Abstract: Provided are a preparation method of iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles, iron oxide-based nanoparticles prepared by the same, and a T1 contrast agent including the same. More particularly, the disclosure describes a method for preparation of iron oxide nanoparticles having a extremely small and uniform size of 4 nm or less based on thermal decomposition of iron oleate complex, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles prepared by the same, and a T1 contrast agent including iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles.
Type:
Grant
Filed:
August 5, 2011
Date of Patent:
January 9, 2018
Assignee:
Hanwha Chemical Corporation
Inventors:
Taeg Hwan Hyeon, Byung Hyo Kim, No Hyun Lee, Eung Gyu Kim, Bong Sik Jeon, Eun Byul Kwon, Ju Young Park, Wan Jae Myeong
Abstract: Photosensitive molecular switch, having a chelate ligand, a metal ion bonded coordinatively to the chelate ligand, the metal ion being selected from the group of metal ions consisting of Mn2+, Mn3+, Fe2+, Fe3+, Co2+ and Ni2+, a photochromic system which is bonded covalently to the chelate ligand and can be isomerized by irradiation, this system being bonded coordinatively to the metal ion in one configuration and not bonded to the metal ion in the other configuration.
Type:
Grant
Filed:
August 10, 2011
Date of Patent:
October 10, 2017
Assignees:
Christian-Albrechts-Universität zu Kiel, Universitätsklinikum Schleswig-Holstein
Inventors:
Rainer Herges, Olav Jansen, Felix Tuczek, Sugumar Venkataramani
Abstract: Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.
Type:
Grant
Filed:
December 21, 2004
Date of Patent:
September 5, 2017
Assignee:
Bracco Suisse S.A.
Inventors:
Michel Schneider, Philippe Bussat, Feng Yan, Anne Senente
Abstract: The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.
Type:
Grant
Filed:
September 4, 2015
Date of Patent:
August 1, 2017
Assignee:
Lantheus Medical Imaging, Inc.
Inventors:
David S. Casebier, Ajay Purohit, Heike S. Radeke
Abstract: Provided is a particle-stabilized ultrasound contrast agent (UCA) and methods of preparing same. Also provided is a method for preparing a lyoprotected UCA, a freeze-dried lyoprotected UCA, and a reconstituted freeze-dried lyoprotected UCA.
Type:
Grant
Filed:
September 20, 2010
Date of Patent:
July 11, 2017
Assignee:
Drexel University
Inventors:
Margaret A. Wheatley, Boriphat Methachan, Carl D. Solis
Abstract: The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.
Type:
Grant
Filed:
April 8, 2011
Date of Patent:
July 4, 2017
Assignee:
BRACCO IMAGING S.P.A.
Inventors:
Silvio Aime, Giovanni Battista Giovenzana, Fabio Tedoldi, Alessandro Maiocchi, Fulvio Uggeri, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Massimo Visigalli, Marco Crosetti, Luisa Poggi
Abstract: The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.
Type:
Grant
Filed:
December 3, 2012
Date of Patent:
July 4, 2017
Assignee:
BRACCO IMAGING S.P.A.
Inventors:
Silvio Aime, Sonia Colombo Serra, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi, Massimo Visigalli
Abstract: A dendrimer conjugate according to Formula (I), or its pharmaceutically acceptable salt, or solvate thereof: and complexes of Formula I conjugates with metals radionuclides of elements such as rhenium, technetium, yttrium, lutetium and others to provide a complex for imaging tissues or for the radiotherapeutic treatment of cancer tissue. Such complexes are specific to PSMA protein and can therefore be used in imaging or treating cancer of the prostate and other tissue where the protein is expressed.
Type:
Grant
Filed:
December 6, 2011
Date of Patent:
June 27, 2017
Assignee:
MOLECULAR INSIGHT PHARMACEUTICALS, INC.
Inventors:
John W. Babich, John L. Joyal, Craig Zimmerman
Abstract: The present invention provides a method for the treatment of malignant neoplasias comprising the step of administering an L-phenylalanine conjugated to a beta- or alpha-emitting isotope to a subject in the need thereof. Moreover, the invention provides a method for the monitoring of the progress of such treatment of malignant neoplasias.
Abstract: The disclosed subject matter includes methods of preparation, properties, pharmaceutical compositions and methods of therapy of sulfonated chlorins and bacteriochlorins designed for the photodynamic therapy (PDT) of hyperproliferative tissues such as tumors, hyperproliferative blood vessels and other disorders or abnormalies that are responsive to PDT. In particular, the economical large-scale synthesis of stable chlorins and bacteriochlorins is described. Their properties were tailored to meet those of ideal photosensitizers for PDT. In another embodiment, pharmaceutical compositions and methods of therapy for systemic administration are provided. In a further embodiment, pharmaceutical compositions and methods of therapy for topical administration are also provided. Further provided is a method of labeling a target tissue and providing an image of that tissue by fluorescence of magnetic resonance imaging.
Type:
Grant
Filed:
October 22, 2009
Date of Patent:
June 6, 2017
Assignee:
UNIVERSIDADE DE COIMBRA
Inventors:
Luis Guilherme Da Silva Arnaut Moreira, Maria Miguéns Pereira, Sebastião José Formosinho SanchesSimõs, Sérgio Paulo Magalhães Simões, Grazyna Stochel, Krystyna Urbanska
Abstract: Hyperpolarized samples (i.e., samples having fractional spin polarization P of at least 0.1) of a target molecular species are created through spin transfer from hyperpolarized xenon atoms or other source isotopes. Reversible nanoscale solid state contact is achieved between the hyperpolarized xenon atoms and molecules of a target species. The resulting solid state mixture is exposed to conditions of magnetic field and temperature designed to allow or even facilitate transfer of spin polarization from the xenon to the target molecules. The xenon and the target species are then separated under conditions that substantially preserve the polarization of the target species. The hyperpolarized target species can then be introduced into a subject of a nuclear magnetic resonance (NMR) experiment.
Abstract: The present invention provides methods and compositions based on optical sensor conjugates that are useful for detecting reactive oxygen, reactive nitrogen, or both species that are a direct result of inflammation caused by tissue damage.
Type:
Grant
Filed:
June 2, 2011
Date of Patent:
May 2, 2017
Assignee:
The General Hospital Corporation
Inventors:
Scott A. Hilderbrand, Ralph Weissleder, Peter Panizzi, Jason R. McCarthy
Abstract: The invention relates to aqueous dispersions, comprising particles based on a magnetic iron oxide with dimensions of ?20 nm, the surface of which is modified by the grafting of aminated groups R with a covalent bonding to the surface of said particles, wherein the isoelectronic point of particles with such a modified surface is ?10. The invention further relates to a method for production of said aqueous suspensions and a method for modification of the surface of the particles present in said dispersions, in particular, by the immobilisation of polysaccharides such as dextrans, particularly for the formulation of magnetic compositions which may be administered in vivo and in particular for the formulation of injectable compositions of contrast agents for MRI.
Type:
Grant
Filed:
May 13, 2004
Date of Patent:
April 25, 2017
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)
Inventors:
Etienne Duguet, Stéphane Mornet, Joseph Portier
Abstract: The present invention relates to MRI based imaging. In particular, the present invention provides MRI contrast agents targeted to a HaloTag protein with tunable relaxation properties thereby providing optimal relaxivity for low field strength imaging and the other optimal relaxivity for high field strength imaging. Moreover, the MRI contrast agents are used to detect gene expression (of a gene of interest) in real time in vivo, to detect changes in gene expression (of a gene of interest) over time in, for example, an individual organism, to detect gene expression changes (of a gene of interest) in response to therapeutics, in cell labeling for MR imaging, in clinical diagnostics, and in theranostics.
Type:
Grant
Filed:
March 29, 2013
Date of Patent:
March 7, 2017
Assignee:
Northwestern University
Inventors:
Thomas J. Meade, Renee C. Strauch, Luke F. Vistain
Abstract: Bone hemostat compositions, and methods for their use and manufacture are provided. Exemplary hemostatic compositions include polymeric components such as random and non-random copolymers, natural polymers, ceramics, reactive group polymers, and combinations thereof. Bone compositions may be used during surgical procedures, and may be applied to bone to inhibit or prevent bleeding from bone.
Abstract: The present invention discloses 18FDG conjugated positron emission tomography (PET) imaging agents. In particular, the present invention discloses a cancer specific 18FDG multimeric PET imaging agents.
Abstract: Image enhancing contrast agents for use in diagnostic and/or therapeutic methods, particularly in the form of gas-filled microvesicles, with enhanced stability. The gas-filled microvesicles are stabilized by a layer of amphiphilic material and comprise from 0.15% to 1.0% by moles of a lipid bearing a hydrophilic polymer. The lipid bearing a hydrophilic polymer is preferably a phospholipid linked to polyethyleneglycol.
Type:
Grant
Filed:
September 4, 2007
Date of Patent:
September 20, 2016
Assignee:
BRACCO SUISSE S.A.
Inventors:
Stephane Gorgerat, Christian Guillot, Feng Yan