Patents Examined by M. DeCloux
  • Patent number: 6699672
    Abstract: A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: March 2, 2004
    Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedman, Tuvia Perets
  • Patent number: 6506875
    Abstract: The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: January 14, 2003
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Sacha Gnjatic, Lloyd J. Old, Yasuhiro Nagata, Elke Jager, Yao-Tseng Chen, Alexander Knuth