Patents Examined by Lyle Alfandary-Alexander
  • Patent number: 6979571
    Abstract: A test strip platform for a testing apparatus of the type using test strips, wherein the platform has a shroud defining a strip track for positioning an inserted strip over an optical aperture for making analytical determinations. The platform has a hood permanently mounted to the shroud for overlying the optical window and protecting the testing apparatus optics. The strip track has stabilizing members for holding the strip in testing position. The hood provides camming members for guiding the leading edge of an inserted strip into cooperative engagement with the stabilizing members for ensuring proper insertion of the strip.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: December 27, 2005
    Assignee: Home Diagnostics, Inc.
    Inventors: Brent Modzelewski, George Rounds
  • Patent number: 6737024
    Abstract: The invention relates to solid supports for analytical measurement methods which are essentially composed of an inert solid support material on which hydrophilic measurement zones, separated from one another by a hydrophobic coating, where at least 10 measurement points are applied to the support per cm2. The invention furthermore relates to a process for producing the supports, and to the use of the supports in diagnostic methods, in research looking for active substances, in combinatorial chemistry, in crop protection, in toxicology or in environmental protection.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: May 18, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Heinz Eipel, Harald Keller
  • Patent number: 6299838
    Abstract: A test apparatus for assaying a component in a liquid sample by measuring a reflected light, comprising a support having a through hole or a light permeable area, a reagent layer having a detecting area fixed on the support to cover said through hole or light permeable area, and a cover which covers at least the detecting area, wherein at least a portion of the cover covering the detecting area is of a color which substantially has no influence on the reflected light at a measured wavelength.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: October 9, 2001
    Assignee: Kyoto Daiichi Kagaku Co., Ltd.
    Inventors: Kouji Hirayama, Michio Naka
  • Patent number: 5846485
    Abstract: A composition suitable for use in an ECL assay wherein electromagnetic radiation emitted by said composition is detected, which composition comprises (a) a metal-containing ECL moiety which, when oxidized by exposure to an effective amount of electrochemical energy, is capable of being converted to an excited state from which electromagnetic radiation is emitted upon exposure of the excited ECL moiety to conditions sufficient to induce said emission; (b) an amine or amine moiety which, when oxidized by exposure to an effective amount of electrochemical energy, forms a strong reducing agent in said composition; and (c) an electrolyte capable of functioning as a medium in which said ECL moiety and said amine or amine moiety can be oxidized by exposure to electrochemical energy.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 8, 1998
    Assignee: IGEN International Inc.
    Inventors: Jonathan Kent Leland, Michael Joseph Powell
  • Patent number: 5110746
    Abstract: Serum is reacted with a dinitrohalobenzene compound and the rate of halogen formation is measured. This rate is in proportion to the amount of albumin in the sample. Other proteins like the globulins, as well as free aminoacids and urea, do not interfere with this reaction.
    Type: Grant
    Filed: December 22, 1988
    Date of Patent: May 5, 1992
    Assignee: Pharmacia Diagnostics Inc.
    Inventors: Howard Grey, Ciaran Mangan, Jean Brochot, Iqbal Siddiqi
  • Patent number: 5104618
    Abstract: There is disclosed a net antifouling composition for use on nettings and comprised of a chloro isophthalic acid derivative, a 2(thiocyano methylthio) benzothiazole derivative, 4,5 dichloro-2-N-octyl, 4 isophthiozione-3-one, 3-iodo-2-propynyl butyl carbomate, (3-3,4 dichlorophenyl) 1,1 dimethyl urea and mixtures thereof in a water base system for controlling algae and marine organism growth on submerged netting for use in free flowing sea and/or fresh water.
    Type: Grant
    Filed: January 20, 1988
    Date of Patent: April 14, 1992
    Inventor: Richard J. Guglielmo, Sr.
  • Patent number: 5084395
    Abstract: The invention relates to a composition useful in determining an analyte in a sample. The composition contains an indicator system which forms a detectable signal in the presence of said analyte, and which is not a coupling system, as well as a pyrogallol derivative. The pyrogallol derivative causes uniform formation of detectable signal. Also described are kits useful in determining an analyte, apparatus which incorporate the composition, and a method for determining an analyte using the composition.
    Type: Grant
    Filed: July 18, 1990
    Date of Patent: January 28, 1992
    Assignee: Boehringer Mannheim GmbH
    Inventors: Lee Bouse, Michael Phillips
  • Patent number: 5066462
    Abstract: A dry-type analytical element suitable for measuring the activity of alanine aminotransferase in a liquid sample, characterized by incorporating a dye capable of absorbing the electromagnetic waves of 400 to 500 nm into at least one water-permeable layer. The coloring sensitivity of the dry-type analytical element does not increase substantially even under a fluorescent light, and thereby, an accurate measured value can easily be obtained.
    Type: Grant
    Filed: August 29, 1989
    Date of Patent: November 19, 1991
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Kazuya Kawasaki, Mitsutoshi Tanaka, Yoshikazu Amano, Harumi Katsuyama
  • Patent number: 5055410
    Abstract: A method and diagnostic test unit for the determination of one or more non-triglycerides in an oil using an oil-miscible test solution prepared from an oil-miscible vehicle of monoglycerides, diglycerides or mixtures thereof and an indicator deliverable in admixture with the vehicle for assaying the non-triglycerides, wherein the indicator in combination with the non-triglycerides forms a reaction product characteristic of the amount of the non-triglycerides, and the indicator and vehicle are present in quantities and at a pH effective to provide detectable quantities of reaction product. The reaction product development is compared to a known standard to determine the presence or amount of the non-triglycerides in the oil.
    Type: Grant
    Filed: March 2, 1989
    Date of Patent: October 8, 1991
    Assignee: Libra Laboratories, Inc.
    Inventors: Michael M. Blumenthal, Jerry R. Stockler, Harry M. Van Tassell
  • Patent number: 5039485
    Abstract: A sterilant mixture comprising 14 to 25 mole percent ethylene oxide and 75 to 86 mole percent 1,1,2,2,2-pentafluoroethane, and a sterilization method using same.
    Type: Grant
    Filed: September 26, 1990
    Date of Patent: August 13, 1991
    Assignee: Union Carbide Industrial Gases Technology Corporation
    Inventors: Stephen A. Conviser, Claude C. Woltz, Jr.
  • Patent number: 5039484
    Abstract: A sterilant mixture comprising 15 to 30 mole percent ethylene oxide and 70 to 85 mole percent 1,1-dichloro-,2,2,2-trifluoroethane and/or 1-chloro-1,2,2,2-tetrafluoroethane, and a sterilization method using same.
    Type: Grant
    Filed: August 15, 1990
    Date of Patent: August 13, 1991
    Assignee: Union Carbide Industrial Gases Technology Corporation
    Inventors: Simon Chippett, Stephen A. Conviser
  • Patent number: 5028543
    Abstract: A method for measuring the halogenated organic compound content, e.g., polychlorinated biphenyl ("PCB") content, of soil samples may effectively be carried out with an inexpensive, disposable (that is, single-use) field test kit. The method includes contacting a weighted soil sample suspected of containing PCB or some other organohalogen contaminant with a pre-mixture of water and an organic solvent in which water is slightly soluble. The water extracts any inorganic halides which may be present and would adversely affect the accuracy of the test. The organic solvent wets the moist soil sample sufficiently to extract any PCB therein. The resultant organic solvent phase is separated from the soil sample and aqueous phase, dried by passage through a moisture-adsorbent material to remove or at least greatly reduce its moisture content, and analyzed by means of a color-change titration to determine halide content, and thereby the PCB (or other organohalogen) content, of the soil sample.
    Type: Grant
    Filed: April 4, 1990
    Date of Patent: July 2, 1991
    Assignee: Dexsil Corporation
    Inventors: Stephen R. Finch, David J. Fisher
  • Patent number: 5024816
    Abstract: Disclosed is a method for determining the degree of freshness of such raw, frozen and processed perishable foodstuffs as meat, poultry and fish and an instrument therefor. The degree of freshness can be easily determined by the method of the present invention in shorter periods of time than by the conventional methods.The method of this invention comprises determining the amount of certain decomposition products of adenosine triphosphate such as hypoxanthine, inosine and inosinic acid by measuring the consumption of dissolved oxygen while each compound is subjected to action by certain enzymes, i.e., hypoxanthine by xanthine oxidase, inosine by nucleoside phosphorylase and inosinic acid by alkaline phosphatase, nucleoside phosphorylase and xanthine oxidase.
    Type: Grant
    Filed: December 5, 1989
    Date of Patent: June 18, 1991
    Assignees: Zaidanhojin Shokuhin Sangyo Senta, Oriental Electric Company, Ltd.
    Inventors: Kei Arai, Minoru Ohashi, Yoshio Utsugi, Osamu Oka, Kenichi Numazawa, Kenji Miwa, Kenzo Sugawara
  • Patent number: 5021221
    Abstract: Vaporized silicon halide is mixed with a vaporized alkali metala in a reactor chamber in an exothermic reaction producing liquid silicon droplets and gaseous alkali metal halide, and then passed out of the reactor chamber through a nozzle in a supersonic jet. The supersonic jet is produced by utilizing vacuum means to maintain the exit chamber at a lower pressure than the reactor chamber. Separation of the silicon from the salt by-products is performed by shock wave impaction separation technique wherein the products of the complete reaction between the alkali metal and silicon halide are made to impinge upon an unrestricted, flat surface so that the direction of flow of the gas changes abruptly and a shock zone is created above the flat surface. The silicon droplets are carried by their large forward momentum through the shock zone onto the separating surface where they are deposited. The gaseous alkali metal halide flows across the surface and is thus separated from the silicon product.
    Type: Grant
    Filed: December 4, 1986
    Date of Patent: June 4, 1991
    Assignee: Aero Chem Research Lab., Inc.
    Inventors: Robert K. Gould, Charles R. Dickson
  • Patent number: 5017498
    Abstract: The present invention is related to compounds of the general formula (I) ##STR1## wherein R.sup.1 denotes hydrogen, halogen or C.sub.1 -C.sub.4 alkyl andR.sup.2 denotes C.sub.1 -C.sub.4 alkyl, aryl or heteroaryl, or a substituted C.sub.1 -C.sub.4 alkyl, aryl or heteroaryl and their preparation. The compounds can be used in an iron assay system.
    Type: Grant
    Filed: March 1, 1989
    Date of Patent: May 21, 1991
    Assignee: Miles Inc.
    Inventors: Piero Fossati, Holger Heidenreich, Herbert Hugl, Klaus Wehling
  • Patent number: 5013527
    Abstract: In an integral multilayer analytical element for the analysis of albumin where at least one hydrophilic polymer binder layer and a porous spreading layer containing an indicator capable of binding to albumin to produce a color change are integrally superposed on a light-transmissive water-impermeable support in this order, the improvement comprising said indicator being dispersed in a hydrophilic polymer or a mixture of a hydrophilic polymer and a hydrophobic polymer and a pH buffer being incorporated into the spreading layer.
    Type: Grant
    Filed: August 19, 1988
    Date of Patent: May 7, 1991
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Fuminori Arai, Takeshi Takayama
  • Patent number: 5011779
    Abstract: The disclosure is directed to a method and apparatus for depositing a plurality of discrete liquid assay test samples onto an absorbent assay support. Pursuant to the invention, a guide and positioning device is provided to receive and position a device for dispensing a plurality of discrete test samples such that the dispensing device is operable to dispense the plurality of test samples in accordance with a predetermined pattern. A planar absorbent assay support device is positioned at a position which is vertically spaced and aligned below the guide and positioning device to receive the discrete test samples dispensed by the dispensing device. In this manner, a plurality of discrete test sample spots may be rapidly absorbed onto the absorbent assay support device in accordance with the predetermined pattern for efficient, simultaneous processing in a chosen immunoassay system.
    Type: Grant
    Filed: October 2, 1989
    Date of Patent: April 30, 1991
    Assignee: Long Island Jewish Medical Center
    Inventor: Jonathan Maimon
  • Patent number: 5009847
    Abstract: A kit is provided for measuring chemical and physical stresses on the blood platelets of a human patient by measuring reduction in ATP (adenosine triphosphate) and ADP (adenosine diphosphate) concentrations while measuring increases in the ATP degradation products HYPX (hypoxanthine) and the AMP (adenosine monophosphate). The kit is useful for measuring a human patient's risk to internal stress such as reduction in the size of blood vessels, to response to various environmental changes as well as to a variety of treatments including drug treatment, risk of malignant hyperthermia in response to anesthetic administration or in response to vascular or organ transplant.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: April 23, 1991
    Inventor: Clive C. Solomons
  • Patent number: 5008078
    Abstract: A multi-layer analysis element including an endogenous ammonia trapping layer, an ammonia producing layer containing a composition capable of reacting with an ammonia producing substance to produce gaseous ammonia, and at least one layer essentially incapable of trapping ammonia and essentially incapable of producing ammonia, and capable of preventing the diffusion of ammonia, disposed between the endogenous ammonia trapping layer and the ammonia producing layer. The unified multi-layer analysis element according to the invention is useful for the quantitative analysis of ammonia producing substances in aqueous biological food samples, with a high degree of sensitivity and accuracy, using a simple procedure.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: April 16, 1991
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Nakatsugu Yaginuma, Takaki Arai
  • Patent number: 5002736
    Abstract: Two rectangular slides having front and rear faces are held with front faces facing each other. Raised end portions on one or both front faces abut and space the front faces by a distance (e.g., 100 to 250 .mu.m) conducive for reversible capillary action between the slides. Raised island portions on one or both front faces are located at corners opposite the raised end portions. The raised island portions serve to maintain spacing between the front faces, particularly as the ends of the slides opposite to the raised end portions contact an absorbent material. An opening between the raised island portions permits liquid to enter and leave the gap between the front faces.
    Type: Grant
    Filed: October 26, 1987
    Date of Patent: March 26, 1991
    Assignees: Fisher Scientific Co., Erie Scientific Co.
    Inventors: Thomas J. Babbitt, David J. Brigati