Abstract: A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.
Type:
Grant
Filed:
November 3, 2000
Date of Patent:
March 2, 2004
Assignees:
InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.
Inventors:
Iris Pecker, Israel Vlodavsky, Yael Friedman, Tuvia Perets
Abstract: The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.
Type:
Grant
Filed:
September 26, 2000
Date of Patent:
January 14, 2003
Assignee:
Ludwig Institute for Cancer Research
Inventors:
Sacha Gnjatic, Lloyd J. Old, Yasuhiro Nagata, Elke Jager, Yao-Tseng Chen, Alexander Knuth