Patents Examined by Lisa Bennett
-
Patent number: 5563256Abstract: Unique species-specific Eimeria tenella DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria tenella.Type: GrantFiled: May 12, 1992Date of Patent: October 8, 1996Assignee: Merck & Co., Inc.Inventors: Prasanta R. Chakraborty, Michael Dashkevicz, Alex Elbrecht, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
-
Patent number: 5449768Abstract: Unique species-specific Eimeria praecox DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria praecox.Type: GrantFiled: May 12, 1992Date of Patent: September 12, 1995Assignee: Merck and Co., Inc.Inventors: Prasanta R. Chakraborty, Michael Dashkevicz, Alex Elbrecht, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
-
Patent number: 5359050Abstract: Unique species-specific Eimeria mitis DNA probes comprising divergent DNA sequences are disclosed. The probes ere complementary to a small subunit ribosomal RNA gene of Eimeria mitis.Type: GrantFiled: May 12, 1992Date of Patent: October 25, 1994Assignee: Merck and Co., Inc.Inventors: Prasanta R. Chakraborty, Alex Elbrecht, Michael Dashkevicz, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
-
Patent number: 5298613Abstract: Unique species-specific Eimeria acervulina DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria acervulina.Type: GrantFiled: May 12, 1992Date of Patent: March 29, 1994Assignee: Merck and Co., Inc.Inventors: Prasanta R. Chakraborty, Alex Elbrecht, Michael Dashkevicz, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
-
Patent number: 5288845Abstract: Unique species-specific Eimeria necatrix DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria necatrix.Type: GrantFiled: May 12, 1992Date of Patent: February 22, 1994Assignee: Merck and Co., Inc.Inventors: Prasanta R. Chakraborty, Michael Dashkevicz, Alex Elbrecht, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
-
Patent number: 5278298Abstract: Unique species-specific Eimeria brunetti DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria brunetti.Type: GrantFiled: May 12, 1992Date of Patent: January 11, 1994Assignee: Merck & Co., Inc.Inventors: Prasanta R. Chakraborty, Alex Elbrecht, Michael Dashkevicz, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
-
Patent number: 5266689Abstract: Unique species-specific Eimeria maxima DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria maxima.Type: GrantFiled: May 12, 1992Date of Patent: November 30, 1993Assignee: Merck and Co., Inc.Inventors: Prasanta R. Chakraborty, Michael Dashkevicz, Alex Elbrecht, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
-
Patent number: 5264558Abstract: Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.Type: GrantFiled: March 30, 1990Date of Patent: November 23, 1993Assignees: The Regents of the University of California, Lucky Biotech CorporationInventors: Sung-Hou Kim, Joong M. Cho
-
Patent number: 5236844Abstract: The present invention relates to a gene encoding a new member of the metalloproteinase family which has been found to be specifically associated with invasive breast cancer, and to methods of diagnosis for such cancer comprising detection of the marker or its nucleotide sequence, and to treatment or prophylaxis by inhibiting, altering the activity of or binding the marker, or by interfering with its synthesis.Type: GrantFiled: November 21, 1991Date of Patent: August 17, 1993Assignees: Institut National de la Sante et de la Recherche Medicale, Centre National de Recherche Scientifique, Universite Louis Pasteur StrasbourgInventors: Paul Basset, Jean-Pierre Bellocq, Pierre Chambon
-
Patent number: 5215881Abstract: Regions in the pseudorabies virus genome in the unique long region and the internal repeat sequence contain nucleotide sequences which are unique to latent infection of the virus. These regions are the basis for constructing nucleic acid probes and antigens useful in distinguishing latent pseudorabies infection from productive infection.Type: GrantFiled: June 13, 1990Date of Patent: June 1, 1993Assignee: The United States of America as represented by the Secretary of AgricultureInventor: Andrew K. Cheung
-
Patent number: 5215898Abstract: A novel cytotoxic protein is described possessing antifungal activity and which may be used for the treatment of fungal infections, or the prevention or control of fungal growth, as well as being potentially valuable as a biopesticide such as an insecticide, nematicide, or herbicide. The protein is produced by culture of Pichia inositovora strain NRRL Y-18709, and may be subsequently recovered from the culture medium and purified.Type: GrantFiled: July 22, 1991Date of Patent: June 1, 1993Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Paul L. Bolen, G. Thomas Hayman
-
Patent number: 5204238Abstract: The present invention provides a process for the reduction of non-specific star activities in the case of the specific cleavage of desoxyribonucleic acids by incubation with a restriction endonuclease in an appropriate buffer, wherein to the incubation batch is added an antibiotic which binds to the DNA on or near the star sequences of the enzyme but not within the specific recognition sequence of the restriction endonuclease.Type: GrantFiled: March 14, 1991Date of Patent: April 20, 1993Assignee: Boehringer Mannheim GmbHInventors: Frank Laue, Waltraud Ankenbauer, Gudrun Schmitz
-
Patent number: 5185242Abstract: The invention provides a rapid method for lysing Mycobacteria. In one embodiment is provided a method for lysing Mycobacteria which comprises exposing the bacteria to a lysis effective amount of the enzyme achromopeptidase.The method of the invention is particularly advantageous since only one step is involved, it is expedient compared to prior methods, and little instrumentation is necessary. By practicing the present invention it is possible to lyse Mycobacteria with minimal effort. In addition, practicing the invention results in liberating cellular components including deoxyribonucleic acid (DNA) from Mycobacteria. Not only is DNA liberated, but the DNA is suited for subsequent analysis by way of probe hybridization, restriction enzyme analysis, and the like.Type: GrantFiled: June 24, 1991Date of Patent: February 9, 1993Assignee: Becton Dickinson and CompanyInventors: William E. Keating, Jillian A. Robson