Patents Examined by Lynette R. F. Smith
  • Patent number: 7183108
    Abstract: The invention concerns lactic acid bacteria strains capable of regulating the production of NO and inflammatory cytokines by enterocytes, depending on the inflammatory condition of said enterocytes. The strains can also be incorporated in food supplements such as fermented dairy products used for regulating inflammatory response and non-specific immunity.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: February 27, 2007
    Assignee: Compagnie Gervais Danone
    Inventors: Chantal Cayuela, Nathalie Dugas, Eric Postaire
  • Patent number: 7179473
    Abstract: This invention relates to attenuated pestiviruses characterised in that their enzymatic activity residing in glycoprotein ERNS is inactivated, methods of preparing, using and detecting these.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: February 20, 2007
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventor: Gregor Meyers
  • Patent number: 7169903
    Abstract: The present invention encompasses protective monoclonal antibodies that bind to peptidoglycan of Gram-positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and block nasal colonization by Gram-positive bacteria in vivo. The invention also provides human, humanized and chimeric antibodies. The invention also sets forth the heavy chain and light chain variable regions of an antibody within the invention.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: January 30, 2007
    Assignee: Biosynexus Incorporated
    Inventors: Richard F. Schuman, John Fitzgerald Kokai-Kun, Simon J. Foster, Jeffrey R. Stinson, Gerald Walter Fischer
  • Patent number: 7166290
    Abstract: The present invention provides improved methods and compositions for producing oocysts. The oocysts produced according to the invention find use in the manufacture of vaccines. In preferred embodiments, the present invention provides methods and compositions for the production of Eimeria oocysts. Vaccines containing Eimeria oocysts, sporocysts and/or sporozoites produced according to the present invention may be used to immunize birds against coccidiosis either in ovo or post hatch.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: January 23, 2007
    Assignee: Embrex, inc.
    Inventors: James E. Hutchins, Julius K. Tyczkowski
  • Patent number: 7163810
    Abstract: In a method for producing a target substance by using a microorganism comprising culturing a microorganism having an ability to produce the target substance in a medium to produce and accumulate the target substance in the medium or cells of the microorganism and collecting the target substance from the medium or the cells of the microorganism, there are used, as the microorganism, a microorganism to which a methanol dehydrogenase gene is introduced, of which activities of hexulose phosphate synthase and phosphohexuloisomerase are enhanced and which is modified so that an ability to utilize methanol should be imparted or enhanced, and there is used a medium containing methanol as a carbon source.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: January 16, 2007
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hisashi Yasueda, Ryo Takeshita
  • Patent number: 7157234
    Abstract: A microscale binding assay, analyte binding array, and kits are disclosed, which exploit the mass action law to harvest analyte from a liquid sample. This is achieved by fabrication of sorbent zones having up to ten times the binding capacity per unit area generally obtained on polystyrene microtiter plates. The resulting arrays substantially deplete the liquid solution of analyte during incubation. Accordingly, the assays respond to total mass of analyte in the sample, not analyte concentration. This approach, coupled with direct fluorescence detection in the NIR, yields maximal signal intensity and low background for optimal sensitivity.
    Type: Grant
    Filed: April 21, 1998
    Date of Patent: January 2, 2007
    Assignee: Beckman Coulter, Inc.
    Inventors: Robert J. Obremski, John W. Silzel, Tsong-Tseh Tsay, Bibijana Cercek, Charles L. Dodson, Tung Rung Wang, Yagang Liu, Zhou Shaomin
  • Patent number: 7153952
    Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: December 26, 2006
    Assignee: sanofi pasteur limited/sanofi pasteur limitée
    Inventors: Lynn Doucette-Stamm, David Bush, Qiandong Zeng, Timothy Opperman, Chad Eric Houseweart
  • Patent number: 7144998
    Abstract: Recombinant polypeptides are prepared using novel nucleic acids with transcription promoter activity. The recombinant cells containing said nucleic acids are described. A novel method for preparing antigens or antigen fragments, in particular bacterial toxins, preferably Clostridum toxins, for preparing immunogenic and/or vaccine compositions is also described.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: December 5, 2006
    Assignee: Institut Pasteur
    Inventors: Maryse Gibert, Michel-Robert Popoff
  • Patent number: 7135298
    Abstract: The present invention provides an assay for the identification of agents which can modulate TOR-mediated phosphorylation of substrate proteins. The assays of the invention utilize substrate proteins whose amino acid sequence contains the Ser/Thr motif recognized by TOR. Naturally occurring TOR which may be used in the methods of the invention include TOR isolated from a variety of species, particularly mammalian tissues.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: November 14, 2006
    Assignee: The Burnham Institute for Medical Research
    Inventor: Robert T. Abraham
  • Patent number: 7135191
    Abstract: The invention is directed to a suppository based vaccine delivery system for immunizing against urogenital and anorectally transmitted infectious disease in humans and animals and a method for treating the same. More particularly, this invention is directed to a suppository based vaccine delivery system for the prophylaxis against or treatment of urogenital or anorectal transmitted infectious diseases, such as from viral or microbial pathogens.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: November 14, 2006
    Inventors: Zsolt Istvan Hertelendy, Murray Weiner, Michael Howell, Joseph Thomas
  • Patent number: 7135560
    Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: November 14, 2006
    Assignee: sanofi pasteur limited
    Inventors: Lynn Doucette-Stamm, David Bush, Qiandong Zeng, Timothy Opperman, Chad Eric Houseweart
  • Patent number: 7129340
    Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: October 31, 2006
    Assignee: sanofi pasteur limited/sanofi pasteur limitée
    Inventors: Lynn Doucette-Stamm, David Bush, Qiandong Zeng, Timothy Opperman, Chad Eric Houseweart
  • Patent number: 7129339
    Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: October 31, 2006
    Assignee: sanofi pasteur limited
    Inventors: Lynn Doucette-Stamm, David Bush, Qiandong Zeng, Timothy Opperman, Chad Eric Houseweart
  • Patent number: 7128918
    Abstract: Streptococcus proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of producing the protein antigens as well as diagnostic assays for detecting streptococcus bacterial infection.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: October 31, 2006
    Assignee: ID Biomedical Corporation
    Inventors: Josee Hamel, Bernard R. Brodeur, Isabelle Pineau, Denis Martin, Clement Rioux, Nathalie Charland
  • Patent number: 7125696
    Abstract: A invention concerns a novel method for preparing a polypeptide soluble in an aqueous solvent in the absence of detergent, and polypeptides obtainable by said method. The invention also concerns the use of said polypeptides, in particular for preparing medicines or vaccines, for fighting against bacterial and viral infections or cancers.
    Type: Grant
    Filed: January 4, 2001
    Date of Patent: October 24, 2006
    Assignee: Pierre Fabre Medicament
    Inventors: Thierry Baussant, Pascale Jeannin, Yves Delneste, François Lawny, Jean-Yves Bonnefoy
  • Patent number: 7122370
    Abstract: Disclosed is a formulation for preserving the life of probiotic bacteria during passage through the stomach, while permitting their release in the intestine, and which has a low water activity and correspondingly long shelf life. These formulations are designed to retain potency up to the product expiration date. The formulation includes a substantially water-free mixture of probiotic bacteria with monovalent alginate salts, wherein the mixture has been formed and is maintained in a substantially water-free environment. The alginate salts include sodium alginate and potassium alginate, but not divalent salts such as magnesium alginate or calcium alginate. Generally, an enteric coating (e.g., gelatin or cellulose encapsulation) for the formulation is provided.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: October 17, 2006
    Inventor: Randolph Stanley Porubcan
  • Patent number: 7122197
    Abstract: The invention provides BASB020 polypeptides and polynucleotides encoding BASB020 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: October 17, 2006
    Assignee: SmithKline Beecham Biologicals S.A.
    Inventor: Joelle Thonnard
  • Patent number: 7115731
    Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: October 3, 2006
    Assignee: sanofi pasteur limited/ sanofi pasteur limiteé
    Inventors: Lynn Doucette-Stamm, David Bush, Oiandong Zeng, Timothy Opperman, Chad Eric Houseweart
  • Patent number: 7115268
    Abstract: This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates to peptides derived from homologous sequences of the family of staphylococcal and streptococcal toxins, which may be polymeric, and carrier-conjugates thereof. The invention also relates to serum antibodies induced by the peptides and carrier-conjugates and their use to prevent, treat, or protect against the toxic effects of most, if not all, of the staphylococcal and streptococcal toxins. The invention also relates to diagnostic assays and kits to detect the presence of staphylococcal and streptococcal toxins, or antibodies thereto. The invention also relates isolated and purified to nucleic acids encoding the peptides of the invention and transformed host cells containing those nucleic acids.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: October 3, 2006
    Assignee: The Rockefeller University
    Inventors: Jason D. Bannan, Kumar Visvanathan, John B. Zabriskie
  • Patent number: 7101553
    Abstract: A prebiotic for enhancement of an immune response, a nutritional composition for enhancement of an immune response; use of a prebiotic in the manufacture of a medicament or nutritional composition for enhancement of an immune response; use of a prebiotic in the manufacture of a medicament or nutritional composition for the prevention or treatment of measles; a method of enhancing an immune response which comprises administering an effective amount of a prebiotic; and a method of prevention or treatment of measles which comprises administering an effective amount of a prebiotic. In preferred embodiments the prebiotic comprises a fructo-oligosaccharide.
    Type: Grant
    Filed: April 13, 2004
    Date of Patent: September 5, 2006
    Assignee: Nestec S.A.
    Inventors: Ferdinand Haschke, Anne-Lise Carrie, Zdenek Kratky, Harriet Link-Amster, Florence Rochat