Abstract: The present invention is directed to a method for purifying polysaccharides capable of inducing the production of high titers of opsonic antibodies that kill strains of enterococcal bacteria. In addition, the invention is directed to the antigens produced by this purification method and to vaccines which utilize such antigens.
Type:
Grant
Filed:
March 11, 2002
Date of Patent:
April 20, 2004
Assignee:
The Brigham and Women's Hospital, Inc.
Inventors:
Gerald B. Pier, Johannes Huebner, Ying Wang, Lawrence Madoff