Patents Examined by Leigh Maier
  • Patent number: 8110179
    Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: February 7, 2012
    Assignee: Cerulean Pharma Inc.
    Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
  • Patent number: 8088744
    Abstract: The invention provides a cancer chemotherapeutic agent which has fewer side effects and excellent efficacy. The cancer chemotherapeutic agent of the invention includes a cholestanol derivative represented by formula (1): (wherein G represents GlcNAc-Gal-, GlcNAc-Gal-Glc-, Fuc-Gal-, Gal-Glc-, Gal-, or GlcNAc-) or a cyclodextrin inclusion compound thereof, and an anti-cancer agent.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: January 3, 2012
    Assignees: Otsuka Pharmaceutical Co., Ltd., National University Corporation Gunma University
    Inventors: Shin Yazawa, Toyo Nishimura, Takayuki Asao
  • Patent number: 8088753
    Abstract: Heparin conjugates and methods of making and use thereof are disclosed. An illustrative heparin conjugate includes a composition wherein a bile acid is bonded to heparin through the 3-carbon of the bile acid. A spacer may be interposed between the bile acid and the heparin. Another embodiment includes a targeting moiety bonded to the heparin-bile acid conjugate through a spacer. Another illustrative heparin conjugate includes heparin covalently bonded to a sulfonated moiety, such as a naphthalene trisulfonate residue. A method of treating cancer includes administering a heparin conjugate to an individual in need thereof.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: January 3, 2012
    Assignee: Mediplex Corporation, Korea
    Inventors: Youngro Byun, E Sak Lee, Ok-cheol Jeon, Sang Yoon Kim, Rang-Woon Park
  • Patent number: 8071557
    Abstract: This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating pulmonary hypertension comprising administering a therapeutically effective dose of a carbonic anhydrase inhibitor to a patient in need of treatment. The disclosure finds utility in the fields of medicine and pharmacology.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: December 6, 2011
    Assignee: Vivus, Inc.
    Inventors: Thomas Najarian, Peter Y. Tam, Leland F. Wilson, Craig Peterson
  • Patent number: 8044035
    Abstract: A trioxopyrimidine-cyclodextrin complex formed of a trioxopyrimidine derivative or a salt thereof and a water-soluble cyclodextrin derivative has improved solubility.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: October 25, 2011
    Assignee: Universite De Liege
    Inventors: Pierre Bartsch, Didier Cataldo, Richard Endele, Brigitte Evrard, Jean-Michel Foidart, Hans-Willi Krell, Gerd Zimmermann
  • Patent number: 8039442
    Abstract: Compounds, compositions and methods are provided for treatment of sickle cell disease or a complication associated therewith, or graft versus host disease, in an individual. More specifically, the use of particular glycomimetics for the treatment is described.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: October 18, 2011
    Assignee: GlycoMimetics, Inc.
    Inventor: John L Magnani
  • Patent number: 8039447
    Abstract: The present invention relates to the use of a compound having the formula (I) wherein: n represents an integer varying from 720 to 6 200, and i varies from 1 to n, Ri represents in particular OH, or a group of the formula (III) wherein k represents an integer varying from 1 to 17, and R?i represents a linear or branched alkyl chain comprising p carbon atoms, wherein p is an integer varying from 1 to 17, with the proviso that k+p is not greater than 28, and preferably not greater than 20, and wherein at least one Ri group represents a group of formula (III), for the preparation of a viscoelastic composition.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: October 18, 2011
    Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Agro Industrie Recherches et Developpements A.R.D.
    Inventors: Marguerite Rinaudo, Rachel Auzely, Shirin Kadi, Anthony Bresin, Erell Kubik
  • Patent number: 8026222
    Abstract: Methods are provided for using a compound to treat, for example, endothelial dysfunction including vascular abnormalities. More specifically, methods are described for using an oligosaccharide compound or glycomimetic compound wherein a cyclohexane derivative is incorporated in either.
    Type: Grant
    Filed: February 7, 2008
    Date of Patent: September 27, 2011
    Assignee: GlycoMimetics, Inc.
    Inventor: John L. Magnani
  • Patent number: 8017657
    Abstract: A composition and method for pain relief and the treatment and prevention of endothelial dysfunction the cause of atherosclerosis, cardiovascular disease, hypertension, and stroke in mammals comprising a therapeutically effective amount of anti-inflammatory agents comprising; NSAIDs, an amino sugar and a zinc compound combined with dietary supplements that may enhance longevity.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: September 13, 2011
    Assignee: Advanced Medical Instruments
    Inventor: Edward Joseph Petrus
  • Patent number: 7994155
    Abstract: The present invention has an object to provide an accelerator for mineral absorption and a composition containing the accelerator. The object is solved by providing an accelerator for mineral absorption comprising cyclic tetrasaccharide and/or saccharide derivatives thereof and a composition containing the accelerator.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: August 9, 2011
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kaguku Kenkyujo
    Inventors: Kazuyuki Oku, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 7977318
    Abstract: An O-acyl product derived from glucose which may be obtained by partial or total esterification of glucose and of vitamin F, comprising a mixture of esters, for example, monoesters, of glucose and of at least one acid chosen from linoleic acid, oleic acid, palmitic acid and stearic acid, compositions, for example, cosmetic and pharmaceutical compositions, comprising this novel derivative, and their use for improving the condition of head hair and/or other hairs, and, for example, for reducing and/or impeding the loss of head hair and/or other hairs, and/or for inducing and/or stimulating hair growth, as well as a process for preparing O-acyl derivatives mainly in position 6 of glucose, comprising preparing a mixed anhydride by reacting a carboxylic acid with a trimethylacetyl halide, followed by reacting said mixed anhydride formed with glucose.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: July 12, 2011
    Assignee: L'Oreal S.A.
    Inventors: Jean-François Michelet, Maria Dalko, Bruno Bernard, Didier Semeria, Michel Philippe
  • Patent number: 6451767
    Abstract: This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10, are each, independently, hydrogen, acyl of 2-7 carbon atoms, perfluoroacyl of 2-10 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, benzoyl, benzyl or —SO3M; M is hydrogen, lithium, sodium, potassium or ammonium; R11 is hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, halogen, nitrile, nitro, or alkoxy of 1-6 carbon atoms; R12 is hydrogen, nitro, amino, acylamino of 2-7 carbon atoms, perfluoroacylamino of 2-7 carbon atoms, alkylamino of 1-6 carbon atoms, perfluoroalkylamino of 1-6 carbon atoms, dialklylamino where each alkyl chain is independently 1-6 carbon atoms, perfluorodialklylamino where each alkyl chain is independently 1-6 carbon atoms alkylsulfonylamino of 1-6 carbon atoms, perfluoroalkylsulfonylamino of 1-6 carbon atoms, arylsulfonylamino of 6-10 carbon atoms or arylsulfonylamin
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: September 17, 2002
    Assignee: Wyeth
    Inventor: Paul J. Dollings
  • Patent number: 6242636
    Abstract: An electoclinic device having two spaced cell walls each bearing electrode structures and treated on at least one facing surface with an alignment layer, a layer of a smectic liquid crystal material enclosed between the cell walls, where the liquid crystal material contains one or more of the compounds described by formula I as defined in the specification.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: June 5, 2001
    Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britian and Northern Ireland of Defence Evaluation and Research Agency
    Inventors: Andrew John Slaney, Damien Gerard McDonnell, Amarjit Kaur Samra, Maurice Stanley, Victoria Minter, John William Goodby, Michael Hird, Simon John Cross, Chu Chuan Dong