Patents Examined by Laura M Mitchell
  • Transgenic fish germline expression driven by liver fatty acid binding (L-FABP) gene promoter and applications thereof
    Patent number: 7411060
    Abstract: The present invention relates to expression control sequences of a vertebrate liver fatty acid binding protein (L-FABP) gene that, when operably linked to a reporter (e.g., a heterologous reporter, such as the green fluorescent protein (GFP)), directly express the reporter in a fashion that mimics the liver-specific development of the L-FABP gene in the vertebrate.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: August 12, 2008
    Assignee: Academia Sinica
    Inventors: Jen-Leih Wu, Guor Mour Her
  • Dendritic cell line
    Patent number: 7341870
    Abstract: The invention relates to plasmacytoid dendritic human cell lines and methods for producing the cell lines. More specifically, the invention relates to the plasmacytoid dendritic human cell line called GEN2.2, which is deposited in the CNCM under number CNCM 1-2938 and the plasmacytoid dendritic human cell line called GEN3, which is deposited in the CNCM under number I-3110. The use of cells from the cell lines is also disclosed.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: March 11, 2008
    Assignee: Etablissement Francais du Sang
    Inventors: Joel Plumas, Laurence Chaperot-Dubonnet
  • Rationally designed and chemically synthesized promoter for genetic vaccine and gene therapy
    Patent number: 7312202
    Abstract: The present invention relates to chemically synthesized promoters that circumvent the disadvantages of the universal CMV promoter/enhancer elements. The promoter may be used in a variety of applications, particularly in genetic immunization. The chemically synthesized promoter overcomes the common problems of the CMV promoter element such as: low transgene expression levels, transient expression, and the large amount of plasmid DNA needed for intramuscular injection in subjects.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: December 25, 2007
    Assignee: Board of Regents, The University of Texas System
    Inventors: Stephen Johnston, Bao-Xi Qu
  • Processes for culturing E1-immortalized cells to increase product yields
    Patent number: 7291484
    Abstract: The invention provides processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, preferably PER.C6® (human embryonic retina) cells, to improve product yields from such cells. Feed strategies for such cells and cultures with very high cell densities are provided, resulting in high yields of products, such as recombinant antibodies.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: November 6, 2007
    Assignee: Crucell Holland B.V.
    Inventor: Christopher A. Yallop