Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.
Type:
Grant
Filed:
December 10, 2012
Date of Patent:
October 2, 2018
Assignee:
President and Fellows of Harvard College
Inventors:
Donald E. Ingber, Kevin Kit Parker, Geraldine A. Hamilton, Anthony Bahinski
Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.
Type:
Grant
Filed:
November 11, 2014
Date of Patent:
June 26, 2018
Assignees:
GENMARK DIAGNOSTICS, INC., ADVANCED LIQUID LOGIC, INC.
Inventors:
Jon Faiz Kayyem, Sean Ford, Vamsee K. Pamula, Vijay Srinivasan, Scott Corey, Brian Murphy, David Walter Wright, Dominic Aiello