Abstract: A surgical gas delivery device includes a filter cartridge interface and a computer controlled control unit configured to control the circulation of surgical gas during endoscopic surgery. The control unit can operate in a plurality of different modes of operation. A tube set for connecting the surgical gas delivery device to one or more end effectors includes a filter cartridge in fluid communication with the tube set. The filter cartridge is seated in the filter cartridge interface of the surgical gas delivery device to communicate surgical gas between the surgical gas delivery device and the one or more end effectors. The surgical gas delivery device includes a reader operatively connected to receive input from a data carrying element of the tube set. The data carrying element, reader, and control unit can launch a specific one of the modes of operation when the filter cartridge is inserted.

Abstract: A medical device includes an inflatable balloon defining an interior surface and an exterior surface, and a coating including a therapeutic agent disposed on the exterior surface of the inflatable balloon. The coating has a release transition temperature within a range from about 25° C. to about 50° C. When the temperature of the coating is below the release transition temperature, the coating retains at least a portion of the therapeutic agent on the exterior of the inflatable balloon. When the temperature of the coating is above the release transition temperature, the coating releases at least a portion of the therapeutic agent from the exterior of the inflatable balloon.

Abstract: A catheter shaft includes a first tube made of an extrudable copolymer that has reactive groups, and a second tube made of a polymeric material, which is welded to the first tube. A distal balloon is welded to the first tube.

Abstract: The present disclosure describes flow stagnation control components that allow improved flow control in systems including injection members, while also limiting the creation of regions of little to no flow in the vasculature, resulting in low flow zones or dead zones. The flow stagnation control components can be formed as an imposed minimum conductance component or a controlled flow partitioning system.

Abstract: A device and method for intravascular treatment of atherosclerotic plaque prior to balloon angioplasty which microperforates the plaque with small sharp spikes acting as serrations for forming cleavage lines or planes in the plaque. The spikes may also be used to transport medication into the plaque. The plaque preparation treatment enables subsequent angioplasty to be performed at low balloon pressures of about 4 atmospheres or less, reduces dissections, and avoids injury to the arterial wall. The subsequent angioplasty may be performed with a drug-eluting balloon (DEB) or drug-coated balloon (DCB). The pre-angioplasty perforation procedure enables more drug to be absorbed during DEB or DCB angioplasty, and makes the need for a stent less likely. Alternatively, any local incidence of plaque dissection after balloon angioplasty may be treated by applying a thin, ring-shaped tack at the dissection site only, rather than applying a stent over the overall plaque site.

Abstract: The present invention relates to a syringe, and more particularly, to an apparatus obtained by improving an conventional syringe formed with an injection flow passage including an injection needle, so as to share a portion of the injection flow passage except the injection needle or to form a suction flow passage completely independent of the injection flow passage, thereby further smoothing suction of a liquid medicine. The syringe is configured such that the separate suction flow passage bypassing the injection needle is formed in an conventional syringe to more smoothly perform the suction of the liquid medicine, thereby maximizing user's convenience and marketability of the product.

Abstract: A method includes providing microvalve device having inner and outer catheters, and a filter valve attached to the distal end of the inner and outer catheters. Longitudinal displacement of the inner catheter relative to the outer catheter moves the filter valve from a non-deployed configuration to a deployed configuration. With the inner catheter longitudinally advanced a first amount relative to the outer catheter, the filter valve is in a reduced first diameter for advancement of a guidewire to a target location. Once the filter valve reaches the target location, the inner catheter is moved relative to the outer catheter such that the filter valve assumes a larger second diameter. A therapeutic agent is infused through the inner catheter and beyond the filter valve.

Abstract: A safety catheter needle having a cannula removably inserted in a catheter and associated with a cannula holder is provided. The cannula has a proximal extremity attached to the cannula holder and a distal extremity close to a deformed part, with provision for a protection device associated with the catheter holder movably containing the cannula and moving within the catheter holder when the cannula is drawn out from the catheter. The protection device has a principal body containing a moving body rotating about an axis (M) at right angles to a longitudinal axis (W) of the cannula and capable of interacting with a fixed part of the catheter holder—while the cannula is being drawn out, bringing about rotation of the rotating moving body within the principal body and immobilizing the distal extremity of the cannula within the former.

Abstract: An infusion device system includes a base (12) for removably coupling to a delivery device, a needle hub (22) supporting an insertion needle (20) and a catheter (18) for delivering a substance to a patient. The infusion device includes a needle shield (24) for covering the insertion needle (20) after inserting the catheter (18) into the patient. The needle hub (22) includes a least one leg (70) extending from the needle shield (24) to stabilize the needle shield (24) and needle hub (12) relative to the base. In one embodiment, the legs (70) can include a latching tab (74) to couple to the needle hub (22) to resist separation of the needle hub from the base (12) until the legs are deflected outward to release the needle hub (22).

Abstract: An embolization microcatheter having an elongated microcatheter body configured for passing therein a suspension of particles suspended in a suspension fluid; and a microcatheter head connected to a distal end of said microcatheter body and comprising a proximal head section and a distal head section, wherein the proximal head section includes a proximal wall forming a proximal section lumen, the proximal wall having a plurality of through-holes, wherein the distal head section includes a distal wall forming a distal section lumen, and a suspension delivery opening at a distal end of the distal end section; wherein the distal section is devoid of through-holes, and wherein each of the plurality of through-holes are shaped and/or sized to allow passage therethrough of the suspension fluid while blocking passage of the particles suspended therein.

Abstract: Embodiments of the invention include devices, compositions and methods for the controlled release of therapeutic substances, such as drugs. Control over the rate of release of the therapeutic substances from the devices is achieved by the use of nanoporous membranes in which the pore size is matched to the molecular diameter of the therapeutic substances. Some embodiments of the invention achieve zero-order release by the use of membranes with a pore diameter that is more than five times the Stokes' diameter of the therapeutic substance released.

Abstract: Methods for limiting dissipation of neurotoxins and dermal fillers from an injection site are disclosed, which includes applying a repellant electric field to the skin around the injection site to limit dissipation of an injected neurotoxin or dermal filler.

Abstract: An autoinjector has a main body (10, 12) containing a syringe (13) or cartridge with a needle at its front end for being moved forwardly in the body to extend the needle from the body for an injection, the body housing in a forward region a shroud (24) having a forward portion of generally tubular form (32), the shroud being moveable longitudinally between a rearward retracted position and a forward extended position, the autoinjector further including a spring arrangement for biasing the shroud forwardly, the spring arrangement (44) including two springs disposed alongside and spaced from the longitudinal axis.

Abstract: Fluid supply systems and methods for therapeutic fluid delivery systems, including those used for negative pressure wound therapy (NPWT) systems and methods.

Abstract: Controlled delivery of embolic beads into a subject's artery is achieved using a pump configured to draw fluid into a chamber and eject fluid from the chamber, one or more valves that control fluid-flow paths between three ports and the chamber of the pump, a valve actuator that places the one or more valves into various operating states, and a controller that controls the operation of the pump and the one or more valves in a controlled sequence. The various operating states interconnect one of the ports with a common port in fluid communication with the pump to achieve the controlled delivery of embolic beads.

Abstract: Needle assemblies are disclosed having a multi-purpose protective cap. The needle assemblies can embody a catheter assembly having a catheter hub and a catheter tube or a hypodermic needle mounted on a needle hub. The multi-purpose cap includes a first section covering the needle and a second section having a base portion for covering a hub, such as a needle hub or a catheter hub. The first section and the second section are separable from one another along a detachment line and the second section is re-useable as a securement device.

Abstract: An injector system for injecting fluid includes a syringe and an injector. The syringe includes a body and a plunger movably disposed within the body. The plunger has at least one flexible leg extending toward the rearward end of the body. The injector has a housing with a front plate, a drive member at least partially disposed within the housing and operable to engage the plunger, and a syringe release assembly operable to release the syringe. The syringe assembly includes a syringe release gear that forms an enclosure for receiving the syringe when the syringe is fully seated within the housing and a plunger release tube surrounding at least a portion of the drive member. The plunger release tube has a first end rotationally engaged with the syringe release gear. Rotation of the syringe release assembly releases the at least one flexible leg from the drive member.

Abstract: A pump cassette body for detecting air bubbles in a fluid pathway, comprises an upstanding flow director vane, a fitment integrally molded into the pump cassette body, wherein the fitment comprises a base integrally molded into the pump cassette body, an elastomeric member attached to the base, and a housing at least partially surrounding the elastomeric member, wherein the elastomeric member is co-molded to the housing.

Abstract: A catheter having a distal tip comprising two sections of different hardness, and a method of making the same, is herein disclosed. The first section of the two sections is distal to the second section of the two sections and the second section is comprised of a material that is harder than the material of the first section. Additionally, the distal tip is bonded to a catheter shaft and the material of the catheter shaft is harder than the material of the first and second sections. The material of the catheter shaft, first section, and second section can comprise polyether block amide, with each section and the catheter shaft having different properties.

Abstract: A multi-lumen sensing system (10) includes medical tubing (20) having a plurality of lumens (22A, 22B) and at least one secondary passageway (24) extending in an axial direction of the medical tubing, wherein the secondary passageway is between the plurality of lumens. The multi-lumen sensing system may include a sensing receptacle (30) defining a channel (32) in which a lengthwise portion of the medical tubing is received. A plurality of ultrasonic transmitting elements (40T, 42T) may be arranged within the secondary passageway of the medical tubing or as part of the sensing receptacle for transmitting respective ultrasonic signals across the lumens to a corresponding plurality of ultrasonic receiving elements (40R, 42R) of the sensing receptacle. Alternatively, the sensing receptacle may include a plurality of ultrasonic transmitting and receiving elements (40, 42, 44) transmitting respective signals across the lumens for return reflection at an interface of the secondary passageway.