Patents Examined by Lauren K Van Buren
  • Patent number: 10946046
    Abstract: A method for sterilising a platelet lysate in the liquid state comprising at least the endogenous growth factors TGF-beta 1, EGF, PDGF-AB, IGF-1, VEGF and bFGF. The method comprising freezing the liquid platelet lysate in order to obtain a frozen platelet lysate, and irradiating the frozen platelet lysate with ionising radiation in order to obtain a sterilised platelet lysate, the irradiation being adapted so as to preserve at least 80% of the concentration of at least one of the endogenous growth factors chosen from the group consisting of TGF-beta 1, EGF, PDGF-AB, IGF-1 and VEGF.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: March 16, 2021
    Assignee: Maco Pharma
    Inventors: Bruno Delorme, Sabrina Viau, Francis Goudaliez
  • Patent number: 10914657
    Abstract: The formulations, systems, and methods disclosed herein permit automated preparation of specimens (e.g., biological specimens) for examination. The disclosed formulations, systems, and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation phases for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining specimens.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: February 9, 2021
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: Daniel Lapen, Kerri Horton
  • Patent number: 10894086
    Abstract: The present invention relates to a functional hydrated hyaluronic acid and a method for producing 5th generation coated lactic acid bacteria having excellent intestinal mucoadhesive ability and a selective antagonism using the same and, more specifically, to a functional hydrated hyaluronic acid in which components fermented by lactic acid bacteria are captured in hyaluronic acid, which is a natural polymer substance, and a method for producing coated lactic acid bacteria using the same. The quadruply coated lactic acid bacteria coated using the functional hydrated hyaluronic acid according to the present invention is quadruply coated with a water-soluble polymer, a functional hydrated hyaluronic acid, a coating agent having porous particles, and a protein, thereby producing an excellent intestinal mucoadhesive ability, exhibiting an antibacterial action against deleterious bacteria in the intestines, and promoting growth of beneficial bacteria in the intestines.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: January 19, 2021
    Assignee: ILDONG PHARMACEUTICAL CO., LTD.
    Inventors: Seung-Hun Lee, Dae Jung Kang, Jae-Hoon Kang
  • Patent number: 10876096
    Abstract: Cell culture compositions containing LFM-A13 or a structurally related compound can enhance global hepatic function. For example, LFM-A13 is shown to enhance levels of a broad variety of drug metabolism enzymes, including CYP enzymes, and other hepatic enzymes. LFM-A13 is also shown to promote differentiation of stem cells into hepatocytes. LFM-A13 and structurally related compounds can be used in cell culture to enhance global drug metabolism of liver cells for enhanced in vitro study the effects of drug metabolism on other candidate drug compounds.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: December 29, 2020
    Assignee: Corning Incorporated
    Inventors: Ronald Allen Faris, Yulong Hong, Joydeep Lahiri, Jin Liu, Olivia Grace Weeks
  • Patent number: 10856566
    Abstract: Embodiments of the invention are related generally to compositions comprising Co-Q10, a source of omega-3 fatty acids, and vitamin D, and methods of making thereof. In particular, the invention relates to stable compositions comprising Co-Q10, krill oil, vitamin D, and an antioxidant suitable for use as dietary supplements, and methods of making thereof. The compositions may further comprise an emulsifier to impart stability to the compositions.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: December 8, 2020
    Assignee: RB HEALTH (US) LLC
    Inventors: Ed Derohanes, Kenneth Rayl, Michal Siwek, John Williams
  • Patent number: 10772333
    Abstract: A composition and methods of using the composition for the control of mollusks are provided, which include an effective amount of one or more isolated Phasmarhabditis nematodes, wherein at least one of the isolated nematodes is P. californica, P. papillosa or P. hermaphrodita, and wherein the P. hermaphrodita does not comprise Moraxella osloensis.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: September 15, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Irma Tandingan De Ley, Rory McDonnell, Timothy Paine
  • Patent number: 10772932
    Abstract: A medicament for use in treating cardiovascular and cerebrovascular diseases, the medicament includes a marine algal glycoprotein.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: September 15, 2020
    Assignee: SHANDONG ZHONGHAI PHARMACEUTICAL CO. LTD
    Inventors: Baozhen Xu, Qian Cheng, Long Cheng
  • Patent number: 10745723
    Abstract: The present invention relates to a method for increasing polyhydroxyalkanoates (PHAs) content of waste sludge, by taking the fermentation liquid fermented from waste sludge as a carbon source, and performing ADF domestication process, thereby quickly raising PHAs contentin the waste sludge, in accordance with the method of the present invention, the conventional complicated domestication steps is simplified and a higher content PHAs can be produced, additionally the added carbon source of the present invention is the VFA fermented by the waste sludge, so it's unnecessary to add extra material, therefore including more industrial utilization.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: August 18, 2020
    Assignee: National Chi Nan University
    Inventors: Yung-Pin Tsai, Meng-Shan Lu, Chih-Chi Yang, Hao Shiu, Jan-Wei Lin, Yu-Wei Liou
  • Patent number: 10677799
    Abstract: Ctsk is used as a marker to identify, track, and manipulate Ctsk positive cartilaginous stem cells for cartilage repair and regeneration in vitro and in vivo.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 9, 2020
    Assignee: Rhode Island Hospital
    Inventors: Wentian Yang, Nikhil Thakur
  • Patent number: 10668102
    Abstract: This application discloses alginate microencapsulation-mediated differentiation of embryonic stem cells and use of the stem cell differentiation method for the development of effective treatment of various diseases and disorders. The microencapsulation of embryonic stem (ES) cells results in decreased cell aggregation and enhanced neural lineage differentiation through incorporating the soluble inducer retinoic acid (RA) into the permeable microcapsule system. This differentiation process can be augmented by differentiation pathway regulators such as PPAR agonists.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: June 2, 2020
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Jean-Pierre Dolle, Rene S. Schloss, Martin L. Yarmush
  • Patent number: 10673087
    Abstract: A bio-energy power system comprising a selection process, an extraction process, and a transfer process. More specifically, a bio-energy power system that uses a selection process to create an energy enhanced organism. In some embodiments, the energy is extracted and consumed using an extraction process to create an energy rich homogenate from the energy enhanced organism and a transfer process to transfer the energy from the energy rich homogenate to the grid or to an energy storage device. In other embodiments, the energy enhanced organism is kept alive and the energy is extracted and consumed using a pure quartz water system for extraction and a transfer process to transfer the energy from the pure quartz water system to the grid or to an energy storage device.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: June 2, 2020
    Assignee: Kohane Technologies, LLC
    Inventor: Michael Kohane
  • Patent number: 10662408
    Abstract: This disclosure relates to methods for sorting sperm cells in a microfluidic chip. In particular, various steps are incorporated to align and orienting sperm in flow channels, as well as, to determining sperm orientation and measure relative DNA content for analysis and/or sorting.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 26, 2020
    Assignee: Inguran, LLC
    Inventors: Johnathan Charles Sharpe, Nemanya Sedoglavich, Blair Morad, Donald Francis Perrault, Jr.
  • Patent number: 10656056
    Abstract: The formulations, systems, and methods disclosed herein permit automated preparation of specimens (e.g., biological specimens) for examination. The disclosed formulations, systems, and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation phases for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining specimens.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: May 19, 2020
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: Daniel Lapen, Kerri Horton
  • Patent number: 10656058
    Abstract: The present invention relates to a material for aggregating blood cells, used in the preparation of a paraffin block for diagnosing circulating tumor cells (CTCs), and a method for preparing a paraffin block using the same, and more specifically, to a method for detecting CTCs present in the blood through blood sample collection in the preparation of a paraffin block from CTCs, which are present in a very small amount in the blood. The present invention is non-invasive and simple, and thus is very useful for the diagnosis of cancer recurrence and metastatic cancer and for prognosis prediction, and can be a remarkable breakthrough in cancer treatment through the analysis of the onset, metastasis and recurrence mechanisms of cancer.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: May 19, 2020
    Assignee: NATIONAL CANCER CENTER
    Inventors: Hee Jin Chang, Sun Young Kim, Ji Yeon Baek, Hyun Yang Yeo
  • Patent number: 10645962
    Abstract: The present disclosure relates to a Bacillus amyloliquefaciens CJ14-6 strain isolated from traditional meju, a preparation method for soybean koji using the same, and a soybean koji prepared by the preparation method. The preparation method for soybean koji includes: soaking soybeans in water or adding waster to soybeans and steaming the soaked soybeans; and inoculating a Bacillus amyloliquefaciens CJ14-6 strain into the steamed soybeans, fermenting the steamed soybeans, and drying the fermented soybeans to prepare a soybean koji.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: May 12, 2020
    Assignee: CJ Cheiljedang Corporation
    Inventors: Hye Jin Kim, Dong Joo Shin, Hye Won Shin, Eun Seok Jang, Dae Ik Kang, Byoung Seok Moon, Seon Mi Oh, Sun A Cho
  • Patent number: 10584312
    Abstract: The present invention relates to a method for isolating pluripotent/multipotent stem cells derived from umbilical cord blood, characterized by culturing mononuclear cells isolated from umbilical cord blood in a culture vessel containing fibronectin and then harvesting stem cells from the culture, the umbilical cord blood-derived pluripotent/multipotent stem cells isolated thereby; and a cell therapeutic agent containing the pluripotent/multipotent stem cells derived from umbilical cord blood or cells differentiated therefrom. The present invention also relates to a novel culture media for stem cells, a culture method for stem cells which is characterized by culturing and proliferating stem cells in the culture media, and a method for increasing sternness of stem cells which is characterized by a sphere culture or a three-dimensional culture of stem cells.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: March 10, 2020
    Assignee: SNU R&DB FOUNDATION
    Inventors: Kyung Sun Kang, Kyoung Hwan Roh
  • Patent number: 10584311
    Abstract: The present disclosure provides a method for aseptically culturing fruiting bodies of Antrodia cinnamomea, including: inoculating Antrodia cinnamomea strains in a sterilized agar medium, and performing a subculture to generate secondary mycelia and fruiting bodies of Antrodia cinnamomea.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: March 10, 2020
    Inventor: Shiu-Nan Chen
  • Patent number: 10576104
    Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: March 3, 2020
    Assignee: Osiris Therapeutics, Inc.
    Inventors: Samson Tom, Alla Danilkovitch, Dana Yoo, Timothy Jansen, Jin-Qiang Kuang, Jennifer Michelle Marconi
  • Patent number: 10576519
    Abstract: This present invention relates to compositions and methods of microbial enhanced oil recovery using Bacillus subtilis strains. The invention also relates to compositions and methods for performing oil degradation with Bacillus subtilis strains. The compositions and methods of the present invention are also used for enhanced commercial biosurfactant and enzyme production.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: March 3, 2020
    Assignee: LOCUS OIL IP COMPANY, LLC
    Inventors: Sean Farmer, Xiaozhou Zhang, Sharmistha Mazumder, Maja Milovanovic
  • Patent number: 10544391
    Abstract: This disclosure relates to methods for sorting sperm cells in a microfluidic chip. In particular, various steps are incorporated to align and orienting sperm in flow channels, as well as, to determining sperm orientation and measure relative DNA content for analysis and/or sorting.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 28, 2020
    Assignee: Inguran, LLC
    Inventors: Johnathan Charles Sharpe, Nemanya Sedoglavich, Blair Morad, Donald Francis Perrault, Jr.