Patents Examined by Leon B. Lankford, Jr.
  • Patent number: 7074578
    Abstract: This invention relates to the methylation of histones, in particular to a previously uncharacterised group of histone H3 methylases which comprise a SET domain and which methylate either lysine 4 within the amino tail of histone H3 or within the histone H3 core. Methylation by these methylases, in particular trimethylation, is shown to be important for transcriptional activity.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: July 11, 2006
    Assignee: Chroma Therapeutics LTD
    Inventors: Tony Kouzarides, Helena Santos-Rosa
  • Patent number: 7074552
    Abstract: A method for constructing a stable bioactive mammalian embryonic kidney is described herein. A kidney so constructed requires no artificial support, nor porous man made membranes or tubing to effectuate its biological function of filtering body fluids. A single donor embryonic kidney, or fragment thereof, can produce a great number of functional kidneys suitable for treating subjects with various kidney disorders. It is anticipated that said in vitro produced kidney would be less, or not at all, antigenic when transplanted into a subject, because of its embryonic character and artificial propagation in culture. This method of producing a functional organ can be useful in cloning other organ structures containing inducible epithelial tissues.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: July 11, 2006
    Assignee: The Regents of the University of California
    Inventors: Sanjay Kumar Nigam, Jizeng Qiao, Hiroyuki Sakurai
  • Patent number: 7070968
    Abstract: The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases.
    Type: Grant
    Filed: February 24, 2003
    Date of Patent: July 4, 2006
    Assignees: ARCH Development Corporation, Dana Farber Cancer Institute
    Inventors: Donald Kufe, Ralph R. Weichselbaum
  • Patent number: 7070965
    Abstract: A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.
    Type: Grant
    Filed: April 14, 1999
    Date of Patent: July 4, 2006
    Inventor: Zhenhua Yang
  • Patent number: 7070953
    Abstract: The invention relates to a method for enzymatically obtaining protein hydrolysates for human consumption, animal feed and cosmetics. The process involves the use of a proteolytic composition derived from fish, such as Cod (Gadus morhua), to obtain hydrolysates which have a non-bitter taste and retain the flavor and aroma of the protein-containing material which is hydrolyzed: e.g. when hydrolyzing protein-containing material from marine organisms or parts thereof, such as fish, shrimp, lobster or other seafood according to the invention, a protein hydrolysate is produced that has a characteristic natural flavor of the organism Also provided are food products comprising the hydrolysates of the invention, such as soup, sauce, cheese, HVP, meat extract and flavoring agent, broth, paté, mousse, frying dough, orly dough, and pastries.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: July 4, 2006
    Assignee: Nordur EHF
    Inventors: Jon Bragi Bjarnason, Bergur Benediktsson
  • Patent number: 7067104
    Abstract: The present invention is focused on a revolutionary, low-cost (highly-scaleable) approach for the mass production of three-dimensional microcomponents: the biological reproduction of naturally-derived, biocatalytically-derived, and/or genetically-tailored three-dimensional microtemplates (e.g., frustules of diatoms, microskeletons of radiolarians, shells of mollusks) with desired dimensional features, followed by reactive conversion of such microtemplates into microcomponents with desired compositions that differ from the starting microtemplate and with dimensional features that are similar to those of the starting microtemplate. Because the shapes of such microcomponents may be tailored through genetic engineering of the shapes of the microtemplates, such microcomposites are considered to be Genetically-Engineered Materials (GEMs).
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: June 27, 2006
    Assignee: The Ohio State University
    Inventor: Kenneth H. Sandhage
  • Patent number: 7060292
    Abstract: This invention features in vitro methods of determining the rate and extent to which test compounds, such as drug candidates, enter, move within, and traverse lipid-associated barriers. This invention also features method that measure the accumulation, that is the partition coefficient, of test compounds in lipid structures relative to, e.g., an aqueous phase, as well as the rate of accumulation of test compounds in the lipid structures. In addition, the invention features lipid vesicles that contain fluorophores localized within the aqueous interior that can be employed in the methods described herein.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: June 13, 2006
    Assignee: GESynthesis, Inc.
    Inventors: Donald L. Melchior, Anthony Carruthers
  • Patent number: 7060474
    Abstract: The properties of dough or bread can be improved by the addition of a carbohydrate oxidase which can oxidize the reducing end of an oligosaccharide more efficiently than the corresponding monosaccharide, e.g., preferentially oxidizing maltodextrins or cellodextrins over glucose. A novel carbohydrate oxidase having the capability to oxidize maltodextrins and cellodextrins more efficiently than glucose may be obtained from a strain of Microdochium, particularly M. nivale. The amino acid sequence of the novel carbohydrate oxidase has very low homology (<20% identity) with known amino acid sequences.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: June 13, 2006
    Assignee: Novozymes A/S
    Inventors: Palle Schneider, Søren Christensen, Lone Dybdal, Claus Crone Fuglsang, Feng Xu, Elizabeth Golightly
  • Patent number: 7060492
    Abstract: Highly undifferentiated spore-like cells can be isolated from many different tissues and bodily fluids after those tissues and fluids have been exposed to extreme conditions. The spore-like cells can be used to treat a wide variety of disorders.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: June 13, 2006
    Assignee: VBI Technologies, L.L.C.
    Inventors: Charles A. Vacanti, Martin P. Vacanti
  • Patent number: 7060494
    Abstract: A method of isolating and growing human mesenchymal stem calls (hMSC) by culturing human stem cells in human umbilical cord blood serum. For this purpose blood is collected from the umbilical cord at the time of birth, after the infant is separated from the umbilical cord, and the blood is collected from an umbilical vein free of anticoagulants. The blood is collected in a blood bag having a collecting needle which is inserted into the umbilical vein and the blood is allowed to flow from the vein into the blood bag, and the blood is allowed to clot at room temperature and the bag is transported to a processing area which is a cGMP clean room.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: June 13, 2006
    Assignee: Reliance Life Sciences Pvt. Ltd.
    Inventor: Aravind Venkatrao Bhat
  • Patent number: 7049109
    Abstract: A method of producing 1,2-propandiol is provided. The method includes incubating Klebsiella pneumoniae in a medium containing 10–30 g/L of a sugar carbon source excluding 6-deoxyhexose, in aerobic conditions; and separating 1,2-propandiol from the cultures. Using the method, 1,2-propandiol can be produced with a high yield by incubating Klebsiella pneumoniae in a medium containing a cheaper sugar carbon source.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: May 23, 2006
    Assignee: CJ Corp.
    Inventors: Young Hoon Park, Jin Su Chung, Kwang Myung Cho, Seong Uk Kang, Hye Won Um
  • Patent number: 7049086
    Abstract: The present invention provides a high-throughput screening assay to identify test agents as cholesterol inhibitors via mutant NCP1 mammalian cells. Also provided are cholesterol inhibiting agents identified in accordance with this assay and methods for using such agents to inhibit cholesterol accumulation in cells.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: May 23, 2006
    Assignee: Trustees of Dartmouth College
    Inventor: Ta-Yuan Chang
  • Patent number: 7045349
    Abstract: Advanced Islet Separation Technology incorporates an automated method, automated control methodology, process control interface, and automated apparatus to separate (isolate) and process pancreatic islets in a tissue suspension in physiologic process solution, utilizing microprocessor controllers and computer control and software programming to interface and control the process temperature, process flowrate, percent hydrogen concentration, dissolved oxygen concentration, endotoxin concentration, dissolved nitric oxide concentration, nitric oxide synthase concentration, proteolytic enzyme activity, and pressure of the islet containing physiologic process solution, including real-time process data acquisition and recording of the process variables.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: May 16, 2006
    Inventors: Daniel J. Benedict, Lorna S. Mosse
  • Patent number: 7045125
    Abstract: Biologically active composites containing calcium phosphate, more specifically beta-tri-calcium phosphate, and methods of preparing the same are disclosed herein. Also disclosed are methods of restoring an osseous void and complimentary kits for the disclosed composites.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: May 16, 2006
    Assignee: Vita Special Purpose Corporation
    Inventors: Erik M. Erbe, Jeffrey G. Marx
  • Patent number: 7045279
    Abstract: An isolated heart preparation in which essentially normal pumping activity of all four chambers of the heart is preserved, allowing for the use of the preparation in conjunction with investigations of electrode leads, catheters, cardiac implants and other medical devices intended to be used in or on a beating heart. The preparation may also be employed to investigate heart functions, in the presence or absence of such medical devices. In order to allow for visualization of heart structures and devices located within the chambers of the heart, a clear perfusate such as a modified Krebs buffer solution with oxygenation is circulated through all four chambers of the heart and the coronary vasculature. The preparation and recordings of the preparation may be used in conjunction with the design, development and evaluation of devices for use in or on the heart, as well as for use as an investigational and teaching aid to assist physicians and students in understanding the operation of the heart.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: May 16, 2006
    Assignee: Medtronic, Inc.
    Inventors: Timothy G. Laske, Paul A. Iaizzo, Mark A. Hjelle, Josée Morissette, Dale A. Wahlstrom
  • Patent number: 7041439
    Abstract: Methods and apparatus for processing eggs based upon a characteristic such as gender are provided. Material is extracted from each of a plurality of live eggs, the extracted material is assayed to identify eggs having the characteristic, and then eggs identified as having the characteristic are processed accordingly.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: May 9, 2006
    Assignee: Embrex, Inc.
    Inventors: Patricia V. Phelps, B. Alan Chalker, II, William Hayes Ferrell, III, John H. Hebrank, Benjamin Charles McDow, Edward Atkinson Pomeroy, III, Jonathan Robertson, Johnny Mark Townsend
  • Patent number: 7041501
    Abstract: The present invention relates to methods of screening drug candidates for toxic effects on human cells. The invention provides methods for determining idiosyncratic toxicity of test compounds.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: May 9, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Oliver P. Flint, Frederic Moulin, Stephen K. Durham
  • Patent number: 7037534
    Abstract: Described herein is an invention that relates to chemiluminescence-directed antiviral activities of natural and synthesized light-sensitive compounds. Methods are described herein for inactivating infectious virus particles outside and inside an organism. These methods incorporate coupling the antiviral activity of various light-sensitive compounds with chemiluminescence directed by native as well as foreign enzymes of the organism and enhanced by the addition of various anti-quenchers and wavelength-shifting compounds. The methods described herein feature light-sensitive compounds with known antiviral activity exhibited in the presence of light.
    Type: Grant
    Filed: October 24, 2002
    Date of Patent: May 2, 2006
    Assignee: Aphios Corporation
    Inventors: Trevor Castor, Lisa Bastiani Lallos, Petr O. Ilynskii
  • Patent number: 7037708
    Abstract: Dry microorganism cultures comprising at least one microorganism species in carrier-bound form are present in the form of particles which a) have a particle size of at least about 0.1 mm and b) are compressed; processes for preparing dry microorganism cultures and their use for preparing foodstuffs and feedstuffs are also claimed.
    Type: Grant
    Filed: April 29, 1999
    Date of Patent: May 2, 2006
    Assignee: BASF Aktiengesellschaft
    Inventors: Frank Runge, Bryan Cooper, Ulrich Bröckel, Robert Heinz, Hans-Peter Harz, Ulrich Eidelsburger, Bruno Käsler, Thomas Keller
  • Patent number: 7037694
    Abstract: A method for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins. A method is also provided for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: May 2, 2006
    Assignee: I. Belloch Corp.
    Inventors: Yuri Vasilyevich Aksenov, Michael Nikolaevich Ivanovsky, Nikolai Ivanovich Loginov, Albina Vasilyevna Milovidova, Valentine Alexeevich Morozov, Nikolai Nikolaevich Ponomarev-Stepnoi, Boris Alexandrovich Chulkov, Alexander Lvovich Shimkevich, Joel B. Grae