Patents Examined by Lucy M Tien
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Patent number: 12369587Abstract: The present invention is directed to an aqueous composition comprising a mixture of epyrifenacil, flumioxazin and pyroxasulfone. The present invention is further directed to methods of controlling weeds by applying the compositions of the present invention to a weed or an area in need of weed control.Type: GrantFiled: November 30, 2021Date of Patent: July 29, 2025Assignee: VALENT U.S.A., LLCInventors: Takashi Shibayama, Ke Zhou
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Patent number: 12357730Abstract: The present disclosure provides bio-material composition, comprising a dry potassium phosphate based mixture comprising: MgO, monobasic potassium phosphate, monobasic sodium phosphate, proteoglycans, calcium sodium phosphosilicate, and a plurality of spherically-shaped polymers, wherein a weight percent ratio of monobasic potassium phosphate to MgO is between about 3:1 and 1:1, wherein the dry potassium phosphate based mixture is configured to be mixed with the aqueous solution to thereby form a reabsorbable bio-material slurry, wherein the spherically-shaped polymers are between about 1-5 weight percent of the dry composition, and wherein the spherically-shaped polymers are absorbed faster than the remaining components of the reabsorbable bio-material slurry to thereby form pockets within the bio-material composition that enhance reabsorption of the bio-material composition.Type: GrantFiled: October 19, 2022Date of Patent: July 15, 2025Assignee: Bone Solutions, Inc.Inventor: Frankie L. Morris
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Patent number: 12343406Abstract: An immunoreactive substance carrier according to an embodiment of the present invention may stably deliver various immunoreactive substances including antibodies and/or cytokines, to a target site, thereby exhibiting excellent immunotherapeutic effects. Therefore, a composition including the immunoreactive substance carrier can be used for immunotherapy, thereby having excellent effects in the prevention or treatment of cancer or various immune diseases.Type: GrantFiled: June 3, 2019Date of Patent: July 1, 2025Assignee: LEMONEX INC.Inventor: Cheol Hee Won
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Patent number: 12318484Abstract: Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided.Type: GrantFiled: December 23, 2021Date of Patent: June 3, 2025Assignees: Access to Advanced Health Institute, University of Virginia Patent FoundationInventors: Christopher B. Fox, Susan S. Lin, Darrick Carter, Neal Van Hoeven, Mayuresh M. Abhyankar, William A. Petri
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Patent number: 12280024Abstract: Pharmaceutical compositions comprising epinephrine, methods of administration, and methods of making the same. Compositions may comprise at least one of an active agent, a pH raising agent, an antioxidant, a transition metal complexing agent, a pH lowering agent, a tonicity regulating agent, optionally a preservative, and optionally a solvent.Type: GrantFiled: September 28, 2023Date of Patent: April 22, 2025Assignee: ENDO OPERATIONS LIMITEDInventors: Suketu Sanghvi, Vinayagam Kannan, Matthew Kenney
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Patent number: 12274772Abstract: The present invention is directed to a kit-of-parts for bleaching keratin fibers, having a bleaching composition A comprising a) one or more persalt(s) and/or peroxy salt(s), and b) one or more alkalizing agent(s), an aqueous oxidizing composition B, and a composition C comprising c) one or more non-acetylated sugar alcohol(s), and/or their mixtures, wherein the bleaching composition A comprises less than 5% by weight of water, calculated to the total weight of the bleaching composition A.Type: GrantFiled: February 25, 2022Date of Patent: April 15, 2025Assignee: KAO CORPORATIONInventors: Peter Bauer, Steven Breakspear, Bernd Nöcker, Ines Rabelo De Moraes
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Patent number: 12226531Abstract: The present invention relates to a composition for feeding a ruminant comprising i) a non-protein nitrogen compound, and ii) a coating surrounding the non-protein nitrogen compound, wherein said coating comprises one or more layers of a mixture of a saturated fat and a fatty acid, and said coating comprises from 60 wt.-%+/?10% to 85 wt.-%+/?10% of the saturated fat, e.g. hydrogenated fat, and from 15 wt.-%+/?10% to 40 wt.-%+/?10% of the fatty acid, each based on the total weight of the coating; a process for the preparation of said composition and its uses, e.g., for improving nitrogen utilization in a ruminant.Type: GrantFiled: September 27, 2018Date of Patent: February 18, 2025Assignee: Evonik Operations GmbHInventors: Thomas Haeussner, Frank Fischer, Georg Borchers, Ulrike Kottke, Christoph Kobler, Cornelia Borgmann, Karsten Portner
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Patent number: 12220484Abstract: The present invention relates to aqueous lipid and/or liposome formulations with an increased chemical stability, to methods of preparing such aqueous formulations as well as to kits comprising them. The present invention further relates to methods of preparing lipid-based pharmaceutical compositions, to pharmaceutical compositions prepared by such methods and to methods of chemically stabilizing aqueous lipid and/or liposome formulations.Type: GrantFiled: October 6, 2021Date of Patent: February 11, 2025Assignee: BioNTech SEInventors: Heinrich Haas, Isaac Hernan Esparza Borquez
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Patent number: 12220482Abstract: An object of the present invention is to provide a liposome composition containing a liposome having an excellent leakage rate of a nucleic acid analog anticancer agent, and a method for producing the same. According to the present invention, there are provided a liposome composition containing a liposome which (1) contains a nucleic acid analog anticancer agent and in which (2) a content ratio of a lysophospholipid contained in a lipid forming the liposome with respect to a total amount of phospholipids other than the lysophospholipid contained in the lipid forming the liposome is 0.01 mol % to 5 mol % and (3) a nucleic acid analog anticancer agent/lipid ratio is 2 mass % to 10 mass %, and a method for producing the same.Type: GrantFiled: January 4, 2021Date of Patent: February 11, 2025Assignee: FUJIFILM CorporationInventors: Takahiro Sekiguchi, Mikinaga Mori, Kentaro Numajiri, Hiroyuki Kitaoka
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Patent number: 12214079Abstract: The present invention relates to drug delivery vehicles comprising micronized particles that include an active lipid agent, and in particular to micronized lipid particles that comprise an ether lipid such as sn-1-O-eicosanyl-sn-2-palmitoyl-glycerol and its isomers.Type: GrantFiled: May 3, 2021Date of Patent: February 4, 2025Assignee: MCAL Therapeutics Inc.Inventor: Thomas Gadek
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Patent number: 12214080Abstract: The present invention relates to drug delivery vehicles comprising micronized particles that include an active lipid agent, and in particular to micronized lipid particles that comprise an ether lipid such as sn-1-O-eicosanyl-sn-2-palmitoyl-glycerol and its isomers.Type: GrantFiled: May 3, 2021Date of Patent: February 4, 2025Assignee: MCAL Therapeutics Inc.Inventor: Thomas Gadek
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Patent number: 12214077Abstract: The present invention provides a pharmaceutical composition for the lubrication of joints, the pharmaceutical composition comprising a non-ionic tonicity agent comprising a polyol, and liposomes comprising at least one membrane comprising at least one phospholipid (PL) selected from a glycerophospholipid (GPL), said GPL having two C12-C18 hydrocarbon chains, being the same or different, and sphingomyelin (SM) having a C12-C18 hydrocarbon chain, the pharmaceutical composition being essentially free of an additional pharmaceutically active agent, wherein the at least one membrane has a phase transition temperature in the range of about 20° C. to about 39° C. and the joint has a joint temperature which is above the phase transition temperature.Type: GrantFiled: August 15, 2021Date of Patent: February 4, 2025Assignee: MOEBIUS MEDICAL LTD.Inventors: Yechezkel Barenholz, Yaniv Dolev, Keren Turjeman, Gadi Sarfati, Maty Ayal-Hershkovitz
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Patent number: 12214072Abstract: The present disclosure provides chewable tablets comprising (i) a compressed core including a bioactive molecule; (ii) a protective layer over said compressed core, and (iii) one or more soft-coating layers over said protective layer, each soft coating layer comprises gum base powder; wherein the protective layer comprises water-insoluble cellulose based polymers, preferably ethyl cellulose based polymer.Type: GrantFiled: November 4, 2019Date of Patent: February 4, 2025Assignee: AMBROSIA SUPHERB LTD.Inventor: Sharon Raz
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Patent number: 12178824Abstract: An orodispersible formulation for contraception or hormone replacement therapy containing an estrogen and a progestogen that has sufficient hardness, disintegration time and friability.Type: GrantFiled: October 14, 2022Date of Patent: December 31, 2024Assignee: Millicent Pharma LimitedInventors: Ryan Loughlin, Roger M. Boissonneault
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Patent number: 12144882Abstract: Disclosed is a method of improving the appearance of skin with a low-pH skin care composition that contains hydroxycinnamic acid (HCA) and a vitamin B3 compound in a synergistic combination.Type: GrantFiled: November 29, 2022Date of Patent: November 19, 2024Assignee: The Procter & Gamble CompanyInventors: Matthew Clair Ehrman, Tomohiro Hakozaki, John Erich Oblong, Dissanayake Mudiyanselage Mahathma Bandara Dissanayake, Wan Ting Chung
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Patent number: 12128123Abstract: The present disclosure is directed to providing a moldable solid washing agent composition and an article molded from the same. The composition of the present disclosure can be stored easily at room temperature for a long time. It is applicable to a system that can be manufactured on site and can satisfy customer needs because it can be molded immediately by a simple method and the shape, size, etc. can be controlled. In addition, the solid washing agent composition disclosed in the present specification has superior compatibility with water.Type: GrantFiled: March 3, 2022Date of Patent: October 29, 2024Assignee: AMOREPACIFIC CORPORATIONInventors: Daeun Kim, Bohyun Seo, Chang Jo Jung, Taewon Seo, Jiyeon Han
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Patent number: 12121613Abstract: The invention relates to lipophilic transport particles for cosmetic or pharmaceutical active ingredients. The lipophilic transport particles comprise polyglycerol fatty acid ester as a main constituent and, because of the absence of polymorphic transformations, even during long storage, neither have volume changes nor allow the problem of expulsion of the adhering or enclosed active ingredient, due to intense structuring of the crystal lattice and associated compaction, to arise, and therefore the degree of loading with active ingredient and the release profile are stable.Type: GrantFiled: July 1, 2019Date of Patent: October 22, 2024Assignee: IOI OLEO GMBHInventors: Dirk Lochmann, Sebastian Reyer, Sharareh Salar Behzadi, Michael Stehr, Andreas Zimmer
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Patent number: 12114615Abstract: Compositions suitable for use as biodegradable coatings, comprising mixtures of naturally sourced waxes and naturally sourced crosslinkable agents. Compositions may be used to impart water resistance to a substrate, to control the release time of soil nutrients, to reduce environmental damage, and to protect seed or crop damage from high local concentrations of salts. Compositions are preferably prepared as aliphatic alcohol and thereafter may be disposed about an agronomically important substrate core or a fibrous substrate, at temperatures below about 90° C. to impart water resistance or extend the storage time.Type: GrantFiled: December 24, 2021Date of Patent: October 15, 2024Inventor: Richard Thomas Johnston
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Patent number: 12115259Abstract: Improved spherical beads that may be used in producing pharmaceutically active pellets by depositing a pharmaceutically active agent on the surface of said spherical beads. The spherical beads includes a pharmaceutically acceptable carrier material, including: a) at least 60 wt. % of phosphoric acid calcium salt and b) up to 40 wt. % of organic material. Greater than or equal to 90 wt % of the spherical beads have a particle size in the range of from 90 ?m to 1200 ?m. The spherical beads have: a bulk density of at least or more than 1000 g/l, a specific surface area of at most or less than 10 m2/g, and a hardness of at least or more than 600 g/mm2. Also included is a method for producing such spherical beads and to pharmaceutically active pellets being prepared by depositing a pharmaceutically active agent on the surface of the spherical beads.Type: GrantFiled: September 27, 2019Date of Patent: October 15, 2024Assignee: Chemische Fabrik Budenheim KGInventors: Tobias Heß, André Huhn, Christian Koch, Markos Papaioannou, Daniel Zakowiecki
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Patent number: 12089594Abstract: The invention relates to stable liquid compositions comprising cyclohexanedione oxime herbicides (preferably clethodim), a water miscible solvent (preferably alkyl benzene), and at least one non-ionic surfactant (preferably mixture of lower HLB surfactant with higher HLB surfactant, or alternatively mixture of high HLB surfactants and fluroxypyr meptyl) and uses thereof.Type: GrantFiled: September 10, 2019Date of Patent: September 17, 2024Assignee: ADAMA AGAN LTD.Inventors: Tiago Elias Da Silva, Silvio Luiz Machado, Luiz Fernando Colla, Lior Ziserman, Ronly Shapira, Sergio Nahmoud