Abstract: A handheld cryoanesthesia or analgesia device for cooling a target area on cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone having an elongated body and a thermoelectric cooling system disposed within the elongated body. The thermoelectric cooling system is configured to physically contact and thermally couple the target area of the cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone to induce cryoanesthesia or analgesia. The thermoelectric cooling system includes a thermally-conductive cold tip, a thermally-conductive cooling power concentrator thermally coupled to the cold tip, at least one Peltier unit module thermally coupled to the cooling power concentrator, a heatsink thermally coupled to at least one Peltier unit module, a power source, at least one thermal sensor, and a controller operably outputting a control signal to the Peltier unit module to maintain a predetermined temperature.

Abstract: Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

Abstract: Embodiments of the present invention are related to a multichambered syringe including a main body. The main body may include a body first end, a body second end, and a body housing extending from the body first end to the body second end. Within the body housing may be at least one separating member, a plurality of chambers, and a puncture device. The puncture device may be structured to breach the at least one separating member. The puncture device and the at least one separating member may be structured to form a plurality of guided tunnels when the puncture device and the at least one separating member are engaged.

Abstract: A catheter assembly includes: a catheter; a catheter hub; an inner needle; a needle hub; and a deflection suppressing mechanism suppressing deflection of the inner needle. The deflection suppressing mechanism includes an upper deflection suppressing portion positioned on an upper side of the inner needle and a lower deflection suppressing portion positioned on a lower side of the inner needle. At least one of the upper deflection suppressing portion and the lower deflection suppressing portion is movable with respect to the needle hub.

Abstract: Disclosed is an auto-injection apparatus for receiving a syringe, including: an outer casing enclosing a drive assembly and a syringe carrier configured to hold a barrel of the syringe, the syringe carrier being forward of the drive assembly and having stowed and delivery positions; an interlock extending between the syringe carrier and a syringe carrier housing at least partially surrounding the syringe carrier, the interlock preventing forward motion of the syringe carrier under the influence of an insertion actuator whilst in the stowed position. The drive assembly includes the insertion actuator for inserting a needle of the syringe into an injection site and a delivery actuator for driving a plunger into a barrel of the syringe which contains a substance for injection. The syringe carrier includes an interlock release mechanism which is configured to release the interlock such that the insertion actuator drives the syringe carrier forward.

Abstract: The present disclosure relates to a disposable injection needle, including: a needle mount, having a tube needle; a first sleeve, one end of which is suitable for connecting to the needle mount to form receiving space, and the other end of which is provided with a first opening; a second sleeve, one end of which is located inside the receiving space, and the other end of which having a second opening extends out from the first opening, wherein the second sleeve is axially slideable; an elastic element adapted to allow the second sleeve to move axially toward outside the receiving space, wherein: the second sleeve is provided with a sleeve guiding portion, and the needle mount is provided with a guiding engagement portion, the sleeve guiding portion engages with the guiding engagement portion to guide the circumferential rotation of the second sleeve based on axial movement of the second sleeve toward inside of the receiving space; the first sleeve is provided with a blocking member and the second sleeve is pr

Abstract: A full-face mask assembly includes a frame and a cushion provided to the frame. The cushion is adapted to form a seal around the patient's nose and mouth. A flexible lip is provided to an interior wall of the cushion. The flexible lip is adapted to engage the frame to provide a seal in use.

Abstract: A balloon sheath and associated methods are provided. An alternative embodiment comprising a sheath having a flaring end and associated methods are also provided.

Abstract: A drug dispensing system with replaceable cartridges wherein the system indicates whether the cartridge is suitable for use.

Abstract: A syringe provided with a body, a piston capable of sliding in the body, and an injection device comprising a needle oriented along a longitudinal axis and a casing removably secured to the body and carrying said needle. The casing comprising a plurality of flexible tabs, each provided with a stop. The piston comprising a docking system having a housing comprising a flange configured to hold the stops of the flexible tabs in the housing in an insertion position in which the tabs are inserted into the housing, the plurality of tabs in opposing areas around the longitudinal axis. The flange comprising bearing areas configured to be in contact with corresponding tabs in the insertion position. The tabs are configured to exert an elastic pressure on corresponding bearing areas in the insertion position, and the bearing areas are dissymmetrical relative to the longitudinal axis.

Abstract: A dispenser includes a container with an endwall and a cap covering the endwall. The cap has an aperture and a first film covering the aperture. A hood over the cap has a barrel defining a bore which is coaxially aligned with the aperture, a second film sealing the bore, and a gasket compressed behind the second film. A spike is carried for movement in the barrel between retracted and advanced positions. The dispenser has first and second conditions. In the first condition, the first and second films are against each other and seal the aperture and barrel, and in the second condition, the first and second films are away, unsealing the aperture and the barrel. When the dispenser is in the second condition and the spike moves from the retracted position to the advanced position, the spike pierces the endwall.

Abstract: The present invention relates to a handheld mechanical injection device by which set doses of a liquid medicament can be injected from a medical reservoir. The medicament is expelled through an injection needle by release of a power reservoir in the device, the power reservoir being fully or partially released by actuation of a user operable release member being positioned at or near an upper end of the injection device, the upper end being that end of the injection device which is opposite the injection needle.

Abstract: A neurovascular catheter having an angled distal tip has an elongate flexible tubular body with a proximal end, a distal end and a side wall defining a central lumen. The side wall has a helical coil. A tubular jacket surrounds the helical coil, and extending distally beyond the helical coil distal end to terminate in a catheter distal face. A tubular radiopaque marker is embedded in the tubular jacket in between the distal end of the coil and the distal face. The distal face resides on a plane which crosses a longitudinal axis of the tubular body at an angle within the range of from about 35 degrees to about 55 degrees. The marker has a proximal face that is approximately perpendicular to the longitudinal axis and a distal face that resides on a plane which crosses the longitudinal axis at an angle within the range of from about 35 degrees to about 55 degrees.

Abstract: An insulin delivery device (10) includes a cannula (40) for delivering insulin to a patient at an infusion site, a pump assembly (30), and a valve (36) for controlling the flow of insulin. A removable leak detector unit (28) is coupled to the delivery device for sensing and detecting leakage of insulin at the infusion site. The leak detector unit (28) has electrodes (56) positioned for contacting the insulin leaking from the infusion site, a sensing electrical circuit (54) and a power source (58) for operating the leak detector unit. The removable leak detector unit (28) has an electrical contact (62) for mating with an electrical contact (64) of the delivery device for electrically and operatively connecting the leak detector unit (28) to the delivery device. The leak detector unit (28) sends a signal to the pump assembly (30) and/or valve (36) to stop the flow of insulin when leakage is detected at the infusion site.

Abstract: A medicament delivery device and method of use thereof. The device includes a sensor module and an injector module. The injector module is adapted to (i) be coupled to the sensor module during injection of a cannula and a needle into subcutaneous tissue and during delivery of the medicament and (ii) be removed from the sensor module after the delivery of the medicament.

Abstract: A catheter assembly for regulation or transfer of fluids to and from a patient. The catheter assembly may include a catheter and a valve assembly. The valve assembly may include a diaphragm having two unidirectional slit valves that open in different directions, a first unidirectional slit valve opening distally in response to an infusion-induced pressure and a second unidirectional slit valve opening proximally in response to an aspiration-induced pressure.

Abstract: A needle cannula for an injection device, extends along a central axis and comprises: a) a skin piercing distal end (133b), b) a proximal end (133a) configured for penetrating a seal structure (102b) of a medicament container (102), and c) a sidewall extending between the skin piercing distal end (133b) and the proximal end (133a), wherein the proximal end (133a) is defined by an angled surface (134) pointing proximally, the angled surface (134) defining a leading portion (134.1) and a heel portion (134.2), and wherein the angled surface (134) comprises a surface portion (134a, 134b) at the heel portion (134.2) forming an angle (?1) between 50 to 75 degrees with respect to the central axis, and further comprises a surface portion (134c) at the leading portion (134.1) forming an angle (?2) between 60 to 85 degrees with respect to the central axis. An injection needle assembly for an injection device and an injection device comprising such assembly are further described.

Abstract: Gastric and intestinal feeding tube devices and methods can be enhanced to provide better patient outcomes. For example, this document provides gastric and intestinal feeding tube devices that include an external bumper with pressure sensors and pressure indicators that facilitate usage of the feeding tube devices within an appropriate range of skin surface pressure. This document also provides external bumpers with deflectable elements that facilitate the application of a controlled amount of force between the external bumpers and the skin surface.

Abstract: Embodiments are directed to portable infusion devices, systems, and methods of using the same for dispensing materials. In some cases, the devices, systems and methods may be used for infusing a material such as medicament, e.g., insulin, into a body in need thereof.

Abstract: One embodiment is directed to a safety syringe system, comprising: an off-the-shelf syringe assembly comprising a syringe body and a plunger tip; a needle assembly removably coupleable to the distal end of the syringe body such that medicinal fluid may be transferred through a retractable needle coupled to a needle housing comprising the needle assembly upon insertion of the plunger tip relative to the syringe body; and a plunger control assembly coupled to the plunger tip and configured to facilitate manual insertion of the plunger tip relative to the syringe body; wherein upon insertion of the plunger tip to a final insertion state and release of an associated manual insertion load, the plunger tip may be proximally withdrawn, pulling the retractable needle proximally relative to the needle housing to a safe locked and retracted state wherein it is no longer exposed for injection.