Patents Examined by Lyle Alexander
  • Patent number: 11204342
    Abstract: A reference sample for analysis that is optimal for calibration of a pyrolysis gas chromatograph-mass spectrometer and with which precise calibration is always possible by preventing a reference substance from evaporating is provided. A reference sample sheet 1 is provided by distributing a target component or target components with a uniform normality in a base made of a high polymer material, and the reference sample sheet 1 is rolled up so that the target component or target components can be prevented from evaporating from the reference sample sheet 1 even in the case where a component has volatility. A reference sample for calibration of a pyrolysis gas chromatograph-mass spectrometer can be easily, quickly, and efficiently collected by punching out the reference sample sheet 1 using a micro-puncher 2.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: December 21, 2021
    Inventors: Fumitaka Maruyama, Shigehiko Fujimaki
  • Patent number: 11181522
    Abstract: Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: November 23, 2021
    Inventors: Zhiliang Wan, Nan Zhang
  • Patent number: 11169141
    Abstract: The invention relates to a method of detecting a clot in a measurement chamber of a liquid sample analyzer, wherein the liquid sample analyzer comprises at least two analyte sensors, a first analyte sensor, for measuring a first analyte in a liquid sample, and one or more second analyte sensors, for measuring one or more second analytes in the liquid sample in the measurement chamber, the method comprising the steps of, (a) at least partly filling the measurement chamber with a known solution having a composition comprising the first analyte at a pre-determined level, and the second one or more analytes at pre-determined levels, (b) obtaining a first sequence of measurement results by the first analyte sensor, and simultaneously obtaining a second sequence of measurement results by the second, one or more analyte sensors, (c) determining a change of the first sequence of measurement results, (d) determining a change of the second one or more sequence of measurement results, (e) comparing the change of the fir
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: November 9, 2021
    Assignee: Radiometer Medical ApS
    Inventors: Michael Taagaard, Peter Aage Frischauf, Flemming Aas
  • Patent number: 11156508
    Abstract: The present invention provides improved methods that allow accurate monitoring and/or control of temperature changes in a microfluidic environment. An advantage of the present invention is that the temperature can be monitored and/or controlled at any location within a microfluidic device, especially where a preparation step, an amplification step and/or a detection step is performed. The invention further provides improved microfluidic devices for practicing the methods disclosed and claimed herein.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: October 26, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Hamed Shadpour, Sean Ford, Jorge Alberto Garces, Darren S. Gray
  • Patent number: 11141730
    Abstract: The present invention generally relates to microfluidics, and, in particular, to systems and methods for coalescing or fusing droplets. In certain aspects, two or more droplets within a microfluidic channel are brought together and caused to coalesce without using electric fields or charges. For example, in certain embodiments, droplets stabilized with a surfactant may be disrupted, e.g., by exposing the droplets to a solvent able to alter the surfactant, which may partially destabilize the droplets and allow them to coalesce. In some instances, the droplets may also be physically disrupted to facilitate coalesce. In addition, in some cases, the positions of one or more droplets may be controlled within a channel using a groove in a wall of the channel. For example, a droplet may at least partially enter the groove such that the position of the droplet is at least partially controlled by the groove.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: October 12, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Weitz, Thomas E. Kodger, Donald Aubrecht, Ilke Akartuna
  • Patent number: 11137389
    Abstract: Methods are provided for correcting an analyte concentration measurement that may be influenced by hematocrit (HCT), especially a glucose concentration measurement. The methods include determining by means of a reference instrument a HCT reference value of a reference blood sample taken from a specific user, applying a fresh blood sample of the user on a disposable analytical test element, measuring the glucose value of the fresh blood sample by single use of the test element in a glucose meter, determining a HCT correction value using at least the HCT reference value, and adjusting the measured glucose value using the HCT correction value to receive an adjusted glucose value. Also provided are devices and system incorporating or for performing the methods.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: October 5, 2021
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Jochen Schulat, Sebastian Trick
  • Patent number: 11135582
    Abstract: The invention relates to a cartridge of a fluidic device. The fluidic device includes a fluidic chip, a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates.
    Type: Grant
    Filed: February 18, 2021
    Date of Patent: October 5, 2021
    Inventors: David K. Schaffer, Dmitry A. Markov, Ronald S. Reiserer, Lisa McCawley, Michael Geuy, Clayton M. Britt, John P. Wikswo
  • Patent number: 11131608
    Abstract: A target analyte is extracted out of a sample fluid in a sample fluid passage by diffusing the target analyte through a supported liquid membrane to a product fluid passage. Extraction of the target analyte is accelerated by applying an electric field across and perpendicular to the supported liquid membrane with electrodes. Passage of selected ions across an exchange membrane extending between one of the electrodes and the supported liquid membrane is inhibited.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: September 28, 2021
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Viktor Shkolnikov, Anita Rogacs
  • Patent number: 11124522
    Abstract: A palladium selective chemosensor based on a fluorescein-allyloxy benzene scaffold and a method of detecting palladium ions in a fluid sample with the chemosensor, whereby the fluid sample is contacted with a solution that includes water and the chemosensor to form a mixture. An ultraviolet visible absorption profile and/or a fluorescence emission profile of the mixture is measured to determine a presence or absence of palladium ions in the fluid sample, wherein the chemosensor has an ultraviolet visible absorption peak at 315 to 325 nm and a fluorescence emissions peak at 380 to 400 nm in the solution, and wherein a bathochromic shift in the ultraviolet visible absorption peak to 338 to 342 nm in the mixture and/or a bathochromic shift in the fluorescence emissions peak to 530 to 550 nm in the mixture indicates the presence of palladium ions in the fluid sample.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: September 21, 2021
    Assignee: King Fahd University of Petroleum and Minerals
    Inventor: Aasif Helal
  • Patent number: 11097269
    Abstract: A microfluidic device includes: a base plate allowing an electromagnetic wave to pass therethrough and having no autofluorescence; a microwell array formed on the base plate and including a wall layer in which a plurality of through-holes are formed in a thickness direction; and a lid member disposed opposite to the base plate in a state of being separated from the wall layer, wherein microwells are formed by the base plate and the through-holes formed in the wall layer, and wherein the wall layer is formed of a material containing a colored component that absorbs an electromagnetic wave of a predetermined wavelength.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: August 24, 2021
    Inventors: Keisuke Goto, Yoichi Makino, Akihiro Hoshino
  • Patent number: 11097268
    Abstract: A device includes a microfluidic channel structure on a substrate with a first fluid actuator and a second fluid actuator within the microfluidic channel structure. One of the fluid actuators is selectively employable to at least partially reverse fluid flow within at least a portion of the microfluidic channel structure in response to a blockage or to prevent a blockage.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: August 24, 2021
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Jeremy Sells, Nick McGuinness, Chantelle Domingue, Manish Giri
  • Patent number: 11092549
    Abstract: Described are compounds and methods useful in measuring membrane permeability and efflux transporter activity in bacteria, including multidrug resistance Gram negative bacteria.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: August 17, 2021
    Assignees: Saint Louis University, The Board of Regents of the University of Oklahoma
    Inventors: John K. Walker, Keith Haynes, Narges Abdali, Valentin V. Rybenkov, Helen I. Zgurskaya
  • Patent number: 11092577
    Abstract: The present disclosure relates to the determination of pesticides, e.g., polar pesticides, in a sample using chromatography. The present disclosure can provide direct analysis of polar pesticides, including anionic polar pesticides, using high performance liquid chromatography. The polar pesticides are sufficiently retained and resolved to allow for multiple polar pesticide determinations in a single analysis.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: August 17, 2021
    Inventors: Dimple D. Shah, Jacob N. Fairchild, Euan Ross, Benjamin Wuyts
  • Patent number: 11079325
    Abstract: This invention relates to an optical system and method for performing turbidity assay, e.g. coagulation of blood or plasma, comprising a standard optical reference, a sample handling structure, a light source and an optical detection unit. The standard optical reference, such as a fluorophore-doped glass, provides constant optical signal under controlled optical conditions. The sample handling structure, such as a microfluidic system with reaction chamber, can be placed beneath or above the standard optical reference. During operation, the coagulating plasma/blood changes its optical absorbance and reflection properties, which results in changes in optical signal that reaches the optical reading unit. The variation of the optical signal, such as fluorescence signal indicates the kinetics of the turbidity varying process, such as plasma/blood coagulation process.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: August 3, 2021
    Inventors: Josef Kerimo, Hansong Zeng, Ron Scharlack, Gert Blankenstein
  • Patent number: 11073522
    Abstract: The structures of very long chain dicarboxylic acids from blood samples may be validated through chemical derivatization of the dicarboxylic functionality with 2-picolylamine before positive ESI mass spectroscopy analysis. Laboratory standards may be used to quantify the concentration of the selected very long chain dicarboxylic acid in a blood sample.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: July 27, 2021
    Assignee: Lincoln Memorial University
    Inventor: Paul L. Wood
  • Patent number: 11065617
    Abstract: A flow passage design for multi-reaction biological detection includes a first temporary tank, a second temporary tank, a first microchannel, and a second microchannel. The first temporary tank is configured to temporarily store a first liquid in an initial state. The second temporary tank is configured to temporarily store a second liquid in the initial state. The first microchannel is located upstream of the first temporary tank. The first microchannel has an outlet end and an inlet end, respectively connecting to the first temporary tank and the second temporary tank. The second microchannel is located downstream of the first temporary tank and connects to the first temporary tank. In the initial state, a portion of the first liquid enters the second microchannel, the outlet end of the first microchannel is covered by the first liquid, and the inlet end of the first microchannel is covered by the second liquid.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: July 20, 2021
    Inventors: Chia-Chun Wei, Hung-Wei Chen, Ping-Hsing Ho
  • Patent number: 11059040
    Abstract: Transport of a vaporizable liquid containing at least one solute through a material containing nanochannels is performed by contacting material with at least one vaporizable liquid component and inducing liquid transport along nanochannel interior wall surfaces, wherein the material contains nanochannels having an average diameter up to about 300 nm, preferably up to about 100 nm, and liquid transport is induced by partial liquid vaporization. A film of solid material is deposited onto an interior nanochannel wall surface by removing the transport liquid.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: July 13, 2021
    Inventors: Sankar Sambasivan, Francis R Chapman, Jeffrey W. Donelan, Christopher J. Garcia
  • Patent number: 11047838
    Abstract: The invention relates to a method for elemental analysis, in particular for determining carbon and nitrogen in a sample, an apparatus suitable for said method, and the use of a catalyst suitable for said method, the catalyst being a metal oxide catalyst comprising oxides of Ce, Cu and Mn.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: June 29, 2021
    Inventors: Werner Küppers, Jan Macke
  • Patent number: 11041812
    Abstract: The present disclosure relates to a fluorogenic pH-sensitive dye and a film for detecting pH using the fluorogenic pH-sensitive dye on a polymer film. The fluorogenic pH-sensitive dye includes an aryl compound having a sulfonyl group (—SO2) and an agarose compound covalently bonded to the sulfonyl group (—SO2) of the aryl compound.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: June 22, 2021
    Assignee: SFC CO., LTD.
    Inventors: Moon-Chan Hwang, Jong-Tae Je
  • Patent number: 11037772
    Abstract: The invention generally relates to methods for analyzing a tissue sample. In certain aspects, the invention provides methods that involve obtaining a tissue sample including an unsaturated compound, conducting a radical reaction on the tissue sample that targets a carbon-carbon double bond within the unsaturated compound to thereby produce a plurality of compound isomers, subjecting the plurality of compound isomers to mass spectrometry analysis to identify a location of the carbon-carbon double bond within the unsaturated compound, and quantifying the plurality of compound isomers in order to distinguish normal tissue from diseased tissue.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: June 15, 2021
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Yu Xia, Xiaoxiao Ma