Patents Examined by Larry Helms
  • Antiproliferative SgK reagents and methods
    Patent number: 7087392
    Abstract: The invention provides methods and compositions relating to activated Sgk and the association of activated Sgk activity with proliferating cells, including methods for inhibiting the growth of an undesirably proliferating cell by contacting the cell with a specific inhibitor of activated Sgk whereby the amount of activated Sgk activity in the cell is reduced. Specific inhibitors are disclosed, including dominant negative mutants of activated Sgk, an Sgk mutant or fragment thereof comprising an unphosphorylatable residue corresponding to Thr256 of native Sgk, and an active Sgk-specific antibody or antibody fragment, especially intrabody, etc. A wide variety of methods may be used to contact the target cell with the inhibitor, especially introducing into the cell a polynucleotide encoding the inhibitor under conditions whereby the inhibitor is expressed in the cell.
    Type: Grant
    Filed: July 4, 2002
    Date of Patent: August 8, 2006
    Assignee: The Regents of the University of California
    Inventors: Gary L. Firestone, Anita C. Maiyar, Patricia Buse, Lisa M. Bell, Meredith L. L. Leong
  • Human tumor-associated gene
    Patent number: 6673914
    Abstract: The present invention describes a novel tumor marker antigen encoded by a gene designated as HOJ-1 (SEQ ID NO:1). In specific embodiment, the nucleic acid sequences disclosed herein are for used in the diagnosis and prognosis of cancer. Also provided are related protein and antibody compositions and various methods of use thereof, including methods for cancer diagnosis and treatment.
    Type: Grant
    Filed: January 21, 1999
    Date of Patent: January 6, 2004
    Assignee: John Wayne Cancer Institute
    Inventor: David S. B. Hoon
  • Antibody variants
    Patent number: 6632926
    Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
    Type: Grant
    Filed: November 16, 1999
    Date of Patent: October 14, 2003
    Assignee: Genentech, Inc.
    Inventors: Yvonne M. Chen, Henry B. Lowman, Yves Muller
  • Non-invasive method to detect prostate cancer
    Patent number: 6383759
    Abstract: The present invention is directed to methods of detecting prostate cancer in a sample of a body fluid with prostate cell marker-specific and epithelial cell marker-specific antibodies as well as to kits comprising such antibodies for use in the detection of prostate cancer. The present invention is also directed to methods of detecting prostate cancer in a sample of a body fluid with prostate cell marker-specific and tumor associated marker-specific antibodies as well as to kits comprising such antibodies for use in the detection of prostate cancer.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: May 7, 2002
    Assignee: Gerald P. Murphy Cancer Foundation
    Inventors: Gerald P. Murphy, Alton L. Boynton, Eric H. Holmes, Robert J. Barren, III