Abstract: The present disclosure is directed to methods and compositions for ameliorating, preventing and treating central nervous system (CNS) disorders. The invention aims to treat subjects suffering from, susceptible to, or diagnosed with CNS disorders, and in particular, to treating patients suffering from those disorders which are associated with neurotransmitter system dysfunction.

Abstract: The present invention provides methods of lyophilizing a pharmaceutical substance involving a primary drying step executed at a product temperature at or above the collapse temperature. The invention also provides pharmaceutical substances lyophilized at or above the collapse temperature.

Abstract: This invention relates to a granulate comprising mannitol and sorbitol in a weight ratio of between 70:30 and 97:3. This invention also relates to the use of a granulate in the preparation of orodispersible tablets, to the orodispersible tablets obtained with a granulate and to a process of for producing a granulate.

Abstract: A skin external preparation includes a finely dispersed wax composition that is solid or semisolid at room temperature, a nonionic surfactant, an aqueous dispersion medium, and an ionic water-soluble thickener, and optionally further contains at least one of silicone oil and fluorinated oil which is liquid at room temperature, and the mass ratio of the nonionic surfactant to the wax being 1.0 or more, the particle size of the finely dispersed wax is 500 nm or less, and it substantially contains no ionic surfactants therein.

Abstract: The present invention relates to a novel pharmaceutical composition free of gastric coating comprising anagrelide hydrochloride in combination with a non-pH dependent polymer and a pharmaceutically acceptable water soluble acid and its use for the treatment of essential thrombocythemia.

Abstract: A flowable, stable silica capsule formulation composed of a silica capsule suspension and an adjuvant for use in a personal care product, a beauty care product, a fabric care product, a home care product, a personal hygiene product, an oral care product is provided.

Abstract: The present invention relates to an emulsion concentrate containing water-insoluble oil components (A), hydrophilic non-ionic emulsifiers (B), lipophilic co-emulsifiers (C), polyols (D) and water; which comprises less than 50% by weight of water-insoluble oil component (A), based on the total weight of the concentrate, and comprises components (A), (B) and (C) and (D) in a ratio by weight A:B:C:D=1:(0.25-0.6):(0.25-0.6):(0.45-0.65). The invention further relates to the use of these emulsion concentrates, and also to preparations and paper products, non-woven products or textile products for body care and personal cleansing, which comprise water-insoluble oil components (A), hydrophilic non-ionic emulsifiers (B), lipophilic co-emulsifiers (C), and polyols (D) in a ratio by weight A:B:C:D=1:(0.25-0.6):(0.25-0.6):(0.45-0.65).

Abstract: A water-based pigmented preparation, its production and use and its application in a capillary storage system.

Abstract: Disclosed is the use of an insoluble or sparingly soluble micronized substance class which is not a cosmetic UV absorber and which is dispersed in the oil- or water-phase of a cosmetic or dermatological composition for the enhancement of light protecting action of this cosmetic or dermatological composition comprising at least one cosmetic UV filter which is soluble in the water- or oil-phase. The cosmetic preparation according to the invention shows a remarkable increase in SPF.

Abstract: A water-based pesticidal suspension comprises (a) flonicamid, (b) a polycarboxylate surfactant, (c) a sulfonate surfactant, and (d) water. The sulfonate surfactant (c) is at least one member selected from the group consisting of an alkyl sulfosuccinate, a lignosulfonate, a C8-18 alkyl benzene sulfonate and a C8-18 alkyl diphenyl ether disulfonate. An average particle size of the volume distribution of (a) flonicamid is preferably from 0.5 ?m to 10 ?m. The polycarboxylate surfactant (b) is preferably a sodium salt of maleic acid/olefin copolymer.

Abstract: The present invention is related to aqueous conditioning composition for hair comprising at least one cationic starch polymer and at least one additional cationic polymer selected from the ones with monosaccharide units. Conditioning composition of the present invention can be in the form of a shampoo, cleansing-conditioning composition, or in the form of a conditioner used after washing hair with cleansing compositions.

Abstract: A suspension which is suitable for oral administration, comprising simvastatin, at least one suspending agent, and at least one preservative, wherein at least 90 wt % of the particles of simvastatin are less than 100 ?m in diameter. The present invention also includes uses of the suspension and methods of making the suspension.

Abstract: The present invention provides a solid dosage form including an inner coating located between a core containing a pharmaceutically active ingredient and an outer enteric coating; wherein the inner coating includes a partially neutralized anionic polymeric material, and at least a carboxylic acid having 2 to 16 carbon atoms the salts thereof or mixtures of the acid and its salt; wherein the outer coating includes an anionic polymeric material which is less or not at all neutralized than the material of the inner coating.

Abstract: The present disclosure is directed to methods and compositions for ameliorating, preventing and treating central nervous system (CNS) disorders. The invention aims to treat subjects suffering from, susceptible to, or diagnosed with CNS disorders, and in particular, to treating patients suffering from those disorders which are associated with neurotransmitter system dysfunction.

Abstract: The invention relates to a thermoreversible oil-in-water emulsion comprising: a TLR4 agonist, the chemical structure of which does not comprise a sugar ring, squalene, a nonionic surfactant belonging to the polyoxyethylene alkyl ether chemical group, a hydrophilic surfactant, an aqueous solvent, and which shows immunostimulating properties.

Abstract: A production method for making powder cosmetics having improved characteristics. The method includes mixing a powder component and an oil component as a binder using a mixing apparatus. The mixing apparatus is a facing rotor type mixing apparatus having a first rotor with a plurality of blades and a second rotor with a plurality of blades in a mixing chamber. The first rotor and the second rotor face each other and have rotating shafts on the same axis line. In the facing rotor type mixing apparatus, raw materials are fed into an introduction opening on a first rotor side. The raw materials are mixed by rotating the first rotor and the second rotor in the same or opposite directions to each other, and the mixed raw materials are discharged from a discharge opening on a second rotor side.

Abstract: A solution in water comprising the following components at the following concentrations: (a) N×(70 to 130) g/L polyethylene glycol (PEG) having an average molecular weight of 2500 to 4500; (b) N×(1.6 to 4.0) g/L sodium chloride; (c) N×(0.2 to 0.6) g/L potassium chloride; (d) N×(0.6 to 2.2) g/L sodium bicarbonate; (e) N×an amount of preservative; (f) optionally N x an amount of flavouring; and (g) optionally N×an amount of sweetener, where N is in the range of 2 to 8. The solution is a concentrate for dilution. In use it is diluted N-fold with water to provide a solution for administration to a subject for the treatment of constipation or faecal impaction. Also provided are solutions, kits, unit doses and methods that comprise or use the solutions.

Abstract: The present invention is directed towards a composition comprising, in a cosmetically acceptable carrier, at least one silicone-organic polymer hybrid compound; at least one nonionic film forming polymer; at least one amphoteric film forming polymer; and a neutralizer. The present invention also relates to methods for imparting shape to or maintaining the shape of hair wherein the composition provides style memory, strong hold and good shine, while at the same time, providing smoothness and a natural feel to the hair.

Abstract: The invention presented in this application relates to a fragrance deposition system for high surfactant applications such as shampoo and body wash. The system will provide a long lasting release of the fragrance and is more efficient at low levels and does not deposit particles that can cause adverse properties.

Abstract: A method for inhibiting dentinal hypersensitivity by applying a dentinal hypersensitivity inhibitor on a dentin surface. The dentinal hypersensitivity inhibitor contains at least one tetracalcium phosphate particle, an alkali metal salt of phosphoric acid, and at least one acidic calcium phosphate particle. The tetracalcium phosphate particle has an average particle diameter of 0.5 to 40 ?m. The dentinal hypersensitivity inhibitor contains a blended amount of the tetracalcium phosphate particle of 5 to 55 parts by weight relative to 100 parts by weight of a whole amount of the dentinal hypersensitivity inhibitor and a blended amount of the alkali metal salt of phosphoric acid of 1 to 100 parts by weight relative to 100 parts by weight of the tetracalcium phosphate particle.