Abstract: Stable, biocompatible cosmetic or dermatological oil-in-water emulsions (I), containing fatty acids and alcohols, glycerides, ethoxylated esters, non-polar lipids and consistency components, are new. Cosmetic or dermatological oil-in-water emulsion preparations (I) contain (by weight): (a) 0.1-5% 14-22 C fatty acid(s); (b) 0.2-10% fatty acid mono- and/or diglyceride(s); (c) 0.1-5% ethoxylated fatty acid ester(s); (d) 0.5-10% non-polar lipid(s); (e) 0.5-7.5% fatty alcohol(s); and (f) 0.5-7.5% lipophilic consistency source(s) having a melting point or drop point of at least 30 degrees C. The sum of the contents of (a)-(c) is at most 12% and the lipid phase optionally contains up to 40% (based on this phase) of polar lipids.

Abstract: A topical composition comprising: (a) conjugated linoleic acid and/or derivatives thereof; (b) a phenolic compound or mixtures thereof; and (c) a dermatologically acceptable vehicle; with the proviso that the phenolic compound is not a sunscreen. The product is particularly useful for treating wrinkles and soothing sensitive skin.

Abstract: An oily base, which has excellent stability, a low melting point and does not irritate the skin and an external composition which contains the oily base. The present invention is directed to an alpha-hydroxy fatty acid derivatives represented by the general formula (1): wherein R1 represents a straight-chain or branched alkyl group having 10 to 24 carbon atoms, R2 represents a straight-chain or branched alkyl group having 1 to 31 carbon atoms, and R3 represents a straight-chain or branched alkyl group having 11 to 31 carbon atoms, and an external composition contains at least one of the derivatives.

Abstract: A polyhedral borane cluster consists essentially of a fused polyhedron including an open decaborane cage fused to a closed dodecaborane cluster wherein borane atoms are not an integral part of the cluster vertices. The polyhedral borane cluster can be contained within a biomolecule for use as a neutron capture reagent. A method of synthesizing the polyhedral borane cluster includes the step of fusing an open decaborane cage to a closed dodecaborane cluster.

Abstract: &bgr;-Diketone/hydroxylated or carbonated activated cation inorganic/organic complexes are well suited for reducing skin irritation, notably that elicited by exposure to irritant active agents/species or to the external environment.

Abstract: 10-Hydroxy-2-decenoic acid and derivatives thereof are well suited for promoting desquamation and/or stimulating epidermal renewal and/or combating intrinsic/extrinsic aging of the skin of a candidate individual in need of such treatment, by administering thereto, for such period of time as required to elicit the desired response, an effective amount of at least one of said 10-hydroxy-2-decenoic acid or derivative thereof.

Abstract: A method for reducing coronary artery reactivity. A predetermined amount of natural progesterone is provided by a convenient and pleasant delivery system to the blood stream, sufficient to reduce the likelihood of coronary vasospasm and myocardial ischemia. The progesterone may be provided either by topical application to the epidermis of a cream in which the progesterone is dissolved or by patch technology, so as to provide continuous delivery and thereby maintain the level of progesterone in the blood stream at least about 1 nanogram per milliliter.

Abstract: The present invention provides therapeutic formulations for solutions of &Dgr;9-tetrahydrocannabinol (&Dgr;9 THC) to be delivered by metered dose inhalers. The formulations, which utilize non-CFC propellants, provide a stable aerosol-deliverable source of &Dgr;9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy; muscle spasticity; pain; anorexia associated with AIDS wasting syndrome; epilepsy; glaucoma; bronchial asthma; and mood disorders.

Abstract: An object of the present invention is to provide pharmaceutical compositions for inhibiting mesangial cell proliferation or mesangial matrix production without causing hypercalcemia. According to the present invention, therapeutic agents for glomerulosclerosis containing 1&agr;,3&bgr;-dihydroxy-20&agr;-(3-hydroxy-3-methylbutyloxy)-9,10-seco-5,7,10 (19)-pregnatriene as an active ingredient are provided.

Abstract: A formulation consisting of sodium bicarbonate, sodium carbonate and trisodium phosphate in aqueous solution is applied topically to treat an array of skin and tissue problems. The solution offers antibacterial, antiseptic, anti-fungal, and healing properties to skin scratches, cuts, sores, and fungal infected nails. In addition, the solution dries as a thin film to the applied surfaces, continuously providing antibacterial, anti-fungal and antiseptic activity beneath the protective film long after it has been applied.

Abstract: The present invention relates to oil-in-water mascara compositions comprising water-insoluble polymeric materials in the form of an aqueous emulsion, water-soluble, film-forming polymers and organophilic clays. Said compositions exhibit improved wear and are removable with soap and water.

Abstract: A composition in the form of a water-in-oil emulsion containing fibers, at least one silicone surfactant and-at least one wax. The composition obtained has very good stability and can in particular constitute a cosmetic composition. The invention also relates to the use of the said composition, in particular for caring for, treating, making up or cleansing the skin the lips, the eyelashes and/or the hair.

Abstract: The invention concerns the use of at least one protein extract of the Moringa genus plant seeds and a cosmetic and/or pharmaceutical composition containing at least one such extract. More particularly, the invention concerns the use of a protein extract of the Moringa genus plant seeds belonging to the Moringaceae family, as active principle, on its own or combined with at least another active principle, for preparing a cosmetic and/or pharmaceutical composition for topical use on the skin and/or skin appendages.

Abstract: A topical skin composition containing a dipeptide compound represented by, formula (1) or a salt of the dipeptide: wherein R1 represents a, hydrogen atom, an alkyl group, an alkanoyl group, or —CH(R6)COOR7 (wherein R6 represents a hydrogen atom or a lower alkyl group, and R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group); R2 represents a hydrogen atom or an alkyl group which may have a substituent; R3 represents a lower alkyl group or a phenyl group; R4 represents a hydrogen atom or a lower alkyl group, and may form a heterocyclic ring together with R5 and an adjacent nitrogen atom; R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, and may form the heterocyclic ring together with R4; X represents —COOR8 (wherein R8 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group) or —SO3H; and n is an integer of 0-4; and

Abstract: A novel method for the controlled delivery of therapeutic compounds to a region of a patient, using magnetic resonance focused therapeutic ultrasound, is disclosed.

Abstract: This invention describes galenical formulations that contain perfluoroalkyl-containing dye molecules and other perfluoroalkyl-containing substances. The new formulations are suitable as, i.a., contrast media for near-infrared diagnosis.

Abstract: The present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of a lipophilic drug, in association with a pharmaceutical carrier, said carrier comprising a lipophilic drug solubilizing effective amount of a propylene glycol monoester of C6-C18 fatty acid having at least 60% by weight monoester based on the total weight of the propylene glycol ester and a non-ionic surfactant.

Abstract: A formulation consisting of sodium bicarbonate, sodium carbonate and trisodium phosphate in aqueous solution is applied topically to treat an array of skin and tissue problems. The solution offers antibacterial, antiseptic, anti-fungal, and healing properties to skin scratches, cuts, sores, and fungus-infected nails. In addition, the solution dries as a thin film to the applied surfaces, continuously providing antibacterial, anti-fungal and antiseptic activity beneath the protective film long after it has been applied.

Abstract: A topical composition of a semi-solid consistency suitable is provided for transdermal application of prostaglandin E1. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an acid addition salt of an alkyl-2-(substituted amino)-alkanoate ester, of a (substituted amino)-alkanol alkanoate, or of a mixture thereof. The lipophilic compound may be an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.

Abstract: New macromolecular carriers for drugs and diagnostic agents are described that make use of the chemical attachment of new leashes to oligomeric backbone structures. The synthesis of these leashes and their facile creation, reaction and conjugation with chelators and ligands makes them ideal candidates for use in medicine, and especially diagnostics.