Patents Examined by Lisa V. Cook
  • Patent number: 10429391
    Abstract: The invention relates to a method for identifying specific marker proteins (biomarkers) for cholangiocellular carcinoma (CCC), the biomarkers for CCC identified by the method and the use thereof, in particular for diagnosis, surveillance and treatment. The invention further relates to a diagnostic device comprising the biomarkers for CCC and a screening assay wherein these biomarkers for CCC are used to identify novel pharmaceutical compounds for treatment of CCC.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: October 1, 2019
    Assignee: LEIBNIZ-INSTITUT FÜR ANALYTISCHE WISSENSCHAFTEN—ISAS—E.V.
    Inventors: Barbara Sitek, Helmut E. Meyer, Dominik Megger, Thilo Bracht, Juliet Padden, Hideo A. Baba, Jörg F. Schlaak, Frank Weber
  • Patent number: 10401367
    Abstract: A method of analyzing protein-protein interactions includes binding the first proteins to the substrate where the first proteins are tagged with the first markers which bind specifically to the biomolecules immobilized on the substrate or the first proteins bind specifically to the biomolecules immobilized on the substrate; incubating the substrate bound first proteins with cell lysate containing the second proteins which are tagged with second markers; analyzing the interactions between the first proteins and the second proteins in the cell lysate, and obtaining the first analytic value representing the kinetic picture of the interactions; incubating the substrate bound first proteins with cell lysate mixture of a cell lysate consisting of the second markers-tagged second proteins and another cell lysate comprising other proteins including unlabelled second proteins and obtaining the second analytic value; comparing and analyzing the first and the second analytic values.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: September 3, 2019
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventor: Tae-Young Yoon
  • Patent number: 10393735
    Abstract: The invention relates to a method and a processing device for the processing of a fluid containing interfering particles (C). Magnetic particles (MP) are added to the fluid in a processing chamber and distributed, in part, using a magnetic field to provide a blocking zone (BZ) within the processing chamber to impede or prevent such migration of the interfering particles (C) through the processing chamber. The blocking zone (BZ) hence acts as a filter element by which interfering particles (C) can for example be kept away from a detection region at the surface of the processing chamber.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: August 27, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Toon Hendrik Evers, Ron Martinus Laurentius Van Lieshout, Joannes Baptist Adrianus Dionisius Van Zon
  • Patent number: 10386275
    Abstract: A microscope slide staining system has a chamber, a plurality of slide support elements, a plurality of spreading devices positionable in association with microscope slides supported on the slide support elements so the spreading devices define a gap between the spreading device and the microscope slide and so the spreading device and the microscope slide are movable relative to one another to spread at least one reagent on the microscope slide independent of the other spreading devices and microscope slides.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: August 20, 2019
    Inventor: Lee H. Angros
  • Patent number: 10379122
    Abstract: Disclosed herein methods, compositions, and kits for obtaining a normalized measured amount of a target in a sample by measuring the amount of the target in the sample by contacting the sample with a detection reagent, measuring the amount of a ligand known to be absent in the sample being tested by contacting the sample with a control reagent, and obtaining the normalized measured amount of the target by calculating the ratio of the measured amount of the target to the measured amount of the ligand.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: August 13, 2019
    Inventors: Neal G. Satterly, Randal J. Schoepp
  • Patent number: 10359435
    Abstract: Methods, compositions, and kits for determining whether a subject has non-alcoholic fatty liver disease (NAFLD) are provided. Methods, compositions, and kits for determining whether a subject has non-alcoholic steatosis are also provided. Methods, compositions, and kits for determining whether a subject has non-alcoholic steatohepatitis (NASH) are also provided.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: July 23, 2019
    Assignee: SomaLogic, Inc.
    Inventors: Malti Nikrad, Stuart G. Field, Stephen Alaric Williams
  • Patent number: 10338081
    Abstract: The present invention provides biomarkers, methods and kits for diagnosing and prognosing the development of impaired glucose tolerance in a subject and the progression of diabetes in a subject, as well as methods for identifying a compound that can inhibit the development of impaired glucose tolerance and/or type 2 diabetes; reduce or slow down the progression of normal glucose tolerance to impaired fasting glycaemia, to impaired glucose tolerance, and/or to diabetes; and/or reduce or inhibit the development of complications associated with the disease in a subject, and methods for inhibiting the development of impaired glucose tolerance and/or type 2 diabetes; reducing or slowing down the progression of normal glucose tolerance to impaired fasting glycaemia, to impaired glucose tolerance, and/or to diabetes; and/or reducing or inhibiting the development of complications associated with the disease in a subject.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: July 2, 2019
    Assignees: Caprion Biosciences Inc., Adaerata, Limited Partnership, Val-Chum, Limited Partnership
    Inventors: Eustache Paramithiotis, Marc Prentki, Rèmi Rabasa-Lhoret, Pascal Croteau, Joel Lanoix, S.R. Murthy Madiraju, Èrik Joly
  • Patent number: 10295534
    Abstract: Provided is a method for measuring anti-drug antibodies ADAs appearing in a patient receiving molecular-targeted therapy in a simpler and more accurate manner.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: May 21, 2019
    Assignee: JIMRO CO., LTD.
    Inventors: Nobuhito Kashiwagi, Fumio Saitoh, Kenta Kaneda, Hidetaka Maegawa, Yuko Yagihashi
  • Patent number: 10288605
    Abstract: Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: May 14, 2019
    Assignee: Promega Corporation
    Inventors: Andrew S. Dixon, Lance Encell, Mary Hall, Keith Wood, Monika Wood, Marie Schwinn, Brock F. Binkowski, Hicham Zegzouti, Nidhi Nath, Subhanjan Mondal, Said Goueli, Poncho Meisenheimer, Thomas Kirkland, James Unch, Dileep K. Pulukkunat, Matthew Robers, Melanie Dart, Thomas Machleidt
  • Patent number: 10281476
    Abstract: Provided herein are methods for identifying a compound that modulates a Ryanodine receptor (Ryr). Fluorescence resonance energy transfer between an FKBP bound to an RyR and fluorescent derivatives of RyR binding partners (e.g., calmodulin) or domain-peptide biosensors is used to provide a readout dependent on the RyR functional state. The methods permit measurement of RyR present in a permeabilized cell or in a purified membrane.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: May 7, 2019
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Razvan L. Cornea, Donald M. Bers, David D. Thomas, Gregory D. Gillispie
  • Patent number: 10281376
    Abstract: An apparatus for spreading at least one reagent on at least a portion of a microscope slide includes a spreading device positionable in association with a microscope slide in a way that the spreading device defines a gap between the spreading device and the microscope slide and in a way that the spreading device and the microscope slide are movable relative to one another to spread at least one reagent on at least a portion of the microscope. The spreading device has a reservoir in which the at least one reagent is stored in a way that the at least one reagent is dischargeable from the reservoir onto the microscope slide when the spreading device is positioned in association with the microscope slide.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: May 7, 2019
    Inventor: Lee H. Angros
  • Patent number: 10274485
    Abstract: A method of detecting biomolecules present in a complex biological sample includes a) separating the biological sample into fractions according to at least one physical property of the biomolecules; and b) specifically detecting biomolecules present in the fractions using at least one solid-phase-based, immunological detection method including immobilizing the biomolecules from the individual fractions on microsphere populations specific for each fraction and distinguishable from one another.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: April 30, 2019
    Assignee: NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen
    Inventors: Markus Templin, Fridolin Treindl, Anette Doettinger, Oliver Poetz
  • Patent number: 10267809
    Abstract: Provided is a method of bioassay for the quantification of N- or C-terminal neo-epitope biomarkers formed by cleavage of a CRP, ApoE, lumican, versican, perlecan, decorin, biglycan or elastin by a proteinase. The method includes contacting a biofluid sample with an antibody reactive with the neo-epitope biomarker and determining the level of binding of the antibody to the biomarker in the sample. The assay is predictive of risk of cardiovascular disease events.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: April 23, 2019
    Assignee: Nordic Bioscience A/S
    Inventors: Morten Karsdal, Natasha Barascuk Michaelsen, Per Qvist
  • Patent number: 10267798
    Abstract: A method is provided for an in vitro detection of a first protein in a sample, including the steps of: a) separating the sample by a native separation method; b) transferring the separated sample onto a membrane; c) contacting the membrane with an aptamer which specifically binds to the first protein; and d) detecting the first protein by detecting the aptamer bound to the first protein.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: April 23, 2019
    Assignee: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Jens Kurreck, Anke Wagner, Viola Röhrs
  • Patent number: 10254276
    Abstract: An antibody composition, which is an aspect of the present invention, contains at least one compound selected from the group consisting of urea and urea derivatives, the compound being contained in the antibody composition at a concentration of not less than 0.1 M and less than 1 M, the antibody composition being a solution.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: April 9, 2019
    Assignee: RIKEN
    Inventors: Atsushi Miyawaki, Hiroshi Hama
  • Patent number: 10221453
    Abstract: The present invention relates to methods, monitors and systems, useful, for example, for advanced detection of sepsis in a subject.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: March 5, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Song Shi, Richard L. Moore, James Garrett
  • Patent number: 10215760
    Abstract: The present invention concerns the identification of biomarkers and groups or combinations of biomarkers that can be used for non-invasive diagnosis of intra-amniotic infection, and diagnostic assays using such biomarkers.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: February 26, 2019
    Assignee: Hologic, Inc.
    Inventor: Thomas H. Grove
  • Patent number: 10197559
    Abstract: The invention concerns a fusion polypeptide including several molecules of folding helper polypeptides, including one multimerization domain, in particular Skp, and at least one molecule of SlyD or SlpA, wherein no further target polypeptide sequences are fused to the fusion polypeptide. The invention further concerns an immunoassay and the use of the fusion polypeptide in an immunoassay for reduction of interferences or minimizing false positive results or for stabilizing proteinaceous assay reagents. Further the invention concerns a reagent kit for use in an immunoassay comprising the fusion polypeptide.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: February 5, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Hartmut Duefel, Alexander Riedel, Peter Schaarschmidt, Urban Schmitt, Christian Scholz
  • Patent number: 10197556
    Abstract: This disclosure relates to predicting the carcinogenicity of compounds. More in particular, this application discloses methods to detect whether a compound is a non-genotoxic carcinogen and methods to discriminate between genotoxic and non-genotoxic carcinogens based on in vivo stem cell proliferation patterns in flatworms.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: February 5, 2019
    Assignees: Universiteit Gent, Universiteit Hasselt
    Inventors: Karen Smeets, An-Sofie Stevens, Michelle Plusquin, Tom Artois, Maxime Willems, Jean Paul Remon
  • Patent number: 10191039
    Abstract: The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: January 29, 2019
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: David King, William F. Link, Renato del Rosario, Michael Leos