Patents Examined by Lawerence E Crane
  • 5? modified nucleosides and oligomeric compounds prepared therefrom
    Patent number: 9127033
    Abstract: The present invention provides 5? modified nucleosides and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified nucleosides having at least one 5?-substituent and an optional 2? substituent, oligomeric compounds comprising at least one of these modified nucleosides and methods of using the oligomeric compounds. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: September 8, 2015
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Thazha P. Prakash, Punit P. Seth, Eric E. Swayze
  • Chemical Compounds
    Patent number: 6455510
    Abstract: A compound of formula (I) which is an agonist at the adenosine A1 receptor wherein R2 represents C1-3alkyl, halogen or hydrogen; R3 represents a fluorinated straight or branched alkyl group of 1-6 carbon atoms and salts and solvates thereof, in particular, physiologically acceptable solvates and salts thereof. These compounds are agonists at the adenosine A1 receptor.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: September 24, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Richard Peter Charles, Brian Cox, Colin David Eldred, Andrew Michael Kenneth Pennell