Abstract: Tetra-substituted ethylenes having the general formula ##EQU1## in which R is selected from the group consisting of alkyl radicals containing 1 to 4 carbon atoms and ##SPC1## AND A is selected from the group consisting of ##EQU2## and salts thereof with pharmacologically acceptable acids are useful as anti-inflammatory agents.

Abstract: A series of 5-endo-carbamoyloxy-N-[amino(lower)-alkyl]bicyclo[2.2.1]heptane-2,3-di-end o-carboxylic acid imides have been found to possess unique prophylactic and therapeutic activity as anti-arrhythmia agents. An example of such a compound possessing excellent activity is 5-endo-phenylcarbamoyloxy-N-(3-dimethylaminopropyl)bicyclo[2.2.1]heptane-2 ,3-diendo-carboxylic acid imide hydrochloride.

Abstract: A novel class of monomeric emulsion stabilizers consists of certain types of ethylenically-unsaturated radicals covalently linked to a quaternary nitrogen atom which in turn is covalently linked to a lipophilic radical. Such monomers will polymerize with other ethylenically-unsaturated radicals forming self-stabilized, surfactant-free polymeric dispersions.

Abstract: Novel salts of .alpha.-substituted-.beta.-sulfosuccinic acids having the general formula: ##EQU1## wherein R is hydrogen or an organic moiety, Z is selected from the group consisting of O, S, SO, SO.sub.2, N and NO and M is an alkali metal, ammonium or substituted ammonium cations, useful as detergents and/or detergent builders and detergent compositions containing same.

Abstract: Compounds represented by the formula ##EQU1## wherein M is alkali metal and acids thereof are useful intermediates for preparation of sequestrant compounds represented by the formula ##EQU2## and acids thereof.

Abstract: Organic compounds are prepared by a novel method of conjugate addition in which a donor compound including a carbanion derived from an activated methylidyne group is treated with an acceptor compound including a carbon-carbon unsaturated bond conjugated with an onium ion derived from a polar functional group. The method has particular application as a step in the production of novel intermediates and novel pharmacologically active compounds as disclosed in the Applicants' co-pending application of even date.

Abstract: Compounds having a mercaptoethyl group are prepared by reacting an aqueous thiocyanate solution with ethylene oxide in the presence of an inert water immiscible organic solvent to form ethylene sulfide and then reacting the organic phase with a polar organic compound, preferably a secondary amine.

Abstract: The present invention relates to amine, alkali metal and alkaline earth metal salts of N-benzene sulfonyl carbamic acid esters and to lower alkenyl N-benzene sulfonyl carbamates. These compounds are useful as herbicides.

Abstract: The production of anthraquinone-1-carboxylic acid by reacting a benzoyl halide with a tert.-butylxylene in the presence of ferric chloride, adding aluminum chloride, oxidizing the dimethylbenzophenone formed and cyclizing the resulting benzophenonedicarboxylic acid. The product is a starting material for the production of dyes and pesticides.

Abstract: A process for the manufacture of aminoanthraquinones from nitroanthraquinone, wherein the nitroanthraquinones are treated with ammonia in dipolar aprotic solvents that are inert towards ammonia and nitroanthraquinones.

Abstract: Improved curing agents having long pot life for use with urethane elastomers are prepared by reacting orthochloroaniline, an ester of anthranilic acid, and formaldehyde in selected molar ratios in an acid medium.

Abstract: Pure 1-nitro-anthraquinone is produced by nitrating anthraquinone in aqueous hydrogen fluoride containing about 5 - 30 weight percent of water with nitric acid as nitrating agent at about 0.degree. - 150.degree.C preferably 20.degree. - 70.degree.C.

Abstract: Addition of non-transitional bismuth ion to oxidation catalysis provided by heavy, transition metal-bromine ion combination containing both cobalt and manganese ions uniquely increases catalytic activity of said combination for converting ortho substituted methyl groups to corresponding carboxylic acid groups on benzene nucleus by a factor much greater than by the addition of equivalent amount of such high catalytically active heavy, transition metal as cobalt and manganese. Such greater catalytic activity is manifested by longer sustained initial rapid rate of oxygen consumption and higher o-dicarboxybenzene yield.

Abstract: Process for the manufacture of pure 1-nitroanthraquinone, characterised in that a nitroanthraquinone mixture obtained by nitration of anthraquinone in the presence of inorganic acids and, optionally, lowering the molar fraction of the acids in the reaction mixture after isolation of the reaction products which have precipitated and, optionally, further measures, is subjected to a rectification.

Abstract: A two-stage process for producing para-aminobenzoic acid by first reacting certain lower alkyl or glycol monoesters of terephthalic acid or specific salts thereof or mixtures thereof with ammonia in liquid phase at elevated temperatures and pressures to obtain a terephthalic acid monoamide intermediate, removing substantially all ammonia from this intermediate and then converting it into the para-aminobenzoic acid product by the Hofmann reaction, preferably using a sodium hypochlorite solution. The para-aminobenzoic acid, either as the free acid or in the form of its salts or esters is a known product having many uses.

Abstract: This invention is for phosphinoline and phosphindoline compounds having the formula,Wherein n is 0 or 1; X is 0 or S; R.sup.3 is hydrogen or methyl; R.sup.5 is hydrogen or methyl, or may be bound to R.sup.13 to form a morpholino, piperidino or pyrrolidino ring; R.sup.7 is hydrogen or hydroxy; R.sup.11 and R.sup.12 are hydrogen; R.sup.13 is methyl, or R.sup.13 and R.sup.5 may be joined together as above stated to form a morpholino, piperidino, or pyrrolidino ring. The compounds are analgesics.

Abstract: A method for producing mixtures containing greater than 50% cis 2-methyl-3-pentenoic acid comprising first reacting methyl acetylene with a methyl magnesium halide to form a methylacetylene magnesium halide Grignard reagent; then reacting the methyl acetylene magnesium halide Grignard reagent with acetaldehyde to form a 3-pentyn-2-ol magnesium halide salt; then hydrolyzing the magnesium halide salt to form 3-pentyn-2-ol; then halogenating the 3-pentyn-2-ol to form a 4-halo-2-pentyne; then reacting magnesium with the 4-halo-2-pentyne to produce a 4-magnesium halo-2-pentyne Grignard reagent; then reacting the 4-magnesium halo-2-pentyne Grignard reagent with carbon dioxide to form a magnesium halo-carboxylate salt mixture of compounds having the structures: ##EQU1## (wherein X is halogen); then hydrolyzing the magnesium halo-carboxylate salt mixture to form a mixture of carboxylic acids having the structures: ##EQU2## then hydrogenating the aforementioned mixture of carboxylic acids to form a mixture containing

Abstract: Preparation of very pure 1-nitroanthraquinone by heating 1-nitroanthraquinone which contains dinitroanthraquinone with the aqueous solution of a salt of sulphurous acid in the presence of an inert organic solvent.

Abstract: Novel benzoylphenylacetic acid derivatives of the formula ##SPC1##Wherein X is selected from the group consisting of geranyloxy, pivaloyloxymethoxy and, ##EQU1## Z is alkyl of 1 to 4 carbon atoms and Y is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms having anti-inflammatory and analgesic activity.

Abstract: The invention discloses 1-tertiary-butyl-3-morpholino-3-phenyl-2,1-benzisoxazolines having pharmacological activity in animals and useful, for example, as hypolipidemic agents. The compounds may be prepared by reacting a 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium quaternary salt, e.g., 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium tetrafluoroborate with morpholine. The 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium quaternary salt may be prepared by reaction of a corresponding 3-phenyl-2,1-benzisoxazole with tertiary-butanol in the presence of a strong inorganic acid.