Patents Examined by Lisa Jones
  • 3,5-Dinitro oxanilic acid ester compounds, compositions and methods
    Patent number: 4172147
    Abstract: Novel compounds of the formula ##STR1## wherein R is alkyl of one to eight carbon atoms, inclusive, are formulated into pharmaceutical compositions suitable for oral or parenteral administration which are used as agents to prophylactically inhibit the allergic manifestations of a sensitized mammal.
    Type: Grant
    Filed: November 17, 1976
    Date of Patent: October 23, 1979
    Assignee: The Upjohn Company
    Inventors: Charles M. Hall, John B. Wright
  • Herbicidal sulfonamides
    Patent number: 4169719
    Abstract: N-(heterocyclicaminocarbonyl)arylsulfonamides, such as N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl] benzenesulfonamide, are useful for the regulation of plant growth and as herbicides, particularly for controlling nutsedge.
    Type: Grant
    Filed: October 6, 1977
    Date of Patent: October 2, 1979
    Assignee: E. I. Du Pont de Nemours and Co.
    Inventor: George Levitt
  • Isothiazolidin-3-ones
    Patent number: 4169949
    Abstract: Isothiazolidin-3-ones of the formula ##STR1## wherein R.sup.1 is a hydrogen atom, or an alkyl, cycloalkyl, aryl, aralkyl, carbamoyl, or thiocarbamoyl group,R.sup.2 and R.sup.3 are halogen atoms or alkyl groups, andX is a halogen atom and compositions containing them are useful in controlling microorganisms, such as bacteria, fungi, algae, and the like.
    Type: Grant
    Filed: June 9, 1977
    Date of Patent: October 2, 1979
    Assignee: Rohm and Haas Company
    Inventor: Ernest D. Weiler
  • 2-Amino propanol isothiozol-3-ones
    Patent number: 4169835
    Abstract: Novel isothiazoles having a 3-amino-2-OR-propoxy or - propyl substituent are disclosed. The isothiazoles have pharmaceutical activity.
    Type: Grant
    Filed: March 6, 1978
    Date of Patent: October 2, 1979
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Amino derivatives of 4-hydroxy-1,2-benzisothiazole
    Patent number: 4168317
    Abstract: New aminopropanol derivatives of 4-hydroxy-1,2-benzisothiazole and their addition salts with acids, their preparation, and pharmaceutical formulations which contain the said compounds and may be used for the treatment and prophylaxis of cardiac and circulatory disorders.
    Type: Grant
    Filed: January 30, 1978
    Date of Patent: September 18, 1979
    Assignee: BASF Aktiengesellschaft
    Inventors: Fritz-Frieder Frickel, Helmut Hagen, Ulrich Ohnsorge, Albrecht Franke, Dieter Lenke, Josef Gries, Hans D. Lehmann
  • 3-Alkoxyisothiazoles
    Patent number: 4167575
    Abstract: Disclosed are certain novel 3-alkoxyisothiazoles. The 3-alkoxyisothiazoles and compositions containing them exhibit useful biocidal properties.
    Type: Grant
    Filed: July 26, 1977
    Date of Patent: September 11, 1979
    Assignee: Rohm and Haas Company
    Inventors: George A. Miller, Sheldon N. Lewis
  • N-Hetero substituted cyclobutenones
    Patent number: 4166857
    Abstract: The compounds are 1-amino-2-heterocyclic-alkylamino-cyclobut-1-ene-3,4-diones which are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: July 27, 1978
    Date of Patent: September 4, 1979
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Charon R. Ganellin, Rodney C. Young
  • 3-Amino-N-[(phosphonoamino)iminomethyl]-6-halopyrazinecarboxamide compounds, compositions and methods of use
    Patent number: 4163781
    Abstract: The case involves novel 3-amino-N-[(phosphonoamino)iminomethyl]-6-halopyrazinecarboxamides, derivatives thereof and processes for preparing same. 3-Amino-N-(phosphonoaminoiminomethyl)-6-halopyrazinecarboxamides of the instant case are eukalemic agents possessing diuretic and natriuretic properties.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: August 7, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Otto W. Woltersdorf, Jr.
  • Benzothiazepine compounds and compositions
    Patent number: 4163785
    Abstract: The invention relates to 5-piperazinyl pyrido-[2,3-b][1,5] benzothiazepines of Formula I ##STR1## in which R is a hydrogen atom or a C.sub.1-5 alkyl group and their non-toxic acid addition salts. These compounds have antihistamine and antianaphylaxic activity. The invention also relates to a method of preparing these compounds.
    Type: Grant
    Filed: April 3, 1978
    Date of Patent: August 7, 1979
    Assignee: Hexachimie
    Inventors: Charles Hoffmann, Etienne Bouley
  • 1,2,3-Thiadiazole-5-yl-urea derivatives, process for making the same and plant retardation and defoliation composition containing same
    Patent number: 4163658
    Abstract: 1,2,3-Thiadiazole-5-yl-urea derivatives of the formula ##STR1## in which R.sub.1 is hydrogen or alkyl of 1 to 5 carbon atoms, R.sub.2 is hydrogen or alkyl from 1 to 5 carbon atoms which latter may also have at least one oxygen or sulfur atom interposed in the carbon chain and wherein R.sub.3 is a heterocyclic hydrocarbon residue in which at least one nitrogen atom is present in the ring, which residue may also be substituted by the same or different substituents comprising alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, nitro or trifluoromethyl. The compounds are effective as agents for growth retardation and defoliation of plants.The invention also comprises a process of making the product and compositions in which the products are the, or one of the, effective agents.
    Type: Grant
    Filed: August 16, 1978
    Date of Patent: August 7, 1979
    Assignee: Schering Aktiengesellschaft
    Inventors: Friedrich Arndt, Hans-Rudolf Kruger, Reinhart Rusch
  • Imidazo[1,5-a]-quinolinium and imidazo[1,5-a]-pyridinium compounds
    Patent number: 4163745
    Abstract: The synthesis of imidazo[1,2-a]pyridinium, imidazo[1,5-a]pyridinium, pyrrolo[1,2-a]pyrazinium, pyrazolo[1,5-a]pyridinium, imidazo[2,1-a]isoquinolinium and imidazo[5,1-a]isoquinolinium quaternary salts and their use as hypoglycemic agents.
    Type: Grant
    Filed: August 8, 1977
    Date of Patent: August 7, 1979
    Assignee: Pfizer Inc.
    Inventor: Donald E. Kuhla
  • Phenoxy phenyl pyrrolidine compounds, compositions and methods of use
    Patent number: 4161529
    Abstract: Pyrrolidone derivatives of the formula: ##STR1## wherein R is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl,AndY is hydrogen, saturated or unsaturated hydrocarbon radical up to C.sub.4, hydroxyethyl, hydroxypropyl or carboxymethyl.These compounds are used as medicines especially in the treatment of lipid-metabolism disorders.
    Type: Grant
    Filed: February 14, 1978
    Date of Patent: July 17, 1979
    Assignee: Science Union et Cie, Societe Francaise de Recherche Medicale
    Inventors: Laszlo Beregi, Pierre Hugon, Jacques Duhault, Michelle Boulanger
  • Oxamic acid derivatives
    Patent number: 4160100
    Abstract: Anti-allergic agents of aromatic and heterocyclic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 2-pyridyl-N-oxide, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, .alpha.-naphthyl, .beta.
    Type: Grant
    Filed: March 23, 1976
    Date of Patent: July 3, 1979
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Charles J. Guinosso, Albert J. Begany
  • 4-Pyrimidones compositions, and methods of use
    Patent number: 4159329
    Abstract: The compounds are substituted isocytosines which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are 2-[2-(5-methyl-4-imidazolylmethylthio)-ethylamino]-5-(3-methoxybenzyl)-4-p yrimidone and 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-6-benzyloxy-4-pyrimidone .
    Type: Grant
    Filed: December 15, 1977
    Date of Patent: June 26, 1979
    Assignee: SmithKline & French Laboratories Limited
    Inventors: Thomas H. Brown, Graham J. Durant, John C. Emmett, Charon R. Ganellin
  • 10-(Piperazinyl)thieno[3,4-b][1,5]benzoxazepines and 10-(piperazinyl)thieno[3,4-b][1,5]benzothiazepines
    Patent number: 4157444
    Abstract: This disclosure describes 10-[4-(substituted)-1-piperazinyl]thieno[3,4-b][1,5]benzoxazepines and 10-[4-(substituted-1-piperazinyl]thieno[3,4-b][1,5]benzothiazepines useful as anti-psychotic or neuroleptic agents.
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: June 5, 1979
    Assignee: American Cyanamid Company
    Inventors: Jeffery B. Press, Sidney R. Safir
  • Piperazine and piperidine enamines having an hydroxy group
    Patent number: 4156779
    Abstract: What is disclosed is the method of making a monoenamine having a free hydroxy group which comprises reacting a lactone or a carboxylic acid containing an hydroxy group with an amine selected from the group consisting of 2-methyl piperazine, 1-(2-aminoethyl)-piperazine, 4-aminomethyl-piperidine, or 2,3-dimethyl-3-(gamma-aminopropyl)-piperidine to form the corresponding secondary amine containing an hydroxy group and then reacting said secondary amine with an aliphatic aldehyde or cyclic ketone to form said monoenamine.
    Type: Grant
    Filed: April 21, 1978
    Date of Patent: May 29, 1979
    Assignee: Schering Aktiengesellschaft
    Inventors: Christian Burba, Hans-Guenter Volland
  • Two phase process for the preparation of azole and azoline disulfides
    Patent number: 4155910
    Abstract: Azole and azoline disulfides useful as corrosion inhibitors and antiwear agents are prepared by the halogen-induced coupling of a thiol reactant e.g., hydrocarbyl mercaptans, with a metal azole thiolate, e.g. the potassium salt of 3,5-bis-mercapto 1,2,4-thiadiazole or 2,5-bis-mercapto 1,3,4 thiadiazole in a 2-phase reaction medium comprising a mixture of a hydrocarbon and water.
    Type: Grant
    Filed: February 23, 1977
    Date of Patent: May 22, 1979
    Assignee: Exxon Research & Engineering Co.
    Inventors: Stanley J. Brois, Antonio Gutierrez
  • Substituted isoxazolo compounds
    Patent number: 4154928
    Abstract: An improved process for the preparation of substituted isoxazolo[4,5-c]pyridin-4(5H)-ones which are either useful as intermediates in the preparation of compounds having pharmaceutical activity or as hypolipidemic agents which comprises cyclizing a corresponding 5-(2-amino-2-phenyl- or substituted phenyl-ethenyl)-3-substituted-N-alkyl isoxazole-4-carboxamide under acidic conditions.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: May 15, 1979
    Assignee: Sandoz, Inc.
    Inventors: Max Denzer, Joseph A. Smith
  • Substituted isocytosines having histamine H.sub.2 -antagonist activity
    Patent number: 4154834
    Abstract: The compounds are substituted isocytosines which are histamine H.sub.2 -antagonists. Two specific compounds of the present inventon are 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-py rimidone and 2-[2-(3-bromo-2-pyridylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-pyrimi done.
    Type: Grant
    Filed: December 16, 1977
    Date of Patent: May 15, 1979
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Graham J. Durant, Charon R. Ganellin
  • Substituted 2,3-dihydro imidazo[1,2-c]pyrimidines
    Patent number: 4153695
    Abstract: Di-substituted 2,3-dihydroimidazo[1,2-c]pyrimidines, useful as anti-viral agents.
    Type: Grant
    Filed: March 9, 1978
    Date of Patent: May 8, 1979
    Assignee: Eli Lilly and Company
    Inventor: William W. Turner