Patents Examined by Lori A. Clow
  • Patent number: 12039585
    Abstract: A computer implemented method for use in conjunction with a computing device, system, network, and cloud with touch screen two dimension display or augmented/mixed reality three dimension display comprising: obtaining, analyzing and detecting user blood and saliva chemistry data and mapping the blood and saliva data into a database associated with a specific user, applying the data with optimization equations and mapping equations to food chemistry such that a user may order food and beverage from a food/beverage distribution point or have food/beverage delivered to the user which has been specifically optimized for their specific blood characteristic target ranges. The method and system uses recursive techniques and neural networks to learn how to optimize food and beverage nutrient efficiency into the users blood chemistry.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: July 16, 2024
    Assignee: CIRCLESX LLC
    Inventors: Erik M Simpson, Gavin Simpson
  • Patent number: 12020782
    Abstract: The present disclosure generally relates to systems and methods for evaluating viability of oocytes. In some implementation examples, an image sequence associated with an oocyte being aspirated into a pressure tool is obtained. Based on the image sequence and pressures applied on the oocyte, morphological features and mechanical features associated with the oocyte can be derived. At least some of the features can then be fed into a machine learning model to determine metrics indicative of quality of the oocyte, where a particular metric may be indicative of blastocyst formation. Optionally, the determined oocyte quality information can be presented to a user via an interactive user interface.
    Type: Grant
    Filed: March 24, 2023
    Date of Patent: June 25, 2024
    Assignee: Inti Taiwan, Inc.
    Inventors: Wei-Ming Chen, I-Chiao Hsieh, Chung-Li Chiang
  • Patent number: 12014802
    Abstract: A device for locating a sample read with respect to a reference genome includes a plurality of groups of cells. Each group of cells stores a reference sequence representing reference bases from the reference genome corresponding to an order of cells in the respective group of cells. Each group of cells further stores a current substring sequence representing sample bases from the sample read corresponding to the order of the cells in the respective group of cells. Each group of cells stores the same current substring sequence and a reference sequence representing a portion of the reference genome that partially overlaps at least one other portion of the reference genome represented by one or more other reference sequences stored in one or more other groups of cells. Groups of cells are identified among the plurality of groups of cells where the stored reference sequence matches the current substring sequence.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: June 18, 2024
    Assignee: Western Digital Technologies, Inc.
    Inventor: Justin Kinney
  • Patent number: 12002545
    Abstract: During a feature-selection technique, an electronic device calculates combinations of features and noise vectors, where a given combination corresponds to a given feature and a given noise vector. Then, the electronic device determines statistical associations between information specifying types of events and the combinations, where a given statistical association corresponds to the types of events and a given combination. Moreover, the electronic device identifies a noise threshold associated with the combinations. Next, for a group of combinations having statistical associations equal to or greater than the noise threshold, the electronic device selects a subset of the features based at least in part on a first aggregate property of the group of combinations, where the first aggregate property comprises numbers of occurrences of the features in the group of combinations.
    Type: Grant
    Filed: February 17, 2018
    Date of Patent: June 4, 2024
    Assignee: Exsano, Inc.
    Inventor: Steven Elliot Stupp
  • Patent number: 11987620
    Abstract: Methods of treating a subject suffering from an autoimmune disease, disorder, or condition with an alternative to anti-TNF therapy.
    Type: Grant
    Filed: November 2, 2021
    Date of Patent: May 21, 2024
    Assignee: SCIPHER MEDICINE CORPORATION
    Inventors: Keith J. Johnson, Susan Ghiassian
  • Patent number: 11970696
    Abstract: An array-based system of assembled DNA for computer data storage is described. An array surface contains immobilized seed DNA initially having with blunt (or blocked) ends with a photocleavable optical linker at a forward end thereof holding the last few base pairs. A light source is light is applied to break the linker, generating a sticky end which allows for hybridization. Data-bearing DNA cassettes are introduced to the array and attach via their sticky ends to the unblock sites on the array surface. The attachment is made permanent via ligase.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: April 30, 2024
    Assignee: Leidos, Inc.
    Inventors: Steven Gerald Haupt, Stephen Alan Chappell
  • Patent number: 11965207
    Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: April 23, 2024
    Assignee: EUROFINS LIFECODEXX GMBH
    Inventors: Sebastian Grömminger, Wera Hofmann, Hamed Said, Matthias Sachse
  • Patent number: 11942188
    Abstract: Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: March 26, 2024
    Assignee: UCB Biopharma SRL
    Inventors: Jiye Shi, Terence Seward Baker, Alastair David Griffiths Lawson, Xiaofeng Liu
  • Patent number: 11929143
    Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for non-invasive assessment of copy number alterations. In particular, a method is provided for determining presence or absence of a copy number alteration for a test subject. The method includes providing a set of sequence reads. The sequence reads may be obtained from circulating cell free sample nucleic acid from a test sample obtained from the test subject, and the circulating cell free sample nucleic acid may be captured by probe oligonucleotides under hybridization conditions. The method further includes determining a probe coverage quantification of the sequence reads for the probe oligonucleotides and determining the presence or absence of a copy number alteration in the circulating cell free sample nucleic acid based on the probe coverage quantification of the sequence reads for the probe oligonucleotides for the test sample.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: March 12, 2024
    Assignee: SEQUENOM, INC
    Inventors: Yijin Wu, Amin Mazloom, Yang Zhong, Mostafa Azab
  • Patent number: 11906518
    Abstract: Methods described herein include receiving data from flowing a plurality of aptamers over a sample of tumor cells randomly affixed to a surface of a microfluidic device. The tumor cells may include one or more unknown tumor subtypes of cells. The plurality of aptamers may include a plurality of aptamer families. Each aptamer family of the plurality of aptamer families may be determined to bind to at least one possible subtype of the tumor cells. The data may include a measure of binding affinity of each aptamer family to the tumor cells. The method may include analyzing the measure of the binding affinity of each aptamer family to the tumor cells. The analyzing may include classifying the binding affinity. The method may also include determining one or more aptamer families that characterize the one or more unknown tumor subtypes of cells based on the classifying.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: February 20, 2024
    Assignee: X Development LLC
    Inventors: Ivan Grubisic, Ray Nagatani
  • Patent number: 11894106
    Abstract: Systems and methods for communicating, storing, and/or analyzing data that may include genomic data are described herein. In various embodiments, unaligned genomic sequence read data and/or portions thereof may be stored and/or communicated as a list of variants relative to a particular reference associated with a reference motif identified in the genomic sequence read data. In further embodiments, quality score information associated with a genomic dataset may be analyzed and/or communicated as quality score parameter information. Additional embodiments may facilitate relatively efficient analysis of unaligned genomic sequence read data using metadata associated with reference motifs identified in the unaligned genomic sequence read data.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: February 6, 2024
    Assignee: Intertrust Technologies Corporation
    Inventors: Jarl A. Nilsson, William Knox Carey
  • Patent number: 11875880
    Abstract: A method is disclosed for calculating and recalculating protein confidence values by recalculating peptide confidence values in proteomic analysis. A plurality of scans are performed of a sample that is proteolytically digested into surrogate peptide analytes. A plurality of spectra are obtained, and a plurality of peptides are identified. A protein database is searched for proteins matching peptides from the plurality of peptides. Peptide confidence values are determined for the set of peptides. A protein confidence value is calculated for each protein in the set of proteins. A protein from the set of proteins with a largest protein confidence value is selected, the largest protein confidence value for the protein is saved, the protein from the set of proteins is removed, and peptides corresponding to the protein is removed from the set of peptides. The protein confidence value is recalculated for each protein in the set of proteins.
    Type: Grant
    Filed: November 9, 2019
    Date of Patent: January 16, 2024
    Assignee: DH Technologies Development Pte Ltd.
    Inventor: Ignat V. Shilov
  • Patent number: 11871995
    Abstract: Systems, methods, and computer-readable media are disclosed for patient-specific modeling of hemodynamic parameters in coronary arteries. Example methods may include performing computational fluid dynamics simulations using a patient-specific coronary artery anatomical model derived from medical imaging data and patient-specific boundary conditions derived from a continuously recorded blood pressure waveform to determine patient-specific hemodynamic parameters in a patient's coronary arteries.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: January 16, 2024
    Assignee: Hemolens Diagnostics Sp. z o.o.
    Inventors: Andrzej Kosior, Kryspin Mirota, Wojciech Tarnawski
  • Patent number: 11861831
    Abstract: Systems and methods are disclosed for predicting the location, onset, or change of coronary lesions from factors like vessel geometry, physiology, and hemodynamics. One method includes: acquiring, for each of a plurality of individuals, a geometric model, blood flow characteristics, and plaque information for part of the individual's vascular system; training a machine learning algorithm based on the geometric models and blood flow characteristics for each of the plurality of individuals, and features predictive of the presence of plaque within the geometric models and blood flow characteristics of the plurality of individuals; acquiring, for a patient, a geometric model and blood flow characteristics for part of the patient's vascular system; and executing the machine learning algorithm on the patient's geometric model and blood flow characteristics to determine, based on the predictive features, plaque information of the patient for at least one point in the patient's geometric model.
    Type: Grant
    Filed: April 5, 2022
    Date of Patent: January 2, 2024
    Assignee: HeartFlow, Inc.
    Inventors: Gilwoo Choi, Leo Grady, Charles A. Taylor
  • Patent number: 11830580
    Abstract: A large collection of sample genomes containing misclassified k-mers and metadata errors from a reference taxonomy was converted to a self-consistent k-mer database comprising a self-consistent taxonomy. The self-consistent taxonomy was based on genetic distances calculated using the MinHash method or the Meier-Koltoff method. An agglomerative clustering algorithm was used to calculate the self-consistent taxonomy. Each k-mer of the sample genomes was assigned to only one node of the self-consistent taxonomy. In another step, each node of the self-consistent taxonomy was mapped to the reference taxonomy, thereby preserving in the self-consistent taxonomy links to the reference taxonomy while correcting for the misclassification errors therein. The self-consistent k-mer database can be used to taxonomically profile sequenced nucleic acids with greater specificity compared to systems relying on the reference taxonomy.
    Type: Grant
    Filed: September 30, 2018
    Date of Patent: November 28, 2023
    Assignees: International Business Machines Corporation, Mars, Incorporated
    Inventors: James H. Kaufman, Matthew A. Davis, Mark Kunitomi, Bart C. Weimer
  • Patent number: 11810651
    Abstract: Systems and methods for multi-dimensional mapping of binary data DNA sequences are described. In one embodiment, the method may include determining a current level of a first DNA base from a sequence of DNA bases based at least in part on a read process of the sequence, determining a current level of a second DNA base after the first DNA base and a current level of a third DNA base after the second DNA base, and decoding binary data from the sequence based at least in part on the determined current level of the first DNA base, the determined current level of the second DNA base, and/or the determined current level of the third DNA base.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: November 7, 2023
    Assignee: SEAGATE TECHNOLOGY LLC
    Inventor: Mehmet Fatih Erden
  • Patent number: 11773451
    Abstract: Provided herein are methods for determining the microsatellite instability status of samples. In one aspect, the methods include quantifying a number of different repeat lengths present at each of a plurality of microsatellite loci from sequence information to generate a site score for each of the plurality of the microsatellite loci. The methods also include comparing the site score of a given microsatellite locus to a site specific trained threshold for the given microsatellite locus for each of the plurality of the microsatellite loci and calling the given microsatellite locus as being unstable when the site score of the given microsatellite locus exceeds the site specific trained threshold for the given microsatellite locus to generate a microsatellite instability score, which includes a number of unstable microsatellite loci from the plurality of the microsatellite loci.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: October 3, 2023
    Assignee: Guardant Health, Inc.
    Inventors: Aliaksandr Artsiomenka, Marcin Sikora, Catalin Barbacioru, Darya Chudova, Martina I. Lefterova
  • Patent number: 11769596
    Abstract: The invention provides biomarkers and combinations of biomarkers useful in diagnosing non-small cell lung cancer. Measurements of these biomarkers are inputted into a classification system such as Random Forest to assist in determining the likelihood that an individual has non-small cell lung cancer. Kits comprising agents for detecting the biomarkers and combination of biomarkers, as well as systems that assist in diagnosing non-small cell lung cancer are also provided.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: September 26, 2023
    Assignee: LUNG CANCER PROTEOMICS LLC
    Inventors: Cherylle Goebel, Christopher Louden, Thomas C Long
  • Patent number: 11761023
    Abstract: Among other things, motility of at least one individual microorganism or a change in motility of at least one individual microorganism or both is or are characterized. The characterized motility or change in motility is used to detect the presence or count of the at least one individual microorganism, or determine the identity of a species or strain of the at least one individual microorganism, or determine a susceptibility of the at least one individual microorganism to one or more antibiotics or other antimicrobials.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: September 19, 2023
    Assignee: PHAST CORP.
    Inventors: Kwangmin Son, Roman Stocker
  • Patent number: 11746315
    Abstract: [PROBLEM] It is an object to provide a biological tissue fabrication information generating device that generates biological tissue fabrication information for fabrication of tissue imitative of the structure of the biological tissue of a patient, a biological tissue fabrication system that fabricates biological tissue based on biological tissue fabrication information, and a medical expense calculation system that calculates the medical expense of a patient receiving therapeutic graft of biological tissue.
    Type: Grant
    Filed: September 5, 2016
    Date of Patent: September 5, 2023
    Assignee: KANEKA CORPORATION
    Inventors: Hirokazu Akiyama, Masaki Ichimura, Hirotoshi Matsuta