Patents Examined by Leon Blaine Lankford
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Patent number: 8337834Abstract: Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Compositions that are administered to a patient include a mixture of adipose tissue and stem cells so that the composition has a higher concentration of stem cells than when the adipose tissue was removed from the patient.Type: GrantFiled: March 7, 2011Date of Patent: December 25, 2012Assignee: Cytori Therapeutics, Inc.Inventors: John K. Fraser, Marc H. Hedrick
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Patent number: 7189568Abstract: The present invention provides a method of clonal propagation of Pandanus amaryllifolius and further provides a composition for the clonal propagation of scented Pandanus amaryllifolius.Type: GrantFiled: November 12, 2004Date of Patent: March 13, 2007Assignee: Council of Scientific and Industrial ResearchInventors: Bhagyalakshmi Neelwarne, Thimmaraju Rudrappa, Mandayam Singara Narayan, Gokare Aswathanarayana Ravishankar
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Patent number: 7186555Abstract: The present invention provides methods and pharmaceutical compositions of the human glycoprotein fetuin, or ?2-HS glycoprotein, or fragments thereof to mitigate tissue damage associated with ischemia, particularly in stroke or in myocardial infarction.Type: GrantFiled: April 13, 2000Date of Patent: March 6, 2007Assignee: The Feinstein Institute for Medical ResearchInventors: Kevin J. Tracey, Haichao Wang
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Patent number: 7176023Abstract: A method is described to induce primate embryonic stem cells to differentiate into a relatively homogenous population of endothelial cells. The ES derived endothelial cells have the general morphological and cell surface marker characteristics of endothelial cells. The ES derived endothelial cells also are capable of inducing and participating in blood vessel formation (or vascularization) when transplanted into tissue in vivo.Type: GrantFiled: November 1, 2002Date of Patent: February 13, 2007Assignee: Wisconsin Alumni Research FoundationInventors: Dan S. Kaufman, Rachel Lewis, Robert Auerbach
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Patent number: 7175842Abstract: The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.Type: GrantFiled: May 13, 2005Date of Patent: February 13, 2007Assignee: The General Hospital CorporationInventors: Bruce A. Morgan, Jiro Kishimoto, Robert Burgeson
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Patent number: 7169607Abstract: The invention features a liver cell culture comprising hepatocytes that have increased detoxification enzyme activity when isolated from a liver of a donor that had been administered at least one induction agent prior isolation of hepatocyte cells. The induced hepatocytes are used in a bioreactor and cultured to produce hepatocyte cell products or metabolize toxins added to the culture. The bioreactor is, or is an integral part of, a liver assist device used to treat a patient in need of liver assist.Type: GrantFiled: June 27, 2003Date of Patent: January 30, 2007Assignee: Organogenesis, IncInventors: Susan J. Sullivan, Paul G. Gregory, Paul A. DiMilla
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Patent number: 7157082Abstract: The present invention relates to methods and compositions related to the use of enzymes of the allene oxide synthase family for reducing myocardial ischemia reperfusion injury associated with myocardial infarction, thrombolysis, angioplasty and coronary bypass surgery. The methods of the invention comprise administration of allene oxide synthases, which are capable of eliminating lipid hydroperoxides, as a potent cardioprotective agent. The invention is based on the discovery that administration of allene oxide synthase following severe global ischemia stimulates cardiac recovery.Type: GrantFiled: July 30, 2003Date of Patent: January 2, 2007Assignee: Arizona Board of RegentsInventor: Ralph A. Backhaus
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Patent number: 6797508Abstract: The invention relates to bioreactor for fermenting solid substrates, comprising a fermentation vessel (2), a device for feeding bioreactive substances and a nozzle arrangement in the fermentation vessel (2). The invention is characterized in that a nozzle arrangement (10, 20) consisting of a plurality of pipes (14, 24) which project into the reaction chamber (49) of the fermentation vessel (2) in parallel and which are provided with nozzles (16, 28) is situated in the fermentation vessel (2). The invention also relates to a method for aerobically fermenting solids. A reaction medium containing these solids is mixed using a compressed gas (48) which is guided into the reaction mixture from above.Type: GrantFiled: July 31, 2002Date of Patent: September 28, 2004Assignee: Hofer Bioreact GmbHInventor: Udo Hölker
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Patent number: 5387109Abstract: Disclosed are a novel fructosylamine deglycase characterized by the specificity to amadori compounds of catalyzing oxidation of the compounds to produce an .alpha.-ketoaldehyde, an amine derivative and hydrogen peroxide; a method of producing the novel enzyme by cultivating microorganisms belonging to the genus Candida and having an ability of producing the novel enzyme; and a method of quantitative determination of amadori compounds by applying the novel enzyme to a sample containing amadori compounds to measure the amount of the hydrogen peroxide to be formed by the oxidation reaction or measure the amount of the oxygen to be consumed by the reaction to thereby obtain the amount of the amadori compounds from the measured value. The invention provides a novel enzyme characterized by the high specificity to the reaction with amadori compounds, especially that having therein a saccharide moiety as bonded to the .epsilon.Type: GrantFiled: May 24, 1993Date of Patent: February 7, 1995Assignee: Nakano Vinegar Co., Ltd.Inventors: Atsushi Ishikawa, Yoshifumi Ohshima, Mikio Yamada, Hajime Okumura, Yoshiya Kawamura