Abstract: An orodispersible formulation for contraception or hormone replacement therapy containing an estrogen and a progestogen that has sufficient hardness, disintegration time and friability.

Abstract: Disclosed is a method of improving the appearance of skin with a low-pH skin care composition that contains hydroxycinnamic acid (HCA) and a vitamin B3 compound in a synergistic combination.

Abstract: The present disclosure is directed to providing a moldable solid washing agent composition and an article molded from the same. The composition of the present disclosure can be stored easily at room temperature for a long time. It is applicable to a system that can be manufactured on site and can satisfy customer needs because it can be molded immediately by a simple method and the shape, size, etc. can be controlled. In addition, the solid washing agent composition disclosed in the present specification has superior compatibility with water.

Abstract: The invention relates to lipophilic transport particles for cosmetic or pharmaceutical active ingredients. The lipophilic transport particles comprise polyglycerol fatty acid ester as a main constituent and, because of the absence of polymorphic transformations, even during long storage, neither have volume changes nor allow the problem of expulsion of the adhering or enclosed active ingredient, due to intense structuring of the crystal lattice and associated compaction, to arise, and therefore the degree of loading with active ingredient and the release profile are stable.

Abstract: Improved spherical beads that may be used in producing pharmaceutically active pellets by depositing a pharmaceutically active agent on the surface of said spherical beads. The spherical beads includes a pharmaceutically acceptable carrier material, including: a) at least 60 wt. % of phosphoric acid calcium salt and b) up to 40 wt. % of organic material. Greater than or equal to 90 wt % of the spherical beads have a particle size in the range of from 90 ?m to 1200 ?m. The spherical beads have: a bulk density of at least or more than 1000 g/l, a specific surface area of at most or less than 10 m2/g, and a hardness of at least or more than 600 g/mm2. Also included is a method for producing such spherical beads and to pharmaceutically active pellets being prepared by depositing a pharmaceutically active agent on the surface of the spherical beads.

Abstract: Compositions suitable for use as biodegradable coatings, comprising mixtures of naturally sourced waxes and naturally sourced crosslinkable agents. Compositions may be used to impart water resistance to a substrate, to control the release time of soil nutrients, to reduce environmental damage, and to protect seed or crop damage from high local concentrations of salts. Compositions are preferably prepared as aliphatic alcohol and thereafter may be disposed about an agronomically important substrate core or a fibrous substrate, at temperatures below about 90° C. to impart water resistance or extend the storage time.

Abstract: The invention relates to stable liquid compositions comprising cyclohexanedione oxime herbicides (preferably clethodim), a water miscible solvent (preferably alkyl benzene), and at least one non-ionic surfactant (preferably mixture of lower HLB surfactant with higher HLB surfactant, or alternatively mixture of high HLB surfactants and fluroxypyr meptyl) and uses thereof.

Abstract: The present disclosure provides an arctigenin liquid nano-preparation and a preparation method thereof, and relates to the technical field of pharmaceutical preparation. In the present disclosure, arctigenin is prepared into a liquid nano-preparation, having advantages of distribution of a droplet diameter on nanoscale, significantly increased specific surface area, rapid absorption, and high bioavailability. Meanwhile, nano-preparation entered the body can be captured by wandering leucocytes, and a medicament is delivered to inflammatory lesions through chemiotaxis, thereby conferring a targeted drug delivery feature on the arctigenin and making a therapy more targeted.

Abstract: Synthesis of a compound N-(pyrimidin-2-ylcarbamothioyl) benzamide and its use as an insecticidal agent.

Abstract: In the instant disclosure relates to a leave-on hair treatment composition and to methods for treating hair using the hair treatment composition. The hair treatment composition include: (a) water; (b) about 5 to about 40 wt. % of one or more polyols chosen from glycerin, ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, diethylene glycol, dipropylene glycol, 1,3 propanediol, and a mixture thereof; (c) at least 20 wt. % of one or more oils; and (d) at least 0.5% of one or more C1-C9 non-polymeric and non-thiol, mono-, di-, and/or tri-carboxylic acids; and the ratio of ((a)+(b)) to (c) is about 1:1 to about 1:5. The composition imparts durability, hydration, and moisturization to hair in addition to desirable styling effects.

Abstract: The invention discloses a treatment composition to treat nasal or oral dryness and allergy symptoms, and a method for using the same. Certain compositions include xylitol, at least two wetting agents, an aqueous carrier, and other active ingredients, such as a potassium salt, a sodium salt, and a preservative. The composition may be configured as a nasal or oral spray, and oral rinse, or a nasal gel.

Abstract: One aspect of the present disclosure is a sheet type mask gel composition including a polyol, a water-soluble thickener, and water, wherein adhesive strength is maintained for a long time, a mask sheet including the same, and a method of manufacturing the mask sheet.

Abstract: The present invention introduces an ophthalmic solution containing halo-fullerenes. When the spherical fullerene carbon cages are functionalized with halogens, the resulting halo-fullerenes demonstrate sustained antimicrobial activity. Fullerenes are also characterized by unique electron properties that impart antioxidant capabilities as free radical scavengers. Nonetheless, far smaller than ocular tissue cells, halo-fullerenes are biocompatible—and capable of penetrating intricate barriers, like the cornea and conjunctiva, with potential to achieve greater efficacy and symptom relief in chronic dry eye than conventional treatments. With remarkable surface area, halo-fullerenes also allow customization and possess a unique molecular architecture for broader applications. This multifunctional solution thus imparts antimicrobial activity, antioxidative protection, molecular lubrication, and shielding from external irritants while penetrating dense ocular structures.

Abstract: The present invention relates to a veterinary supplement composition for preventing colic that includes simethicone and optionally sorbitol. The veterinary supplement composition is administered orally by syringe or mixed with animal feed. The veterinary supplement composition can be liquid or powder. Dosage is determined by body weight from about 1 mL per 400 pounds of body weight to about 1.2 mL per 400 pounds of body weight. Palatants can be added to improve animal taste likability. Such Palatants can include mint, apple, cinnamon, peppermint, banana, and others. The oral supplement can also be used in the prevention of colic in horses.

Abstract: The present invention provides an oral transmucosal film for delivering tadalafil through the buccal mucosa or sublingual mucosa. The film is a single layer structure containing amorphous tadalafil, one or more solubilizers, one or more penetration enhancers, and one or more adhesives to deliver the drug through a transmucosal route. Comparing with an oral tadalafil tablet, the present oral transmucosal film provides improved absorption rate and Tmax. The oral transmucosal film comprises 5%-60% by weight of amorphous tadalafil, 25-96% by weight of a film-forming material, 1-20% by weight of a solubilizer, 0.5-10% by weight of a penetration enhancer, and 1-15% by weight of an adhesive.

Abstract: The present application relates to a composition comprising at least one neutralizing agent, at least one stabilizing agent, at least three chelator agents and at least one cationic agent. Also, the present invention is related to a method for manufacturing the composition, a method for applying the composition onto keratin fibers for shaping or altering the shape of the keratin fibers, particularly hair, a kit that is suitable for performing the claimed method for shaping or altering the shape of the hair and the use of the claimed composition for shaping or altering the shape of the hair.

Abstract: Hair compositions and methods for caring for and providing cosmetic benefits to the hair using the compositions are disclosed. The hair care compositions may include about 50 to about 90 wt. % of a polyol; about 0.1 to about 10 wt. % of fatty compounds, the fatty compounds comprising a carbonate and a fatty ether; about 10 to about 35 wt. % of a monoalcohol; and about 0.1 to about 5 wt. % of a cationic surfactant, wherein all weight percentages are based on the total weight of the hair composition. The hair care composition may be formulated to have a weight ratio of the total amount of carbonate to the total amount of fatty ether is about 3:1 to about 1:1.

Abstract: The present invention is in the field of rinse-off conditioner compositions; in particular, relates to rinse-off conditioner compositions for hair frizz reduction. Deposition of conditioning materials onto the hair surface results in hair having a greasy feel and look which is undesired. Therefore, there still exists the opportunity to increase the conditioning benefits delivered through hair care compositions, preferably without hair having to look and feel greasy. It is therefore the object of the present invention to provide a conditioning product with superior frizz control even after multiple washes and which does not make the hair look and feel greasy. It has been found that a conditioner composition providing superior frizz control can be obtained using a specific combination of silicones and a tricarboxylic acid.

Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan ?) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.

Abstract: The invention discloses transparent cleansing compositions for personal care which are based on one or more vegetable oils, potassium N-acyl L-prolinate as an anionic surfactant and polyglyceryl-3 oleate as a non-ionic surfactant. The personal care cleansing formulae disclosed herein are totally based on bio-renewable ingredients. Further, in contrast to the compositions from the prior arts, the cleansing compositions of the present invention are free from toxic and petrochemical based ingredients or impurities.