Patents Examined by Lisa Bennett
  • Patent number: 5563256
    Abstract: Unique species-specific Eimeria tenella DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria tenella.
    Type: Grant
    Filed: May 12, 1992
    Date of Patent: October 8, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Prasanta R. Chakraborty, Michael Dashkevicz, Alex Elbrecht, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
  • Patent number: 5449768
    Abstract: Unique species-specific Eimeria praecox DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria praecox.
    Type: Grant
    Filed: May 12, 1992
    Date of Patent: September 12, 1995
    Assignee: Merck and Co., Inc.
    Inventors: Prasanta R. Chakraborty, Michael Dashkevicz, Alex Elbrecht, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
  • Patent number: 5359050
    Abstract: Unique species-specific Eimeria mitis DNA probes comprising divergent DNA sequences are disclosed. The probes ere complementary to a small subunit ribosomal RNA gene of Eimeria mitis.
    Type: Grant
    Filed: May 12, 1992
    Date of Patent: October 25, 1994
    Assignee: Merck and Co., Inc.
    Inventors: Prasanta R. Chakraborty, Alex Elbrecht, Michael Dashkevicz, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
  • Patent number: 5298613
    Abstract: Unique species-specific Eimeria acervulina DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria acervulina.
    Type: Grant
    Filed: May 12, 1992
    Date of Patent: March 29, 1994
    Assignee: Merck and Co., Inc.
    Inventors: Prasanta R. Chakraborty, Alex Elbrecht, Michael Dashkevicz, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
  • Patent number: 5288845
    Abstract: Unique species-specific Eimeria necatrix DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria necatrix.
    Type: Grant
    Filed: May 12, 1992
    Date of Patent: February 22, 1994
    Assignee: Merck and Co., Inc.
    Inventors: Prasanta R. Chakraborty, Michael Dashkevicz, Alex Elbrecht, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
  • Patent number: 5278298
    Abstract: Unique species-specific Eimeria brunetti DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria brunetti.
    Type: Grant
    Filed: May 12, 1992
    Date of Patent: January 11, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Prasanta R. Chakraborty, Alex Elbrecht, Michael Dashkevicz, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
  • Patent number: 5266689
    Abstract: Unique species-specific Eimeria maxima DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria maxima.
    Type: Grant
    Filed: May 12, 1992
    Date of Patent: November 30, 1993
    Assignee: Merck and Co., Inc.
    Inventors: Prasanta R. Chakraborty, Michael Dashkevicz, Alex Elbrecht, Scott D. Feighner, Paul A. Liberator, Helen Profous-Juchelka
  • Patent number: 5264558
    Abstract: Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: November 23, 1993
    Assignees: The Regents of the University of California, Lucky Biotech Corporation
    Inventors: Sung-Hou Kim, Joong M. Cho
  • Patent number: 5236844
    Abstract: The present invention relates to a gene encoding a new member of the metalloproteinase family which has been found to be specifically associated with invasive breast cancer, and to methods of diagnosis for such cancer comprising detection of the marker or its nucleotide sequence, and to treatment or prophylaxis by inhibiting, altering the activity of or binding the marker, or by interfering with its synthesis.
    Type: Grant
    Filed: November 21, 1991
    Date of Patent: August 17, 1993
    Assignees: Institut National de la Sante et de la Recherche Medicale, Centre National de Recherche Scientifique, Universite Louis Pasteur Strasbourg
    Inventors: Paul Basset, Jean-Pierre Bellocq, Pierre Chambon
  • Patent number: 5215881
    Abstract: Regions in the pseudorabies virus genome in the unique long region and the internal repeat sequence contain nucleotide sequences which are unique to latent infection of the virus. These regions are the basis for constructing nucleic acid probes and antigens useful in distinguishing latent pseudorabies infection from productive infection.
    Type: Grant
    Filed: June 13, 1990
    Date of Patent: June 1, 1993
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventor: Andrew K. Cheung
  • Patent number: 5215898
    Abstract: A novel cytotoxic protein is described possessing antifungal activity and which may be used for the treatment of fungal infections, or the prevention or control of fungal growth, as well as being potentially valuable as a biopesticide such as an insecticide, nematicide, or herbicide. The protein is produced by culture of Pichia inositovora strain NRRL Y-18709, and may be subsequently recovered from the culture medium and purified.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: June 1, 1993
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Paul L. Bolen, G. Thomas Hayman
  • Patent number: 5204238
    Abstract: The present invention provides a process for the reduction of non-specific star activities in the case of the specific cleavage of desoxyribonucleic acids by incubation with a restriction endonuclease in an appropriate buffer, wherein to the incubation batch is added an antibiotic which binds to the DNA on or near the star sequences of the enzyme but not within the specific recognition sequence of the restriction endonuclease.
    Type: Grant
    Filed: March 14, 1991
    Date of Patent: April 20, 1993
    Assignee: Boehringer Mannheim GmbH
    Inventors: Frank Laue, Waltraud Ankenbauer, Gudrun Schmitz
  • Patent number: 5185242
    Abstract: The invention provides a rapid method for lysing Mycobacteria. In one embodiment is provided a method for lysing Mycobacteria which comprises exposing the bacteria to a lysis effective amount of the enzyme achromopeptidase.The method of the invention is particularly advantageous since only one step is involved, it is expedient compared to prior methods, and little instrumentation is necessary. By practicing the present invention it is possible to lyse Mycobacteria with minimal effort. In addition, practicing the invention results in liberating cellular components including deoxyribonucleic acid (DNA) from Mycobacteria. Not only is DNA liberated, but the DNA is suited for subsequent analysis by way of probe hybridization, restriction enzyme analysis, and the like.
    Type: Grant
    Filed: June 24, 1991
    Date of Patent: February 9, 1993
    Assignee: Becton Dickinson and Company
    Inventors: William E. Keating, Jillian A. Robson