Patents Examined by Leslie Alexandra Royds
  • Supramolecular complexes as photoactivated DNA cleavage agents
    Patent number: 6962910
    Abstract: The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e.g. Ru or Os) to an electron accepting metal (e.g. Rh) via a bridging ?-acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated. The complexes function when irradiated with low energy visible light with or without molecular oxygen.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: November 8, 2005
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Karen Brewer, Shawn Swavey