Abstract: Aromatic urethanes can be produced in exceedingly improved yield when an aromatic nitro compound, an organic compound containing hydroxyl groups, and carbon monoxide are reacted in the presence of a catalyst composed of metallic (elemental) selenium or a selenium compound and a base serving as promoter, to which reaction system an aromatic amino compound and/or an aromatic urea compound which will be secondarily produced by the reaction has been previously added in order to suppress side reactions. For instance, when nitrobenzene, methanol and carbon monoxide are interacted in the presence of metallic selenium and triethylenediamine, the conversion of nitrobenzene is 68% and the percentage of formed methyl N-phenylcarbamate to the interacted nitrobenzene is 80%, whereas when the reaction is effected under the same reaction conditions indicated above with addition to the reaction system of aniline in an amount of about 15 wt.

Abstract: The disclosure relates to a novel chemical process whereby enone intermediates for prostaglandins are reduced steroselectively to the .alpha.-enols, the .alpha.-hydroxy of which corresponds to the prostaglandin 15.alpha.-hydroxy group.

Abstract: In the preparation of glycol esters by the oxidation of an olefin in the presence of a catalyst comprising tellurium, wherein the accumulation of foreign metals in association with the tellurium catalyst component has an adverse effect upon the reaction, such foreign metals are maintained at low levels while the tellurium catalyst values are recovered for recycling in high yield by purging a portion of a high-boiling residual fraction produced in the distillation treatment of the reaction mixture and treating the purged portion with water and/or an aqueous alkaline solution.

Abstract: Novel compounds of the formula ##STR1## wherein X is hydrogen, alkyl of one to six carbon atoms, inclusive, alkoxy of one to six atoms, inclusive, phenyl, cyano, nitro, trifluoromethyl, fluoro, chloro or bromo;R is hydrogen, alkyl of one to eight carbon atoms, inclusive, and a physiologically acceptable metal or amine cation and novel compositions wherein R is hydrogen or a physiologically acceptable metal or amine cation are used for prophylactically treating allergic disorders such as asthma.BRIEF SUMMARY OF THE INVENTIONIt has now been discovered that novel compounds of Formula I are useful in the prophylactic treatment of sensitized humans and animals for allergy and anaphylactic reactions of a reagin or non-reagin mediated nature. The compounds are formulated with pharmaceutical carriers for oral, parenteral, inhalation or rectal means of administration.

Abstract: Substituted 2-aminomethyl-4-phenyl-1,3-benzodioxans and derivatives thereof have been found to possess valuable anticonvulsant and antiarrhythmia activity in mammals. For example, cis-6-chloro-2-methylaminomethyl-4-phenyl-1,3-benzodioxan hydrochloride possesses potent anticonvulsant activity while cis-2-isopropylaminomethyl-4-phenyl-1,3-benzodioxan hydrochloride has potent antiarrhythmia activity.

Abstract: A process for the manufacture of ##STR1## where R and A are identical or different and each is alky of 1 to 4 carbon atoms, by oxidation of ##STR2## with air, oxygen or mixtures thereof, in an acid medium at a pH of from 1.5 to 5.5, at from 30.degree. to 150.degree. C. The reaction takes place rapidly and gives a good yield of the lactone (I), which can be freed from residual (II) by a treatment with alkali. The compound (I) is used as a dye intermediate in no-carbon copying systems.

Abstract: A process for preparing glycol esters such as ethylene glycol diacetate which comprises contacting a monoolefin such as ethylene with an organic monocarboxylic acid such as acetic acid containing a palladous salt and either a nitrate or a nitrite.

Abstract: New cyclopropanecarboxylates of the formula ##STR1## are disclosed, wherein R.sub.1 represents hydrogen, methyl or ethyl and n is 1, 2 or 3. These compounds are useful as pesticides, especially for the control of insects and pests of the order Acarina and cotton and vegetable plant pests.

Abstract: A method for the preparation of .beta.-amino derivatives of .alpha.,.beta.-unsaturated esters of the formula CH.sub.3 C(NH.sub.2)=CHCOOR' where R' is C.sub.1 to C.sub.10 linear or branched alkyl or substituted C.sub.1 to C.sub.10 linear or branched alkyl. A reaction mixture of an acetoacetate ester of the formula CH.sub.3 C(O)CH.sub.2 C(O)OR' wherein R' is the same as defined above is first formed in an organic solvent and this mixture reacted with aqueous ammonium hydroxide in the presence of a salt of ammonia or of a metal selected from the group consisting of lithium, zinc, cadmium, cerium and lead. The salt is soluble in the organic solvent to an extent sufficient to catalyze the reaction between ammonia and the ester.

Abstract: There is disclosed 4,10-dihydro-4,10-dioxo-1H-1-benzopyrano[3,2-b]pyridine-2-carboxylic acids, salts and esters of the formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; R.sub.2 is hydrogen, aralkyl or lower alkyl; R.sub.3 is hydrogen or lower alkyl and their pharmaceutically acceptable salts.These compounds are useful in the management of allergic conditions such as bronchial asthma, hay fever and so on.

Abstract: Certain novel carbamates of the formulas: ##STR1## where R.sub.1 is alkyl of 1-3 carbon atoms;R.sub.2 is alkyl of 1-4 carbon atoms; andX.sub.1 and X.sub.2 are independently selected from oxygen and sulfur;Are useful intermediates to react with aromatic and aliphatic amines to yield herbicidal allophanimidates.

Abstract: Described are certain spiro carboxylic acids and their allethrolone esters. The esters of these acids possess unique insecticidal properties and are useful as such in home, garden and agricultural applications.

Abstract: Vicinal hydroxyesters and diesters are prepared by the oxidation of olefins with molecular oxygen in a carboxylic acid at a temperature of over 150.degree. C. in the presence of a catalyst combination containing tellurium and an iodide source.

Abstract: The invention relates to substituted 5-(phenyl)benzoic acid esters and non-toxic pharmaceutically accepted salts thereof and processes for their preparation. The substituted 5-(phenyl)benozic acids are useful as anti-inflammatory compounds. Also included are method of treating inflammation claims by administering these particular compounds to patients.

Abstract: The compounds are benz[f]indazoles, e.g., 3-(p-chlorophenyl)-1-methylbenz[f]indazole, and are useful as fertility control agents.

Abstract: Preparation of tert-(cyclo)alkyl 1-hydrogen-2- hydrocarbylcyclopropanecarboxylates or 1-tert-(cyclo)alkyl spiro [2,p] alkanecarboxylates where p is an integer of at least 2 by reaction of a tert-(cyclo)alkyl 1-hydrogen-2-halocyclopropanecarboxylate with a (1) hydrocarbylmagnesium halide or (2) polymethylene-bis(magnesium halide)- or a magnesiacycloalkane, followed by addition of a proton donor to the reaction product thus obtained.

Abstract: A process for the production of succinylosuccinic acid diester. The process includes reacting a .gamma.-haloacetoacetic ester with a strong base. The reaction is conducted in the presence of at least one dispersing agent and an aqueous buffer solution of at least one inorganic salt at a pH of 8 to 10. The pH is kept constant during the reaction by the addition of a strong base as needed. The reaction is conducted at a temperature between -10.degree. and 10.degree. C. and preferably between -2.degree. and 0.degree. C. The succinylosuccinic acid diester can be isolated by any convenient method such as filtering or centrifuging it from the reaction solution.

Abstract: A process for the manufacture of butenediol diacetates, especially of but-2-ene-1,4-diol diacetate, by reaction of butadiene with oxygen and acetic acid, in the gas phase, over a solid catalyst which contains palladium and at least one element of main group 5 or 6.

Abstract: A polyurethane prepolymer composition comprising (1) not less than 0.65 by weight of the idealized adduct from trimethylolpropane with 3 moles of 3-isocyanatomethyl-3,5,5-trimethylcyclohexylisocyanate and (2) not more than 0.05 by weight of 3-isocyanatomethyl-3,5,5-trimethylcyclohexylisocyanate relative to the whole composition is very suitable for an isocyanate component of a two-package urethane coating and gives a coating film having excellent gloss, weathering resistance, adhesivity and impact resistance.

Abstract: A process for preparing 11-deoxyprostaglandin E.sub.1, E.sub.2 and E.sub.3 and analogs thereof is realized by treating an appropriate di(lower)alkyl 3-(optionally substituted)-2-formylcyclopropane-1,1-dicarboxylate with an ylid prepared from a Wittig reagent of formula (AlkO).sub.2 POCH.sub.2 CO-(c)-CH.sub.3 in which Alk is an alkyl containing one to three carbon atoms and (c) is either (CH.sub.2).sub.q wherein q is an integer from 1 to 6 or cis CH.sub.2 CH=CH(CH.sub.2).sub.r wherein r is an integer from 0 to 3 to obtain the corresponding compound of formula: ##STR1## in which R.sup.2 is hydrogen, lower alkyl or CH.sub.2 OR.sup.3 wherein R.sup.3 is lower alkanoyl, R.sup.4 is lower alkyl and (c) is as defined herein. The latter compound is reduced with an alkali metal borohydride to yield the corresponding alcohol derivative. Condensation of this alcohol derivative or preferably its corresponding tetrahydropyran-2-yl ether derivative with a triester of formula CH(COOR.sup.6).sub.2 --(a)-(CH.sub.