Patents Examined by Lisa Hobbs
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Patent number: 9453842Abstract: The present invention deals with reagents and compositions capable of effectively inhibiting peroxidase activity. According to the invention, peroxidase enzymatic activity is blocked with an acidic aqueous solution of a protein denaturing agent. Preferred protein denaturing agents are detergents and chaotropic substances.Type: GrantFiled: April 9, 2014Date of Patent: September 27, 2016Assignee: Roche Molecular Systems, Inc.Inventors: Manfred Watzele, Bernd Buchberger, Claudia Kirr
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Patent number: 7998699Abstract: The present invention is a method of extracting infectious pathogens from a volume of blood including the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The fibrin lysis reagent is preferably composed of plasminogen and streptokinase frozen in coincident relation until the fibrin lysis reagent is needed whereby streptokinase enzymatically reacts with plasminogen to form plasmin upon thawing. The plasminogen is suspended in an aqueous salt solution prior to freezing including NaCl and Na3PO4.Type: GrantFiled: August 15, 2003Date of Patent: August 16, 2011Assignee: University of South FloridaInventors: Matt Ewert, Philip Amuso, Andrew Cannons
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Patent number: 7993870Abstract: The present invention is a method of extracting infectious pathogens from a volume of blood including the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The fibrin lysis reagent is preferably composed of plasminogen and streptokinase frozen in coincident relation until the fibrin lysis reagent is needed whereby streptokinase enzymatically reacts with plasminogen to form plasmin upon thawing. The plasminogen is suspended in an aqueous salt solution prior to freezing including NaCl and Na3PO4.Type: GrantFiled: April 1, 2009Date of Patent: August 9, 2011Assignee: University of South FloridaInventors: Matt Ewert, Philip Amuso, Andrew Cannons
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Patent number: 6245540Abstract: Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.Type: GrantFiled: June 5, 1995Date of Patent: June 12, 2001Assignee: Human Genome Sciences, Inc.Inventors: Peter J. Hudson, Wei Wu He, Craig A. Rosen, Jeannine D. Gocayne
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Patent number: 6100085Abstract: The present invention relates to novel mammalian amino acid transporter proteins and the genes that encode such proteins. The invention is directed toward the isolation, characterization and pharmacological use of the human amino acid transporter proteins EAAT1, EAAT2, EAAT3 and ASCT1. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to each of these transporter genes. Also provided are recombinant expression constructs capable of expressing each of the amino acid transporter genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the human amino acid transporter proteins encoded therein. The invention also provides methods for screening in vitro compounds having transport-modulating properties using preparations of transporter proteins from such cultures of cells transformed with recombinant expression constructs.Type: GrantFiled: March 17, 1998Date of Patent: August 8, 2000Assignee: Oregon Health Sciences UniversityInventors: Susan G. Amara, Jeffrey L. Arriza
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Patent number: 6090600Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.Type: GrantFiled: December 23, 1997Date of Patent: July 18, 2000Assignee: SmithKline Beecham plcInventors: John Edward Hodgson, Elizabeth Jane Lawlor
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Patent number: 6074828Abstract: The present invention relates to novel mammalian amino acid transporter proteins and the genes that encode such proteins. The invention is directed toward the isolation, characterization and pharmacological use of the human amino acid transporter proteins EAAT1, EAAT2, EAAT3 and ASCT1. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to each of these transporter genes. Also provided are recombinant expression constructs capable of expressing each of the amino acid transporter genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the human amino acid transporter proteins encoded therein. The invention also provides methods for screening in vitro compounds having transport-modulating properties using preparations of transporter proteins from such cultures of cells transformed with recombinant expression constructs.Type: GrantFiled: March 17, 1998Date of Patent: June 13, 2000Assignee: Oregon Health Sciences UniversityInventors: Susan G. Amara, Jeffrey L. Arriza
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Patent number: 6033893Abstract: The invention provides a new human cathepsin (LCAP) and polynucleotides which identify and encode LCAP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of LCAP.Type: GrantFiled: June 26, 1997Date of Patent: March 7, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Olga Bandman, Karl J. Guegler, Neil C. Corley, Purvi Shah
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Patent number: 6008041Abstract: The present invention provides the cDNA sequence encoding bovine dipeptidylaminopeptidase 1. The invention demonstrates that bovine DAP 1 coded by a single cDNA. The mature protein is derived from a single polypeptide consisting of a signal peptide, and a major polypeptide which is processed to generate the a subunit, b subunit and g subunit.Type: GrantFiled: May 2, 1997Date of Patent: December 28, 1999Assignee: Eli Lilly and CompanyInventors: Christopher Carl Frye, Charles Lee Hershberger, Haichao Zhang
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Patent number: 5994111Abstract: The invention provides novel tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.Type: GrantFiled: December 23, 1997Date of Patent: November 30, 1999Assignee: SmithKline Beecham plcInventors: John Edward Hodgson, Elizabeth Jane Lawlor
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Patent number: 5968747Abstract: The invention provides a human ubiquitin-like conjugating protein (UBCLE) and polynucleotides which identify and encode UBCLE. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of UBCLE.Type: GrantFiled: December 12, 1997Date of Patent: October 19, 1999Assignee: Incyte Pharmaceuticals, Inc.Inventors: Jennifer L. Hillman, Purvi Shah, Neil C. Corley
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Patent number: 5968761Abstract: The present invention relates to drug screening assays which provide a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of a cell-cycle regulatory protein, such as p53, p27, myc, fos, MAT.alpha.2, or cyclins. The invention further relates to novel ubiquitin-conjugating enzymes, and uses related thereto.Type: GrantFiled: June 7, 1995Date of Patent: October 19, 1999Assignee: Mitotix, Inc.Inventors: Mark Rolfe, Maria Isabel Chiu, Guillaume Cottarel, Vivian Berlin, Veronique Damagnez, Giulio Draetta
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Patent number: 5968797Abstract: Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptide for the treatment of the proliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.Type: GrantFiled: July 22, 1997Date of Patent: October 19, 1999Assignee: Human Genome Sciences, Inc.Inventors: Jian Ni, Reiner Gentz, Mark D. Adams
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Patent number: 5965416Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.Type: GrantFiled: December 23, 1997Date of Patent: October 12, 1999Assignee: SmithKline Beecham plcInventors: John Edward Hodgson, Elizabeth Jane Lawlor
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Patent number: 5955338Abstract: The invention provides a human phosphatidylinositol 4,5-bisphosphate 5-phosphatase (PBPP) and polynucleotides which identify and encode PBPP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PBPP.Type: GrantFiled: June 27, 1997Date of Patent: September 21, 1999Assignee: Incyte Pharmaceuticals, Inc.Inventors: Jennifer L. Hillman, Preeti Lal, Neil C. Corley, Purvi Shah
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Patent number: 5948657Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly baterial infections.Type: GrantFiled: September 16, 1997Date of Patent: September 7, 1999Assignee: SmithKline Beecham plcInventors: John Edward Hodgson, Elizabeth Jane Lawlor
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Patent number: 5948672Abstract: A cellulase preparation consisting essentially of a homogeneous endoglucanase component which is immunoreactive with an antibody raised against a highly purified .about.43 kD endoglucanase derived from Humicola insolens, DSM 1800, or which is homogeneous to said .about.43 kD endoglucanase, may be employed in the treatment cellulose-containing fabrics for harshness reduction or color clarification or to provide a localized variation in the color of such fabrics, or it may be employed in the treatment of paper pulp.Type: GrantFiled: February 14, 1995Date of Patent: September 7, 1999Assignee: Novo Nordisk A/SInventors: Grethe Rasmussen, Jan M.o slashed.ller Mikkelsen, Martin Schulein, Shamkant Anant Patkar, Fred Hagen, Carsten Mailand Hjort, Sven Hastrup
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Patent number: 5945322Abstract: The present invention is directed to nucleic acids encoding glycosyltransferases, the proteins encoded thereby, and to methods for synthesizing oligosaccharides using the glycosyltransferases of the invention. In particular, the present application is directed to identification a glycosyltransferase locus of Neisseria gonorrhoeae containing five open reading frames for five different glycosyltransferases. The functionally active glycosyltransferases of the invention are characterized by catalyzing reactions such as adding Gal .beta.1.fwdarw.4 to GlcNAc or Glc; adding GalNAc or GlcNAc .beta.1.fwdarw.3 to Gal; and adding Gal .alpha.1.fwdarw.4 to Gal. The glycosyltransferases of the invention are particularly suited to the synthesis of the oligosaccharides Gal.beta.1.fwdarw.4GlcNAc.beta.1.fwdarw.3Gal.beta.1.fwdarw.4Glc (a mimic of lacto-N-neotetraose), GalNAc.beta.1.fwdarw.3Gal.beta.1.fwdarw.4GlcNAc.beta.1.fwdarw.3Gal.beta.l. fwdarw.4Glc.beta.1.fwdarw.4 (a mimic ganglioside), and Gal.alpha.1.fwdarw.4Gal.beta.1.Type: GrantFiled: June 18, 1997Date of Patent: August 31, 1999Assignee: The Rockefeller UniversityInventor: Emil C. Gotschlich
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Patent number: 5939298Abstract: The invention provides pheS polypeptides and DNA (RNA) encoding pheS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pheS polypeptides to screen for antibacterial compounds.Type: GrantFiled: July 23, 1997Date of Patent: August 17, 1999Assignee: SmithKline Beecham CorporationInventors: James R Brown, Elizabeth J Lawlor, Raymond W Reichard
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Patent number: 5939305Abstract: The present invention relates to a gene encoding an ascomycete or deuteromycete carboxypeptidase Y gene, and host cells modified so as to produce reduced amounts of carboxypeptidase.Type: GrantFiled: November 10, 1997Date of Patent: August 17, 1999Assignee: Novo Nordisk Biotech IncInventors: Debbie Sue Yaver, Sheryl Ann Thompson