Patents Examined by Leonard M. Williams
  • Laulimalide microtubule stabilizing agents
    Patent number: 7435754
    Abstract: A method of inhibiting the proliferation of a hyperproliferative mammalian cell having a multiple drug resistant phenotype utilizing an amount of a laulimalide compound effective to disrupt the dynamic state of microtubule polymerization and depolymerization to arrest cell mitosis is disclosed, together with laulimalide compounds which find use in such method.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: October 14, 2008
    Assignees: Utah State University, University of Hawaii
    Inventors: Susan L. Mooberry, Bradley S. Davidson