Abstract: The present invention relates to mesoporous organosilica nanoparticles, the method of preparation thereof, and uses of the same in treatment by means of photodynamic therapy or in imaging.
Type:
Grant
Filed:
January 18, 2017
Date of Patent:
June 1, 2021
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIER, NANOMEDSYN
Inventors:
Jean Olivier Durand, Jimenez Chiara Mauriello, Sebastien Richeter, Laurence Raehm, Magali Gary-Bobo, Marcel Garcia, Marie Maynadier
Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
Type:
Grant
Filed:
April 5, 2017
Date of Patent:
May 18, 2021
Assignee:
BRACCO IMAGING S.P.A.
Inventors:
Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
Type:
Grant
Filed:
July 22, 2020
Date of Patent:
May 18, 2021
Assignee:
GENERAL ELECTRIC COMPANY
Inventors:
Matthew David Butts, Jason William Castle, Andrew Soliz Torres, Jeannette Christine Roberts, Binil Itty Ipe Kandapallil
Abstract: Novel crystalline porous materials known as metal-organic frameworks (MOFs) and methods for their synthesis are provided herein. The MOFs include a M6(?3-OH)8(OH)8(?2,?2-(O2C)2cyclam)8 cluster, and a metal atom coordinated to the one or more cyclam of the cluster, wherein M is Zr or Hf, and the metal atom is any one of Cu, Ni, Cr, Ru, Co, and Gd. The MOFs can be used as an adsorbent, alone or in a medium with other components, of CO2. The MOFs can also be used as a catalyst for the transformation of CO2 and epoxides to cyclic carbonates. The MOFs can also be used in the electrochemical catalytic reduction of CO2. The MOFs can also be used for photocatalytic CO2 reduction for the production of carbon-based fossil fuels. The MOFs can also be used for light-induced nitric oxide (NO) release. The MOFs can also be used as magnetic resonance imaging (MRI) agents.
Type:
Grant
Filed:
August 20, 2019
Date of Patent:
May 4, 2021
Assignee:
Virginia Tech Intellectual Properties, Inc.
Abstract: Disclosed are compositions comprising polymeric nanoparticles and methods of using the same. The polymeric nanoparticles can be conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein. The polymeric nanoparticles can also comprises an imaging compound and/or a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle. A cancer therapeutic composition comprising the nanoparticle is also disclosed. The disclosed nanoparticles can be used to target and deliver imaging and/or therapeutic compounds to cancer cells, thereby identifying and/or treating a solid tumor cell target. Methods for treating cancer, such as lung cancer, using the polymeric nanoparticles are also disclosed.
Type:
Grant
Filed:
July 14, 2017
Date of Patent:
April 20, 2021
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance user identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.
Type:
Grant
Filed:
May 22, 2015
Date of Patent:
April 13, 2021
Assignee:
Varian Medical Systems, Inc.
Inventors:
Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Ronald Wojcik, Jacques Blummel, Alexander Kuller
Abstract: In some aspects, the present disclosure provides a dual emissive pH response noble metal nanoparticle which produces a ratiometric fluorescence signal based upon changes in the pH. In another aspect, the noble metal nanoparticle may be used in bioimaging applications as well as to detect in vivo changes of pH.
Type:
Grant
Filed:
April 27, 2015
Date of Patent:
March 23, 2021
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Abstract: Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
Type:
Grant
Filed:
June 28, 2007
Date of Patent:
February 23, 2021
Assignees:
Ceil>Point, LLC, The Board of Regents of the University of Texas System
Inventors:
David J. Yang, Dongfang Yu, Andrew S. Thompson
Abstract: The present invention provides a dual-purpose photoacoustic tomography (PAT)/ultrasound contrast agent comprising: (a) a micro-bubble containing gas and porphyrin therein; and (b) nanoparticles bound on a surface of the micro-bubble and containing a drug. The contrast agent of the present invention can be used in both the ultrasound diagnosis and the photoacoustic image diagnosis, and can significantly increase the accuracy of photoacoustic images.
Type:
Grant
Filed:
October 13, 2014
Date of Patent:
February 9, 2021
Assignee:
IMGT CO, LTD.
Inventors:
Hyun Cheol Kim, Hyung Won Moon, Jin Ho Chang
Abstract: The present invention relates to a method for sterilisation of phospholipid suspensions, useful in the preparation of ultrasound contrast agent precursors comprising phospholipid-stabilised perfluorobutane microbubbles. The method provides sterility assurance, without undue thermal degradation of the phospholipid. The method is also amenable to commercial scale manufacture. Also provided are methods of preparing kits and ultrasound contrast agents incorporating the sterilisation method of the invention.
Type:
Grant
Filed:
June 26, 2015
Date of Patent:
January 12, 2021
Assignee:
GE HEALTHCARE AS
Inventors:
Svein Kvale, Ingrid Henriksen, Ole Johannes Tokerud, Per Sontum
Abstract: The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.
Type:
Grant
Filed:
September 27, 2018
Date of Patent:
January 12, 2021
Assignee:
Lantheus Medical Imaging, Inc.
Inventors:
David S. Casebier, Simon P. Robinson, Ajay Purohit, Heike S. Radeke, Michael T. Azure, Douglas D. Dischino
Abstract: The present invention relates to a gas-generating micelle prepared by coupling a polyethylene glycol derivative and an alkyl chloroformate. The gas-generating micelles according to the present invention are circulated in the body and deposited on the disease site to generate carbon dioxide, and thus a more enhanced ultrasonic diagnostic image can be obtained.
Abstract: The present invention pertains generally to the field of imaging compounds, and more specifically to certain 2,2-dialkyl radionuclide-labelled carboxylic acids suitable for PET, SPECT and/or DNP imaging. Also described are used of such compounds in the imaging of inter alia, cancer tumours, metastasis, Alzheimer's disease and multiple sclerosis.
Type:
Grant
Filed:
February 21, 2019
Date of Patent:
November 3, 2020
Assignee:
Cancer Research Technologies Limited
Inventors:
Eric O. Aboagye, Lisa Iddon, Federica Pisaneschi, Timothy H. Witney
Abstract: Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
Type:
Grant
Filed:
July 31, 2012
Date of Patent:
October 27, 2020
Assignees:
The Board of Regents of the University of Texas System, Cell>Point, LLC
Inventors:
David J. Yang, Dongfang Yu, Andrew S. Thompson, F. David Rollo
Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
Type:
Grant
Filed:
December 11, 2017
Date of Patent:
October 6, 2020
Assignee:
BRACCO IMAGING S.P.A.
Inventors:
Valeria Boi, Roberta Napolitano, Luciano Lattuada, Giovanni Battista Giovenzana
Abstract: Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.
Type:
Grant
Filed:
July 5, 2019
Date of Patent:
September 29, 2020
Assignee:
Northwestern University
Inventors:
Thomas J. Meade, Matthew W. Rotz, Robert J. Holbrook
Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
Type:
Grant
Filed:
December 12, 2016
Date of Patent:
September 22, 2020
Assignee:
BRACCO IMAGING S.P.A.
Inventors:
Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
Abstract: The teachings provide methods of delivering active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Delivery systems and methods of making and using the delivery systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
Type:
Grant
Filed:
October 26, 2018
Date of Patent:
September 8, 2020
Assignee:
CHDI Foundation, Inc.
Inventors:
Celia Dominguez, John Wityak, Jonathan Bard, Christopher John Brown, Michael Edward Prime, Peter David Johnson, Thomas Martin Krulle, Daniel Clark-Frew, Duane Higgins, Matthew Robert Mills, Richard Waldron Marston, Samuel Coe, Samantha Brown, Sarah Hayes