Abstract: A system for on-line psycho-physiological profiling and support implementing a personalization engine operating in a plurality of network systems. An implanted medical device (IMD) in data communication with the personalization engine provides physiological, therapy and diagnostic data pertinent to the patient. Based on one or a combination of explicit, implicit and transactional input from the patient and in consideration of the IMD data underlying therewith, the patient is guided to consult with the most pertinent database.