Patents Examined by Luan V. Van
-
Patent number: 11598747Abstract: A blood pH measurement device comprises a tube through which blood or other ion-containing fluid flows, at least one dry reference electrode, a proton diffusion differentiator, an ion-sensitive field-effect transistor, and a pH meter. The tube can comprise an annular wall with an entry, an exit, and a sensor floor. The dry reference electrode is preferably located within the tube between the entry and the exit and opposite the sensor floor. It is also contemplated that the dry reference electrode is surrounded by a membrane and is, at least partially, associated with the interior surface of the annular wall. The contemplated invention can also include a proton diffusion differentiator, such as an electrolyte separation layer, connecting the external surface of the sensor floor to an ion-selective field effect transistor (ISFET), wherein the ISFET measures the ion concentration of the blood.Type: GrantFiled: December 13, 2017Date of Patent: March 7, 2023Assignee: Sentient Technologies, Inc.Inventors: Harold Mark Bain, Fredrick Quincy Johnson, Henry Roskos
-
Patent number: 11592421Abstract: Disclosed are methods for performing capillary electrophoresis on two or more nucleic acid samples. The methods employ a forward voltage to move a first sample forward from an inlet to an interrogation region in the capillary, then a backward voltage to move the first sample backward, and then a forward voltage again to move the first sample and a second sample forward. Systems and apparatuses for performing capillary electrophoresis are also provided.Type: GrantFiled: May 22, 2018Date of Patent: February 28, 2023Assignee: INTEGENX, INC.Inventors: Mattias Vangbo, David King, Arnaldo Barican
-
Patent number: 11585803Abstract: An analysis method using a microchip which is provided with a capillary flow path, and a sample reservoir connected to the capillary flow path, in which the capillary flow path is filled with a first liquid for electrophoresis, and a second liquid containing a sample is stored in the sample reservoir, and including a pressurization process in which the first liquid is pressurized into the capillary flow path from a side of the capillary flow path that is opposite from the side connected to the sample reservoir, and a separation process in which a voltage is applied between the sample reservoir storing the second liquid and the capillary flow path filled with the first liquid, such that components in the sample contained in the second liquid move in the capillary flow path and the components are separated in the capillary flow path.Type: GrantFiled: July 8, 2019Date of Patent: February 21, 2023Assignee: ARKRAY, INC.Inventor: Naotsugu Onuma
-
Patent number: 11585780Abstract: The present disclosure relates to a potentiometric probe for measuring a measured variable that represents an ion concentration in a measuring medium, including a probe base including a sensor circuit, and two electrochemical half-cells arranged such that one of the half-cells surrounds at least one portion of the other half-cell, wherein at least one of the half-cells is configured as a module which is connected to the probe base via a mechanical and electrical interface. In another embodiment, one of the half-cells is a measuring half-cell including an ion-selective membrane and a terminal lead which electrically contacts the ion-selective membrane. The other half-cell is a reference half-cell, wherein the measuring half-cell and/or the reference half-cell are each configured as a module which is connected to the probe base via a mechanical and electrical interface.Type: GrantFiled: June 15, 2020Date of Patent: February 21, 2023Assignee: Endress+Hauser Conducta GmbH+Co. KGInventors: Michael Hanko, Thomas Wilhelm, Matthäus Speck, Detlev Wittmer, Manfred Jagiella
-
Patent number: 11585784Abstract: Techniques described herein can apply AC signals with different phases to different groups of nanopore cells in a nanopore sensor chip. When a first group of nanopore cells is in a dark period and is not sampled or minimally sampled by an analog-to-digital converter (ADC) to capture useful data, a second group of nanopore cells is in a bright period during which output signals from the second group of nanopore cells are sampled by the analog-to-digital converter. The reference level setting of the ADC is dynamically changed based on the applied AC signals to fully utilize the dynamic range of the ADC.Type: GrantFiled: February 8, 2021Date of Patent: February 21, 2023Assignee: Roche Sequencing Solutions, Inc.Inventors: J. William Maney, Jr., Santiago Fernandez-Gomez
-
Patent number: 11561194Abstract: Disclosed is a gas sensor element having: a solid electrolyte body containing oxygen-ion conductive ZrO2; a detection electrode disposed on the solid electrolyte body to be exposed to a gas under measurement; and a reference electrode disposed on the solid electrolyte body to be exposed to a reference gas. In the gas sensor element, the detection electrode contains Pt and ZrO2; the detection electrode has a thickness of 3 to 10 ?m; the amount of ZrO2 contained relative to Pt in the detection electrode is 12 to 18 wt %; the detection electrode has a porosity of 5% or lower; and, in a particle size distribution graph of ZrO2 particles in the detection electrode, a cumulative value of peaks appearing in a range of 0.025 ?m to 0.200 ?m is 60 to 75%, and a cumulative value of peaks appearing in a range of 1.000 ?m to 3.162 ?m is 2 to 7%.Type: GrantFiled: March 6, 2019Date of Patent: January 24, 2023Assignee: NGK SPARK PLUG CO., LTD.Inventors: Midori Matsumura, Hiroshi Isomura, Kazuki Yoshioka, Ryosuke Ota
-
Patent number: 11549905Abstract: A fluid analyzer for analyzing fluid samples comprising one or more analytes and a method of calibrating such. The fluid analyzer includes a control system to control at least one automated valve to pass at least three calibration reagents through a fluid channel to a secondary ion selective electrode, a primary ion selective electrode, and a reference electrode, and determine calibration information using calibration logic from signals generated by a meter, control the at least one automated valve to selectively pass different subsets of the at least three calibration reagents through the fluid channel to the secondary ion selective electrode, the primary ion selective electrode, and the reference electrode, and determine re-calibration information using the signals generated by the meter and at least one of the calibration information and re-calibration logic.Type: GrantFiled: July 9, 2020Date of Patent: January 10, 2023Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Wei Zhang, Brian Holman, Kevin Horan
-
Patent number: 11506626Abstract: An electrode composed of a substrate including a graphene layer coated on a first metal; and a complex including a second metal deposited on the substrate and a hydroxide of the first metal, where the complex is in the form of core-shell in which the second metal is a core and the hydroxide of the first metal is a shell, and the second metal has a higher standard reduction potential than the first metal. The graphene-coated metal foam of the present invention is the first case that proves not only theoretically but also by experiment that the remarkable catalytic ability reducing other metals (Au, Pt, Ag, and Cu, etc.) with a higher reduction potential than the metal by graphene coated on the metal surface it electroless deposition without additional reductant or electrical reduction conditions is due to the electrical double layer or interfacial dipole induced between the graphene and the metal.Type: GrantFiled: March 7, 2019Date of Patent: November 22, 2022Assignees: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY, GLOBAL FRONTIER CENTER FOR MULTISCALE ENERGY SYSTEMSInventors: Jong Sung Yu, Chunfei Zhang
-
Patent number: 11493477Abstract: An electrophoresis method, system, and gel recover biological substances from the gel with high efficiency. The method uses an electrophoresis gel having an injection hole into which biological substances are injected and a recovery hole from which the biological substances are recovered. The electrophoresis method includes injecting the biological substances into the injection hole, and applying an electric field penetrating the injection and recovery holes. A vertical axis in a downward direction as a positive direction is set as an X-axis, an axis which is perpendicular to the X-axis is set as a Y-axis, and coordinates of a bottom of the recovery hole are set as (XC, YC). The X coordinate XC of the bottom of the recovery hole satisfies XC>X1 when the biological substance is electrophoresed to coordinates (X1, YC) in the recovery hole from a bottom of the injection hole in the applying the electric field.Type: GrantFiled: May 28, 2019Date of Patent: November 8, 2022Assignee: Hitachi High-Tech CorporationInventors: Mima Ogawa, Takahide Yokoi, Chihiro Uematsu
-
Patent number: 11486851Abstract: A gas sensor comprises an electrochemical film, a plurality of electrodes coupled with the electrochemical film and a semiconductor wafer coupled with the plurality of electrodes. A passivation layer is formed between the electrochemical firm and the semiconductor wafer and a dielectric layer is coupled between the electrochemical film and the semiconductor wafer.Type: GrantFiled: September 18, 2018Date of Patent: November 1, 2022Assignee: ams AGInventors: Filip Frederix, Erik Jan Lous
-
Patent number: 11486855Abstract: The present disclosure relates to an electrochemical sensor for determining a measurand correlating with a concentration of an analyte in a measuring fluid, comprising: a sensor membrane designed to be in contact with the measuring fluid for detecting measured values of the measurand; a probe housing which has at least one immersion region designed for immersion into the measuring fluid, wherein the sensor membrane is arranged in the immersion region of the probe housing; and a measurement circuit which is at least partially contained in the probe housing and is designed to generate and output a measurement signal dependent on the measurand, wherein the sensor membrane contains an optically detectable substance for marking the sensor membrane.Type: GrantFiled: November 26, 2019Date of Patent: November 1, 2022Assignee: ENDRESS+HAUSER CONDUCTA GMBH+CO. KGInventors: Andreas Löbbert, Michael Hanko
-
Patent number: 11474071Abstract: An embodiment provides a method for compensating for inteferants in measurement of alkalinity in a reagent-less system, including: introducing an aqueous sample into a measurement device comprising one or more series of electrodes; applying an electrical signal to the aqueous sample using the one or more series of electrodes, wherein the electrical signal is selected from the group consisting of: current and voltage; identifying, during application of the electrical signal, that the electrical signal reaches an oxidation threshold and measuring, prior to reaching the oxidation threshold, a first electrical response to the electrical signal, the first electrical response attributable to interferants in the aqueous sample; identifying, during application of the electrical signal, that the electrical signal reaches an endpoint and measuring, from the oxidation threshold to the endpoint, a second electrical response to the electrical signal; and measuring an alkalinity of the aqueous sample based upon a differencType: GrantFiled: August 31, 2020Date of Patent: October 18, 2022Assignee: HACH COMPANYInventors: Vishnu Vardhanan Rajasekharan, Corey Alan Salzer
-
Patent number: 11467120Abstract: A gas sensor includes a gas sensor element for detecting a specific gas concentration in measured gas. The gas sensor element includes a solid electrolyte, a measured gas side electrode into which measured gas is introduced through a porous diffusion resistance layer, a reference gas side electrode facing a reference gas chamber, and a diffusion space portion between the porous diffusion resistance layer and the measured gas side electrode. The porous diffusion resistance layer has a measured gas inlet opened to an element outer surface and a measured gas outlet opened to the diffusion space portion. A relationship between a distance between the inlet and the outlet and a distance between the outlet and the measured gas side electrode is expressed by 0<L1/(L1+L2)<0.4.Type: GrantFiled: October 25, 2019Date of Patent: October 11, 2022Assignee: DENSO CORPORATIONInventors: Yasutaka Kamiya, Tatsuki Ujiyama
-
Patent number: 11467124Abstract: Methods for in situ measurement of an oxidation reduction potential (ORP) and pH of a solution comprising iron are provided. The methods comprise measuring a kinetic parameter at an electrode surface of an electrode system comprising a working electrode, a counter electrode and a pseudo-reference electrode, wherein the kinetic parameter is associated with ferric reduction or both ferric reduction and ferrous oxidation and comparing the kinetic parameter to calibration data for the electrode system to determine the ORP and pH of the solution. Also provided are apparatus and systems for in situ measurement of an ORP and pH of a solution comprising iron. The apparatus and systems comprise an electrode system comprising a working electrode, a counter electrode and a pseudo-reference electrode and a detector for measuring a kinetic parameter at an electrode surface of the electrode system.Type: GrantFiled: May 2, 2018Date of Patent: October 11, 2022Assignee: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Edouard Asselin, Hamidreza Zebardast, Jing Liu
-
Patent number: 11428665Abstract: Structures for improved electrophoretic precast gel substrates are disclosed herein. In some embodiments, an electrophoretic precast gel substrate includes a front plate comprising a first tenon-and-mortise connective structure, and a rear plate comprising a second tenon-and-mortise connective structure. The front plate and the rear plate can include snap features that are configured to provide a snap fit with a corresponding structure. The front and rear plates can be configured to be coupled and/or decoupled along the first and second tenon-and-mortise connective structures.Type: GrantFiled: April 21, 2020Date of Patent: August 30, 2022Inventors: Junjie Zhang, Rui Duan, Xin Chen, Boyan Zhang
-
Patent number: 11391689Abstract: A gas sensor includes a sensor element and one or more hollow columnar dense bodies. The sensor element includes an element main body having a side surface, a porous layer and a water-penetration reduction portion that cover at least a front end-side part of the side surface. The water-penetration reduction portion disposed on the side surface so as to divide the porous layer an overlap length W that is the length of a continuous overlap between a range in which the water-penetration reduction portion is present in the longitudinal direction and a range in which inner peripheral surfaces of the one or more dense bodies are present in the longitudinal direction being 0.5 mm or more, the water-penetration reduction portion being a gap region in which the porous layer is absent, the water-penetration reduction portion reduces the capillarity of water.Type: GrantFiled: October 31, 2019Date of Patent: July 19, 2022Assignee: NGK INSULATORS, LTD.Inventors: Yuki Nakayama, Shota Kageyama, Yusuke Fujii, Kei Kosaka
-
Patent number: 11391691Abstract: A gas sensor includes a sensor element and one or more hollow columnar dense bodies. The sensor element includes an element main body having a side surface, a porous layer and a water-penetration reduction portion that cover at least a front end-side part of the side surface. The water-penetration reduction portion disposed on the side surface so as to divide the porous layer or to be located closer to the rear end than the porous layer, an overlap length W that is the length of a continuous overlap between a range in which the water-penetration reduction portion is present in a longitudinal direction and a range in which inner peripheral surfaces of the one or more dense bodies are present in the longitudinal direction being 0.5 mm or more, and having a dense layer covers the side surface, the water-penetration reduction portion reduces the capillarity of water.Type: GrantFiled: October 31, 2019Date of Patent: July 19, 2022Assignee: NGK INSULATORS, LTD.Inventors: Yuki Nakayama, Shota Kageyama, Yusuke Fujii, Kei Kosaka
-
Patent number: 11384675Abstract: The control section of a control apparatus executes a first control for operating a voltage application section such as to cause a current to flow in a first direction through a gas sensor in a first period, and a second control for operating the voltage application section such as to cause a current to flow in a second direction, opposite to the first direction, through the gas sensor in a second period. The control apparatus changes the length of at least one of the first period and the second period based on a comparison between a first measurement value, which is the absolute value of a value measured by a sweep measurement section during execution of the first control, and a second measurement value, which is the absolute value of a value measured by the sweep measurement section during execution of the second control.Type: GrantFiled: March 15, 2018Date of Patent: July 12, 2022Assignees: DENSO CORPORATION, MAZDA MOTOR CORPORATIONInventors: Tooru Matsumoto, Katsuhide Akimoto, Takahito Masuko, Keita Takagi, Tatsuhiro Ito, Yuki Sato, Ryo Teramoto, Takafumi Nishio
-
Patent number: 11376597Abstract: A method of operating an electrowetting on dielectric (EWOD) device performs electrowetting operations on fluids dispensed into the EWOD device, which provides enhanced operation for using multiple non-polar filler fluids.Type: GrantFiled: July 8, 2019Date of Patent: July 5, 2022Assignee: Sharp Life Science (EU) LimitedInventors: Lesley Anne Parry-Jones, Emma Jayne Walton
-
Patent number: 11371006Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: —receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); —receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measured aType: GrantFiled: October 28, 2016Date of Patent: June 28, 2022Assignee: Hoffman-La Roche, Inc.Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair