Abstract: A photodynamic therapy (PDT) system includes an elongated interventional device with a bundle of optical fibers forming respective light exit ports which can be individually accessed. The bundle has an optical shape sensing fiber arranged for sensing position and orientation of the light exit ports. A processor is configured to generate a light dose signal to allow generation of light outputs to the optical fibers. The light dose signal is generated in response to the determined position and orientation of the light exit ports, and three-dimensional body anatomy image information obtained by a first image modality. The processor is also configured to take image information regarding distribution of a photo sensitizer in the body tissue as input, as well as take into account image information regarding a concentration of oxygen in the body tissue.

Abstract: By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon absorption, we used a two (or more)-photon-absorbing chromophore.

Abstract: The present invention provides a laser system and laser handpiece and process for skin treatment. The system includes components for producing a continuous or pulse laser beam, and components for delivering a substance to the damaged region of skin. The system is designed to control and utilize the laser beam for damaging small volume of skin tissue and using a disposable tip to deliver a substance which is applied simultaneously or with some delay producing a combination of laser action with the action of a named substance at the same time.

Abstract: Embodiments of a balloon biasing laser catheter are provided. In some embodiments, the laser catheter may include a distal tip that extends from the distal end of the catheter from a point near the light guide aperture. The distal tip may be disposed at the periphery of the catheter. In some embodiments, a balloon may be disposed between the light guide aperture and the distal tip, such that the a light guide extending from the aperture may be disposed proximate with the distal tip having the balloon in between. A retaining wire may be coupled with the distal tip and slidably coupled with the light guide. The retaining wire may keep the light guide biased relatively parallel with the distal tip and/or the catheter body when the balloon is inflated. The light guide may include a guidewire lumen the extends to the distal end of the distal tip.

Abstract: A surgical system and method includes a surgical instrument configured to wirelessly transmit identifying data specific to the surgical instrument and a console configured to receive the identifying data. The console is configured to register the surgical instrument based on the identifying data, establish a wireless two-way communication link between the surgical instrument and the console, receive at least one of operational data and commands from the surgical instrument, and provide operational feedback data to a user of the surgical instrument during an operation of the surgical instrument based on the at least one of operational data and commands.

Abstract: A method for producing a cut surface in a transparent material using optical radiation. A laser device separates the material using optical radiation and includes an optical unit focussing the radiation along an optical axis into an image field defining an image-field size. A focal position is adjusted transversely along the axis, producing a cut surface extending substantially parallel to the axis and, in projection along the axis, is a curve having a maximum extent. The focus is displaced by adjustment of the focal position along a trajectory curve lying in the cut surface. The cut surface has a maximum extent which is greater than the image-field size. The focal position is moved transverse to the axis along the curve. The image field is displaced transversely, and the focal position is adjusted in an oscillating fashion along the axis on the curve between an upper and lower axial focus position.

Abstract: Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. Wherein, when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer and the heated energy-absorbing material of the scleral shield conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region.

Abstract: A method for preparing an endothelial corneal graft is provided. The method comprises: providing a donor cornea; irradiating the donor cornea from an endothelial side thereof with laser radiation to cause a photodisruption in tissue of the donor cornea at a focal point of the radiation; and moving the focal point of the radiation to form an endothelial graft in the donor cornea. By irradiating the donor cornea from the endothelial side thereof, instead of the epithelial side, to cut the endothelial graft, optical inhomogeneities which may develop after death in stromal tissue of the donor cornea leave the laser cutting process substantially unaffected.

Abstract: An improved method and device is provided for safe and efficient low power density endoluminal treatment of venous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360° radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial directions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Additional embodiments include spacing/centering mechanisms to keep emitting end radially equidistant from vein walls. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure.

Abstract: A skin treatment device comprising a light source providing a light beam for optically treating skin, a wheel with a wheel surface for reflecting the light beam towards the skin, driving means for rotating the wheel and changing an angular position of the wheel, where different angular positions of the wheel correspond to different directions of reflection for the light beam, an angular position detector for detecting the angular position of the wheel, storage means for storing predefined skin-treatment patterns, a relation between the different angular positions of the wheel; and different reflection directions of the light beam, a control circuit coupled to the light source. The light source being controlled in dependence on the detected angular position such that, for each revolution of the wheel, the light beam is controlled to only illuminate the wheel surface in selected angular positions of the wheel to realize a predefined skin-treatment pattern.

Abstract: Aspects for treating spinal cord injuries are disclosed. In a particular aspect, a method includes identifying a neurological level of a spinal cord injury, and activating neurons via laser therapy in which a laser beam is applied to an area proximate to the neurological level. In another aspect, a computer-readable storage medium includes computer-readable instructions for performing various acts. Such acts comprise ascertaining a neurological level of a spinal cord injury, and receiving data corresponding to a severity of the spinal cord injury. The acts further comprise outputting a laser calibration according to the neurological level and the severity. A medical device apparatus is also provided, which includes various computer executable components. The computer executable components include an assessment component configured to receive parameters corresponding to a spinal cord injury, and a calibration component configured to ascertain a laser calibration according to the at least one parameter.

Abstract: Certain exemplary embodiments of the present disclosure can provide an apparatus and method for generating at least one radiation can be provided. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range can be provided.

Abstract: In one exemplary aspect, the present disclosure is directed to a system. The system includes a pneumatic surgical instrument and a surgical console operable to provide compressed gas to the pneumatic surgical instrument. Additionally, the system includes a pneumatic drive line coupling the pneumatic surgical instrument to the surgical console. The pneumatic drive line has an internal bore configured to deliver the compressed gas to the pneumatic surgical instrument. The internal bore has a non-uniform cross-section along a length of the pneumatic drive line.

Abstract: A handpiece tip includes an optical waveguide with a proximal input end for receiving electromagnetic energy and a distal output end for emitting electromagnetic energy. The tip has an eyeball engagement surface with a concave contour, and has an oppositely facing eyelid engagement surface with a convex contour. The distal output end of the waveguide is located at the eyelid engagement surface.

Abstract: A system may include a stone analyzer, a controller, a laser generator, and a beam combiner. The stone analyzer may be configured to generate an output relating to a natural or resonance frequency of a kidney or bladder stone. The controller may be configured to determine the natural or resonance frequency of the stone based on the output from the stone analyzer, and match a resultant pulse repetition rate with the natural or resonance frequency. The laser generator may be configured to generate at least two laser pulse trains, with each laser pulse train including laser pulses at a pulse repetition rate. The beam combiner may be configured to combine the at least two laser pulse trains into a combined laser pulse train including laser pulses at the resultant pulse repetition rate.

Abstract: The present application is directed towards method and systems for determining appropriate morphology changes of an eardrum to restore sensor neural hearing. The methods include receiving a measurement of an audibility threshold, a map of a surface area of an eardrum of the patient, and an impedance of the eardrum of the patient. The methods further include determining, based on at least one of the audibility threshold, the map of the surface area, and the impedance, a thickness value to modify a morphology of a portion of the eardrum of the patient to improve hearing of the patient.

Abstract: Embodiments of the present invention encompass systems and methods for customized vision treatments that account for effects associated with corneal flap creation.

Abstract: Methods and systems for performing laser-assisted surgery on an eye form a layer of bubbles in the Berger's space of the eye to increase separation between the posterior portion of the lens capsule of the eye and the anterior hyaloid surface of the eye. A laser is used to form the layer of bubbles in the Berger's space. The increased separation between the posterior portion of the lens capsule and the anterior hyaloid surface can be used to facilitate subsequent incision of the posterior portion of the lens capsule with decreased risk of compromising the anterior hyaloid surface. For example, the layer of bubbles can be formed prior to performing a capsulotomy on the posterior portion of the lens capsule.

Abstract: A neural prosthetic device can selectively deliver light to different cortical layers, at different depths, in the brain. The device includes LEDs and corresponding waveguides that can extend into the brain. At least two of the waveguides have different lengths. The neural prosthetic device or other devices can be manufactured by changing the hydrophilicity or lyophilicity of a portion of a substrate layer, then depositing uncured polymer on the treated portion of the substrate layer. The uncured polymer flows under the influence of surface tension to form a volume. The volume is shaped as a dome that extends laterally to a boundary between the treated and untreated portions. The polymer is cured in discrete regions through the substrate layer. The discrete regions extend longitudinally from the substrate layer to a curved surface of the dome. The uncured portion of the polymer is removed. The cured regions form the waveguides.

Abstract: Body tissue ablation is carried out by inserting a probe into a body of a living subject, urging the probe into contact with a tissue in the body, generating energy at a power output level, and transmitting the generated energy into the tissue via the probe. While transmitting the generated energy the ablation is further carried out by determining a measured temperature of the tissue and a measured power level of the transmitted energy, and controlling the power output level responsively to a function of the measured temperature and the measured power level. Related apparatus for carrying out the ablation is also described.