Patents Examined by Lyle Alexander
  • Patent number: 10888859
    Abstract: Provided in part herein are multiple-tube devices that contain a region of reduced wall thickness, which devices facilitate biological fluid processing and analysis. Also provided in part herein are methods of manufacturing and using such devices.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: January 12, 2021
    Assignee: BIOTIX, INC.
    Inventors: Arta Motadel, Peter Paul Blaszcak
  • Patent number: 10875017
    Abstract: Described is a microfluidic serial dilution platform based well-plate using an oil-free immiscible phase driven by manual or electronic pipettors. The well-plate includes a plurality of fluidic traps, a plurality of hydrophilic capillary constriction channels and a plurality of bypass channels. Each of the plurality of bypass channels is associated with one of the plurality of fluidic traps, each of the plurality of hydrophilic capillary constriction channels is associated with one of the plurality of fluidic traps, and each of the plurality of fluidic traps is associated with one of the plurality of bypass channels and one of the plurality of hydrophilic capillary constriction channels. The well-plate further includes an inlet, an outlet, and a main channel with a plurality of portions that connects the inlet to the plurality of fluidic traps, associated hydrophilic capillary constriction channels and associated bypass channels, and the outlet.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: December 29, 2020
    Assignee: NEOFLUIDICS LLC
    Inventors: Deepak Solomon, Nilesh Gupta
  • Patent number: 10864162
    Abstract: Methods for making particles, such as nanoparticles, devices useful in the methods, and particles made by the method are described herein. The methods involves the use of microfluidic device, such that upon mixing solutions of the materials to form the particles (or a solution of the material or materials to form the particles and a non-solvent for the material or materials) at least two symmetrical microvortices are formed simultaneously. The method can be used to prepare polymeric or non-polymeric particles and hybrid particles, such as lipid-polymer hybrid particles, as well as such particles containing one or more agents associated with the particles.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: December 15, 2020
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: YongTae Kim, Zahi Fayad, Willem J. Mulder, Edward Fisher, Francois Fay, Omid C. Farokhzad, Robert Langer
  • Patent number: 10859477
    Abstract: A composition for use in bioseparation. The composition includes a plurality of hollow particles having a siliceous surface. The composition further includes a surface-modifying agent bonded to the hollow particles. The surface-modifying agent includes a binding segment and a reactive segment. The binding segment includes a silyl group and the reactive segment includes a reactive nitrogen group.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: December 8, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Masayuki Nakamura, Naota Sugiyama, Cynthia D. Zook, Stephen E. Amos, Jerald K. Rasmussen, Nicole M. Gryska
  • Patent number: 10850273
    Abstract: There is provided a master for micro flow path creation, a transfer copy, and a method for producing a master for micro flow path creation by which transfer copies having an area with high hydrophilicity can be easily mass-produced, the master for micro flow path creation including: a base material; a main concave-convex portion provided on a surface of the base material and extending in a planar direction of the base material; and a fine concave-convex portion provided on a surface of the main concave-convex portion and having a narrower pitch than the main concave-convex portion. The fine concave-convex portion has an arithmetic average roughness of 10 nm to 150 nm and has a specific surface area ratio of 1.1 to 3.0.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: December 1, 2020
    Assignee: DEXERIALS CORPORATION
    Inventors: Shinya Suzuki, Kazuya Hayashibe, Akihiro Shibata
  • Patent number: 10801946
    Abstract: A method for manufacturing a device for electronically monitoring the consumption of gas adsorbent media in a media bed includes forming a monitoring rod of a corrosion resistant material. A plurality of sensors are attached to an exterior surface of the monitoring rod, and a communication channel is routed between each sensor and the connecting rod.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: October 13, 2020
    Assignee: Pure Air Filtration, LLC
    Inventor: Kevin F. Jameson
  • Patent number: 10761000
    Abstract: In a liquid stirring method, after a second liquid is discharged into a reaction container accommodating a first liquid from a dispensing probe provided with a dispensing tip at the leading end thereof, a mixture of the first liquid and second liquid in the container is stirred by being sucked out and discharged by the dispensing probe. The number of stirrings through sucking out and discharging is changed according to the total volume of the first liquid and second liquid. If the total volume of the first liquid and second liquid is below a preset threshold, sucking out and discharging is repeated for a prescribed number of times.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: September 1, 2020
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Shunsuke Sasaki, Yoshihiro Yamashita
  • Patent number: 10761095
    Abstract: A microfluidic device including a serum separator, a quantum dot and antibody inlet connected to the serum separator, a quantum dot linked immunosorbent assay (QLISA) chamber connected to the serum separator, and an outlet connected to the QLISA chamber. The microfluidic device is configured to determine an amount of drug in a serum.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: September 1, 2020
    Assignee: COMSATS Institute of Information Technology
    Inventors: Madeeha Chaudhry, Malik Abdul Rehman, Raheel Qamar, Arshad Saleem Bhatti
  • Patent number: 10753853
    Abstract: A method of evaluating the corrosion resistance of a coated metal substrate, the method including putting a liquid composition into contact with a corrosion protection coating present on the surface of a metal substrate, the liquid composition including water, a gelling agent, corrosion-catalyst ions, and a color pH indicator; gelling the liquid composition in order to form a corrosion-accelerator gel in contact with the coating; performing a corrosion test during which the gel that has formed is left in contact with the corrosion protection coating; and evaluating the corrosion resistance of the substrate coated by the corrosion protection coating by observing the color of the color pH indicator present in the gel after performing the corrosion test.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: August 25, 2020
    Assignees: ARIANEGROUP SAS, SAFRAN HELICOPTER ENGINES
    Inventors: Marie Betaille-Francoual, Loïc Oger, Anaïs Lecaplain
  • Patent number: 10710075
    Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: July 14, 2020
    Assignee: QUANTUMDX GROUP LIMITED
    Inventors: Jonathan O'Halloran, Heather Murton, Stephen Osborne, Eduardo Boada, Jonathan Salmon
  • Patent number: 10695761
    Abstract: A microfluidic system is configured for enhanced temperature control by combining spatial and temporal temperature control. The microfluidic system includes an electro-wetting on dielectric (EWOD) device comprising an element array configured to receive one or more liquid droplets, the element array comprising a plurality of individual array elements; a control system configured to control actuation voltages applied to the element array to perform manipulation operations of the liquid droplets; and a plurality of thermal control elements located at different spatial locations along the EWOD device, at least one of the thermal control elements being variable in temperature with respect to time. The control system includes a thermal control unit configured to control temperatures of the thermal control elements to generate a plurality of thermal zones located at different spatial locations along the EWOD device, at least one of the thermal zones being variable in temperature with respect to time.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: June 30, 2020
    Assignee: Sharp Life Science (EU) Limited
    Inventors: Sally Anderson, Pamela Ann Dothie, Philip Mark Shryane Roberts
  • Patent number: 10688489
    Abstract: Fluid storage containers and analysis cartridges for use in assay processes are presented. In addition, systems comprising such storage containers and analysis cartridges and methods of using such containers and cartridges are presented as well. In specific embodiments, fluid storage containers are configured to be coupled to analysis cartridges in a first stage and a second stage.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: June 23, 2020
    Assignee: LUMINEX CORPORATION
    Inventors: Ross Johnson, Chuck Collins
  • Patent number: 10663420
    Abstract: The present invention is directed to a sensor having continuous and discontinuous regions of conductive metallic nanoparticles capped with an organic coating which enables the detection of volatile organic compounds and/or water vapor. Continuous regions may exhibit a positive response upon exposure to volatile organic compounds and to water vapor, while discontinuous regions exhibit a negative response upon exposure to water vapor larger than the positive response of the continuous region.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: May 26, 2020
    Assignee: Technion R&D Foundation Ltd.
    Inventors: Hossam Haick, Meital Segev-Bar, Gregory Shuster, Sagi Gliksman
  • Patent number: 10639631
    Abstract: Microfluidic probe head for processing a sequence of separate liquid volumes separated by spacers. The microfluidic probe head includes: an inlet, an outlet, a first fluid channel and a second fluid channel and a fluid bypass connecting the first fluid channel and the second fluid channel. The first fluid channel delivers the sequence of separate liquid volumes from the inlet toward a deposition area, the fluid bypass allows the spacers to be removed from the first fluid channel obtaining a free sequence of separate liquid volumes without spacers, the first fluid channel delivers the free sequence of separate liquid volumes to the deposition area, and the second fluid channel delivers the removed spacers from the fluid bypass to the outlet. The present invention also provides a microfluidic probe and method for processing a sequence of separate liquid volumes.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: May 5, 2020
    Assignee: International Business Machines Corporation
    Inventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Xander Frank Van Kooten
  • Patent number: 10639626
    Abstract: Provided in part herein are multiple-tube devices that contain a region of reduced wall thickness, which devices facilitate biological fluid processing and analysis. Also provided in part herein are methods of manufacturing and using such devices.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: May 5, 2020
    Assignee: BIOTIX, INC.
    Inventors: Arta Motadel, Peter Paul Blaszcak
  • Patent number: 10633586
    Abstract: Polydentate polycyclic compounds of various formulas are disclosed herein. The compounds are useful for ratiometric luminescence. Significantly, the compounds will luminesce at different wavelengths/colors, depending on the analyte (metal ion, acid, or boron-containing compound) it is combined with. Thus, a single compound can provide different luminescent outputs based on the analyte, rather than requiring an entire set of structurally different compounds to detect each analyte or to generate a desired color output.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: April 28, 2020
    Inventor: Andres Zavaleta Fernandez de Cordova
  • Patent number: 10634656
    Abstract: A standard for testing measurement systems for aqueous chlorine species analysis includes an openable storage vessel and an aqueous composition including a compound having the formula R1R2NCl where R1 and R2 are independently methyl, ethyl or propyl, wherein the aqueous composition is storage stable within the openable storage vessel.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: April 28, 2020
    Assignee: HACH COMPANY
    Inventor: Darren MacFarland
  • Patent number: 10598676
    Abstract: Methods are described for determining the amount of metabolites of leflunomide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying teriflunomide in a sample.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: March 24, 2020
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Karin O. Thomassian
  • Patent number: 10585079
    Abstract: An object of the present technology is to provide a chlorine-concentration-measuring composition that can reduce staining by reagents, a measurement method using the chlorine-concentration-measuring composition and a method for reducing staining by chlorine-concentration-measuring composition using an aromatic sulfonic acid-based polymer or the salt thereof. Provided are a chlorine-concentration-measuring composition comprising an aromatic sulfonic acid-based polymer or the salt thereof; a chlorine-concentration-measuring composition comprising component (a) a color reagent for detection of residual chlorine and component (b) an aromatic sulfonic acid-based polymer or the salt thereof; a chlorine-concentration-measuring method comprising using the composition; and a method for reducing or preventing staining by using the chlorine-concentration-measuring composition comprising an aromatic sulfonic acid-based polymer or the salt thereof.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: March 10, 2020
    Assignee: KURITA WATER INDUSTRIES LTD.
    Inventor: Junichi Takahashi
  • Patent number: 10562026
    Abstract: A device, especially a microfluidic device for performance of an immunoassay, has a first, a second and a third fluidically connected chamber and a membrane. In the event of a given deflection of the membrane into the first chamber, a first fluid is passed at least partly out of the first chamber into the second chamber in such a way that a second fluid is at least partly displaced from the second chamber into the third chamber in such a way that the third chamber is entirely filled with the second fluid.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: February 18, 2020
    Assignee: Robert Bosch GmbH
    Inventors: Thomas Brettschneider, Christian Dorrer