Patents Examined by Layla Bland
  • Patent number: 9539231
    Abstract: A targeted approach toward the treatment of TN breast cancer by using AMPI-109 is disclosed. AMPI-109 is a compound with remarkable “cancer-specific” characteristics. In particular, AMPI-109 demonstrates a striking targeted capability to inhibit the proliferation of TN breast cancer cells and to induce apoptosis in TN breast cancer cells. The growth inhibitory effect of AMPI-109 is independent of VDR. AMPI-109 can also be coupled with other oncolytic agents in treating a patient with TN breast cancer.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: January 10, 2017
    Assignees: The Regents of the University of Colorado, a body corporate, Trustees of Boston University
    Inventors: Hamid Gari, Jim Lambert, Scott Lucia, Rahul Ray, Ann Thor
  • Patent number: 9393263
    Abstract: Provided are injectable, hyaluronic acid-based dermal filler compositions including conjugated vitamin C derivatives. The compositions provide for extended release of active vitamin C into tissue, promoting collagenesis and other benefits to skin.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: July 19, 2016
    Assignee: Allergan, Inc.
    Inventors: Futian Liu, Xiaojie Yu, Jessamine P. Winer-Jones, Nicholas J. Manesis, Hengli Liu, Gabriel Njikang
  • Patent number: 9353349
    Abstract: Cells incorporating a synthetic molecule construct of the structure F—S1-S2-L where: F—S1 is an aminoalkylglycoside where F is a mono-, di-, tri- or oligo-saccharide and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: May 31, 2016
    Inventors: Nicolai Bovin, Lissa Gilliver, Stephen Henry, Elena Korchagina
  • Patent number: 9321797
    Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: April 26, 2016
    Inventors: Anthony A. Sauve, Tianle Yang Redanz
  • Patent number: 9308215
    Abstract: The present invention relates to methods of treating a mycobacterial infection. In particular, this invention relates to methods, uses and compounds for use in treating mycobacterial infections, including tuberculosis. For example, the compounds may be an avermectin or a milbemycin. The avermectin or milbemycin may be selected from, but not limited to, one or more of ivermectin, moxidectin or selamectin. Exemplary microbial infections that may be treated include, but are not limited to, infections caused by Mycobacterium tuberculosis, Mycobacterium bovis, other mycobacteria of the tuberculosis complex, and non-tuberculous mycobacteria, including Mycobacterium ulcerans.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: April 12, 2016
    Inventors: Charles J. Thompson, Santiago Ramon-Garcia, Leah Elizabeth Lim
  • Patent number: 9296778
    Abstract: Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: March 29, 2016
    Assignees: Idenix Pharmaceuticals, Inc., Centre National De La Recherche Scientifique, Universite Montpellier 2 Sciences Et Techniques
    Inventors: Christophe Claude Parsy, Francois-Rene Alexandre, Cyril B. Dousson, David Dukhan, Gilles Gosselin, Houcine Rahali, Dominique Surleraux
  • Patent number: 9296831
    Abstract: The embodiments herein provide a method for isolation and purification of a novel oligosaccharide molecule from the fruits of Rosa arvensis for the treatment of diabetes. The fruit is dried, powdered and subjected to deionized water. The deionized water solution is subjected to silica gel column and the filtrate is subjected to ethanol-water mixture. The filtrate is subjected to column chromatography. The purified extract is structurally and chemically analyzed to find that the molecule is oligosaccharide. The purified oligosaccharide is administered to diabetic patients for 21 days. After the administration of oligosaccharide for 21 days the pancreatic tissues are collected and the blood glucose level in fasting and non fasting states is measured to find that there is significant effect in the blood glucose levels and the pancreatic tissue/cell regeneration after administration of the isolated oligosaccharide. The toxicity tests reveal that the oligosaccharide is non-toxic in nature.
    Type: Grant
    Filed: January 26, 2014
    Date of Patent: March 29, 2016
    Inventor: Gholamreza Bahrami
  • Patent number: 9290532
    Abstract: The present invention provides a novel sialo-sugar chain, a process for producing the sialo-sugar chain, and a device for producing the sialo-sugar chain. A sialo-sugar chain can be easily and efficiently mass-produced by reacting a sugar wherein a hydroxy groups is substituted with an alkynyl group (herein sometimes referred to as “alkynylated sugar”) with a specific sialic acid donor in the presence of a sialic acid-introducing enzyme.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: March 22, 2016
    Inventor: Masanori Yamaguchi
  • Patent number: 9271993
    Abstract: Novel pharmacological treatment of bacterial infectious diseases in humans by use of apramycin of formula (I) or apramycin derivatives having significantly low toxicity.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: March 1, 2016
    Inventors: Erik Boettger, Andrea Vasella
  • Patent number: 9265771
    Abstract: The present invention provides a method for treating Lyme disease and/or a Borrelia infection in animals comprising administering to an animal in need thereof a therapeutically effective amount of cefovecin.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: February 23, 2016
    Assignee: Zoetis Services LLC
    Inventors: Patrick F. M. Meeus, Christopher L. Haber
  • Patent number: 9259505
    Abstract: Biologically compatible polymers carry an imide and can be used as an adhesive, a hydrogel or both. A second biologically compatible polymer reactive with the imidated polymer can be used therewith to seal openings.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: February 16, 2016
    Assignee: The Johns Hopkins University
    Inventors: Jennifer H. Elisseeff, Iossif A. Strehin
  • Patent number: 9255120
    Abstract: The present invention is directed to methods for preparing sorbose from glucose, said method comprising: (a) contacting the glucose with a silica-containing structure comprising a zeolite having a topology of a 12 membered-ring or larger, an ordered mesoporous silica material, or an amorphous silica, said structure containing Lewis acidic Ti4+ or Zr4+ or both Ti4+ and Zr4+ framework centers, said contacting conducted under reaction conditions sufficient to isomerize the glucose to sorbose. The sorbose may be (b) separated or isolated; or (c) converted to ascorbic acid.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: February 9, 2016
    Assignee: California Institute of Technology
    Inventors: Mark E. Davis, Rajamani Gounder
  • Patent number: 9255301
    Abstract: A process for the crystallization of a water-soluble compound from a solution of water and a solvent is provided. A process for the manufacture of crystalline sucrose from sugar palm juice or sucrose-containing biomass comprising such crystallization process is also disclosed.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: February 9, 2016
    Assignee: Wageningen Universiteit
    Inventors: Johan Pieter Marinus Sanders, Marieke Elisabeth Bruins, Jeroen Johannes Cornelis Franciscus Van Bon
  • Patent number: 9249235
    Abstract: Methods of extracting chitin and chitosan from fungal biomass using a solution of one or more ammonia compounds, amines, and/or alkaline silicate compounds. The solution dissolves and extracts amino acids, fatty acids and other carbohydrates from the fungal cells leaving chitin and/or chitosan, and the extractant may be recovered from the liquid by simple phase changes such as heating or cooling, dissociation into volatile components, distillation and/or solidification and separation of immiscible extractants. Further lipid removal may be achieved with one or more organic solvents, which may also be recovered by distillation.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 2, 2016
    Inventors: Johannes Van Leeuwen, Glenn A. Norton, Sipho C. Ndlela, Daniel Rudnick
  • Patent number: 9241953
    Abstract: The present invention concerns the use of a glycosaminoglycan association of hyaluronic acid and chondroitin sulfate for the preparation of oral compositions for the prevention or for the treatment of upper gastro-intestinal tract disorders and for the preparation of upper gastro-intestinal epithelial damage, as well as the oral compositions comprising said glycosaminoglycan association.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: January 26, 2016
    Assignee: APHARM S.R.L.
    Inventor: Angelo Pizzoni
  • Patent number: 9242974
    Abstract: The present invention relates to processes and intermediates for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: January 26, 2016
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Guoyou Xu, Datong Tang, In Jong Kim, Ly Tam Phan, Yat Sun Or, Zhe Wang
  • Patent number: 9238071
    Abstract: An embodiment of the present disclosure provides a composition that comprises hyaluronic acid, or its salt or derivative thereof, and an antimicrobial agent, such as zinc citrate, that does not degrade the hyaluronic acid molecule.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: January 19, 2016
    Inventor: Karen K. Brown
  • Patent number: 9234225
    Abstract: A method for generating human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprising the steps of a) providing at least one donor selected from the group of compounds of any of formulae 5 to 10, b) providing at least one acceptor from a group of lactose, LNT, LNnT and derivatives thereof, c) providing at least one enzyme comprising a transglycosidase activity and/or a glycosynthase activity, d) preparing a mixture of the at least one donor, at least one acceptor and at least one enzyme provided in steps a), b) and c); and e) incubating the mixture prepared according to step d).
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: January 12, 2016
    Assignee: GLYCOM A/S
    Inventors: Gyula Dekany, Elise Champion, Andreas Schroven, Markus Hederos
  • Patent number: 9233122
    Abstract: An object of the present invention is to provide an agent for suppressing elevation of blood alcohol concentration and a method for suppressing elevation of blood alcohol concentration, the agent and the method enabling prevention of an intoxication state upon drinking and further prevention of hepatic dysfunctions due to drinking such as fatty liver. Provided are an agent for suppressing elevation of blood alcohol concentration, comprising a dextrin as an active ingredient, and a method for suppressing elevation of blood alcohol concentration, comprising, when alcohol is ingested, ingesting 0.5 parts by mass or more of a digestible dextrin and/or an indigestible dextrin relative to 1 part by mass of the ingested alcohol.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: January 12, 2016
    Inventors: Shoko Miyazato, Yuka Kishimoto
  • Patent number: 9226968
    Abstract: The invention relates to selected carbohydrate-lipid constructs and their use as mimics of ligands for receptors expressed by virus. In particular, the invention relates to the use of selected carbohydrate-lipid constructs in methods of inhibiting virus infection and/or promoting clearance of virus from infected subjects. Carbohydrate-lipid constructs selected for use in these methods where the virus is Human Immunodeficiency Virus (HIV) are provided.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: January 5, 2016
    Assignee: Kode Biotech Limited
    Inventor: Stephen Michael Henry