees: INTEGRAGEN, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, UNIVERSITE PARIS DESCARTESInventors: Thomas Rio Frio, Pierre Laurent-Puig, Sandrine Imbeaud
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Patent number: 10403397Abstract: A method of administering insulin includes receiving subcutaneous information for a patient at a computing device and executing a subcutaneous outpatient program for determining recommended insulin dosages. The subcutaneous outpatient program includes obtaining blood glucose data of the patient from a glucometer in communication with the computing device, aggregating blood glucose measurements to determine a representative aggregate blood glucose measurement associated with at least one scheduled blood glucose time interval, and determining a next recommended insulin dosage for the patient based on the representative aggregate blood glucose measurement and the subcutaneous information. The method also includes transmitting the next recommended insulin dosage to a portable device associated with the patient. The portable device displays the next recommended insulin dosage.Type: GrantFiled: September 6, 2018Date of Patent: September 3, 2019Assignee: Aseko, Inc.Inventors: Robert C. Booth, Harry Hebblewhite
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Patent number: 10398379Abstract: Systems, devices and methods for managing a physiological condition are configured to store predetermined output segments of content, analyze physiological data and other user information, and generate user-friendly information that provides an interpretation of the data (e.g., identifies selected data points, or determines pattern of physiological data over selected period(s)). An output segment management system with rules engine and method combines selected output segments to generate a presentation or message (e.g., with text, graphical, multimedia, video and/or audio information). The resulting presentation or message provides user information such as an explanation of selected data with selected user information incorporated therein, and optional recommendations (e.g., suggested user actions based on a designated protocol such as a clinical protocol).Type: GrantFiled: December 14, 2012Date of Patent: September 3, 2019Assignee: Becton, Dickinson and CompanyInventors: James Petisce, Ellen DiResta, Deborah Burns, David Mason, Sami Kanderian
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Patent number: 10383556Abstract: A medical diagnostic device includes a wirelessly transmitted time data receiver and processor. Associated devices, methods and functionality are also described.Type: GrantFiled: June 8, 2009Date of Patent: August 20, 2019Assignee: Intuity Medical, Inc.Inventors: Kelley J. Lipman, Michael F. Tomasco, Daniel N. Brncic, David K. Hohl, Paul D. Reynolds, Raul Escutia
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Patent number: 10385396Abstract: Provided herein are methods and computer-readable storage media related to cell-free DNA and uses thereof to determine risk of a condition, such as transplant rejection or cancer, in a subject.Type: GrantFiled: April 19, 2013Date of Patent: August 20, 2019Assignee: The Medical College of Wisconsin, Inc.Inventors: Aoy Tomita Mitchell, Michael Mitchell
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Patent number: 10383580Abstract: A system and method to provide guidance for diabetes therapy includes determining glycemic risks based on an analysis of glucose data. The analysis includes visualization of a glucose median, the variability of glucose in a patient, and the risk of hypoglycemia. An Advanced Daily Patterns report includes a visualization of an ambulatory glucose profile and a glucose control measure. The glucose control measure provides a highly visible and understandable display of the glucose condition of a patient visually expressed in the categories of low glucose, median glucose, and glucose variability.Type: GrantFiled: December 31, 2013Date of Patent: August 20, 2019Assignee: ABBOTT DIABETES CARE INC.Inventors: Timothy C. Dunn, Kenneth J. Doniger, Glenn Berman, Gary A. Hayter, Erwin S. Budiman, Daniel M. Bernstein, Nathan Crouther
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Patent number: 10381106Abstract: A high performance, low-cost, gapped read alignment algorithm is disclosed that produces high quality alignments of a complete human genome in a few minutes. Additionally, the algorithm is more than an order of magnitude faster than previous approaches using a low-cost workstation. The results are obtained via careful algorithm engineering of the seeding based approach. The use of non-hashed seeds in combination with techniques from search engine ranking achieves fast cache-efficient processing. The algorithm can also be efficiently parallelized. Integration into an in-memory database infrastructure (IMDB) leads to low overhead for data management and further analysis.Type: GrantFiled: January 27, 2014Date of Patent: August 13, 2019Assignee: Hasso-Plattner-Institut Fuer Softwaresystemtechnik GmbHInventors: Hasso Plattner, Matthieu-Patrick Schapranow, Emanuel Ziegler
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Patent number: 10378052Abstract: A whole-genome sequencing method, including: 1) extracting a whole-genome DNA and constructing a BAC library; 2) constructing mixing pools; 3) extracting DNA of the mixing pools; 4) performing pair-end sequencing for the DNA from the mixing pools; 5) scanning sequences of each mixing pool to obtain a feature sequence set and a k-mer set of each mixing pool; 6) analyzing a corresponding feature sequence set and a corresponding k-mer set of each clone; 7) constructing clone contigs; 8) dividing the k-mer sets of the clones into small k-mer sets and positioning the small k-mer sets; 9) assembling the NGS sequences to yield sequence contigs; 10) positioning the sequence contigs, connecting the sequence contigs and determining directions thereof; and 11) determining relative positions and directions of the clone contigs, and connecting the sequences of clone contigs as whole stripe of chromosome sequences.Type: GrantFiled: January 8, 2016Date of Patent: August 13, 2019Assignee: HUAZHONG AGRICULTURAL UNIVERSITYInventors: Meizhong Luo, Yonglong Pan