Abstract: A superior soft tissue product, such as facial tissue, bath tissue or paper towels and the like, can be made applying, on the surface(s) of the tissue, large numbers of individual deposits of a melted hydrophilic composition comprising a high molecular weight polyethylene glycol, a fatty alcohol (C.sub.14 -C.sub.30) and lipophilic emollients or solvents, including water, and thereafter resolidifying the composition to form a distribution, preferably a uniform distribution, of solid deposits on the surface(s) of the tissue. Because the composition is a solid at room temperature and rapidly solidifies after deposition, it has less tendency to penetrate and migrate into the sheet. These solid deposits are characterized by a penetration hardness of from about 5 to about 360 millimeters.

Abstract: Ketoconazole is used for treating cocaine addiction. Mammals, including humans, that are chronically addicted to cocaine are treated with ketoconazole to decrease self-administration of the drug.

Abstract: Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.

Abstract: A method for the topical treatment of skin affected with a dermatological condition selected from the group consisting of impetigo, epidermolysis bullosa, eczema, neurodermatitis, psoriasis, pruritis, erythema, hidradenitis suppurativa, warts, diaper rash, jock itch, and combinations thereof. For most conditions, sodium chloride, in a substantially pure form as a solid block, is topically applied to the affected skin by gently gliding the block over the affected skin in a manner insufficient to cause abrasion and debridement of the affected skin. For certain conditions, such as epidermolysis bullosa, sodium chloride in the form of an aqueous solution preferably should be used. The applied sodium chloride is left on the skin.

Abstract: An improved skin treatment composition is provided. The composition comprises calamine in an amount between about 8% and 20%, an antioxidant in an amount between about 0.05 and 3 weight percent; and an herbal anti-bacterial substance in an amount between about 0.25 and 4 weight percent. These ingredients are combined with a base, preferably comprised of water and glycerin, in order to prepare the inventive composition. The base will generally comprise from between 25% and 60% by weight of the overall composition.

Abstract: A therapeutical method for the treatment of Attention-Deficit/Hyperactive Disorder (ADHD) is disclosed which comprises administering to a child in need thereof L-carnitine or an alkanoyl L-carnitine or a pharmacologically acceptable salt thereof.

Abstract: The invention discloses 3-ketosteroids of the following formula used to inhibit steroid 5.alpha.-reductase: ##STR1## wherein R is OH, C.sub.1 -C.sub.6 alkanoyl, C.sub.1 -C.sub.6 alkanoyloxy, C.sub.1 -C.sub.4 alkanol, COCH.sub.2 OH, CO.sub.2 H, CONR.sub.7 R.sub.8, cyclopropoxy, acetylthioalkane, cyclopylamino, 2-2-dimethyldioxolan-4-yl, 1,2-dihydroxyethyl and C.sub.1-4 alkanethiol;R.sub.1 is hydrogen, hydroxy or C.sub.1-6 alkyl;R.sub.1 and R.sub.2 together may indicate .dbd.O, that is an oxygen double bonded to the 17 carbon;R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen or C.sub.1-6 alkyl;R.sub.5 and R.sub.6 are each independently hydrogen or OH;R.sub.5 and R.sub.6 together may indicate .dbd.O, that is an oxygen double bonded to the 11 carbon;R.sub.7 is hydrogen or C.sub.1-8 alkyl;R.sub.8 is C.sub.1-8 alkyl; andwith the proviso that, when R is OH, then R.sub.1 is hydrogen; and with the proviso that, when R.sub.5 is OH, then R.sub.6 is hydrogen.

Abstract: A composition for the treatment of diabetes and a method of use thereof. composition includes an immunoregulator, preferably Linomide, and a .beta. cell proliferative agent, preferably reg protein. The composition has been shown to be effective in both inhibiting the progression of diabetes, and reversing the course of the disease, in the NOD mouse model.

Abstract: A method for inducing angiogenesis in blood vessels proximal to ischemic tissue or proximal to stenosed regions including application of an estrogen compound to the blood vessel walls at a treatment site proximal to or upstream of the stenosis. A preferred delivery device is a double walled drug delivery catheter having porous outer walls. Another suitable delivery device is a drug injection device for injecting angiogenic material into blood vessel walls. One delivery method utilizes iontophoresis.

Abstract: A method for treating symptoms of patients diagnosed with tardive dyskinesia (TD) using NMDA receptor antagonists is disclosed. This invention illustrates that certain NMDA-receptor antagonists are effective pharmacologic agents in the treatment of hyperkinesia and cognitive disorders that present in patients diagnosed with TD. The disclosed agents reduce the severity and duration of involuntary movements associated with tardive dyskinesia. Certain of the disclosed agents are also effective in increasing the attention span, concentration span, memory and everyday functional performance as measured both subjectively as well as objectively as demonstrated using standard neuropsychological tests such as those assessing reaction time and short-term memory. The invention also discloses a method of treating tardive dyskinesia that acts in a neuroprotective manner to reduce or prevent glutamate-related excitotoxic damage to the basal ganglia.

Abstract: Liquid, oil-miscible carotenoid preparations which, as double dispersion systems, comprise an aqueous-disperse phase which has a particle diameter of less than 100 .mu.m and in which particles, stabilized by protective colloid, of one or more carotenoids are present in disperse form, in an oil as a dispersion medium.

Abstract: An improved skin conditioner, incorporating alpha hydroxy acids, is an emulsion stabilized by the combination of a high molecular weight polyethylene glycol and a quaternary ammonium salt phosphate cationic surfactant, specifically, an alkyl amidopropyl PG-Dimonium Chloride phosphate type cationic surfactant. The composition may include other active agents, non-ionic emulsifying surfactants, emollients and additives. The resulting composition has a desirable "feel" and storage stability, even at relatively high temperatures.

Abstract: A therapeutical method is disclosed for treating idiopathic asthenozoospermia which comprises orally or parenterally administering to a patient in need thereof a combination preparation comprising in admixture L-carnitine and acetyl L-carnitine or the pharmacologically acceptable salts thereof, in substantially equimolar amouts.

Abstract: A method and a device for the treatment of wounds and promotion of wound healing and muscle regeneration. The method includes applying a composition including a non-biodegradable microsphere with a substantial surface charge to the subject. The device further includes a pharmaceutically acceptable carrier and a container for containing the composition and the carrier. The microspheres used in the present invention have been shown to promote wound healing and muscle regeneration both in vivo and in vitro.

Abstract: A method useful for the treatment of itching is disclosed. The method comprises applying an effective amount a 1,4-naphthoquinone to the affected area of the skin. The 1,4-naphthoquinone is hydroxy or keto at the 2 position or the 3 position, or a juglone. A composition comprising an effective amount of the 1,4-naphthoquinone, and a kit for conducting the method are also provided.

Abstract: A Novel composition and a method for treating anorectal diseases including hemorrhoids and colonic diseases with long term effectiveness and low prolapse rates is disclosed. The compositions are water soluble and can be uniformly applied in the affected region. The composition comprises Flavonoidal constituents which possess anti-inflammatory properties.

Abstract: A personal cleansing composition comprising:(a) from about 1% to about 20% by weight of anionic sulphate or sulphonate surfactant;(b) from about 0.1% to about 10% by weight of carboxymethylated C.sub.8 -C.sub.22 alkyl or alkenyl monoethanolamide polyglycol ether;(c) from about 0.1% to about 10% by Weight of zwitterionic and/or amphoteric surfactants; and(d) from about 0.1% to about 20% by weight of a soluble or dispersible nonionic surfactant selected from ethoxylated animal and vegetable oils and fats and mixtures thereofThe cleaning products demonstrate excellent mildness, conditioning benefits, stability, lathering and rinsibility.

Abstract: A gelatinous external skin treatment composition comprising (1) spherical powder of organopolysiloxane elastomer having an average particle size of 1.0 to 15.0 .mu.m, (2) silicone oil and (3) polyether modified silicone having the formula (I): ##STR1## wherein A represents a methyl group, phenyl group, or B explained below, B is a polyoxyalkylene group having the formula:--C.sub.3 H.sub.6 O(C.sub.2 H.sub.4 O).sub.a (C.sub.3 H.sub.6 O).sub.b R',wherein R' is a group selected from the group consisting of a hydrogen atom, acyl group, and C.sub.1 to C.sub.4 alkyl groups, a is an integer of 5 to 50, and b is an integer of 5 to 50,R is a methyl group or phenyl group, m is an integer of 50 to 1000, and n is an integer of 0 to 40, provided that at least one polyoxyalkylene group is present in the molecule, and optionally (4) a lower alcohol having 3 carbon atoms or less and/or water.

Abstract: Metabolites of the D-isomer of propranolol show potent antioxidant activity, independent of .beta.-blocker activity, that make them useful for the treatment of all conditions that can be treated by antioxidants, or any disease that is responsive to antioxidant treatment, for example, diseases or disorders of the cardiovascular system, heart failure, myocardial infraction, atherosclerosis, stroke, hypertension, ischemia/reperfusion injury an inflammatory processes.

Abstract: A nutritional composition for providing glutamine to a human or animal. The protein source of the composition includes carob protein which is rich in glutamine. A source of Met may also be included. The composition may be used in the treatment of stressed patients; for example those patients who are critically ill, suffering from sepsis, injury, burns, or inflammation, or who are recovering from surgery. Further, the composition may be used to raise plasma glutamine levels; for example in athletes after intense exercise.