Patents Examined by M Marvich
  • Ligands added to adenovirus fiber
    Patent number: 6683170
    Abstract: The fiber protein of adenovirus has been genetically altered via attachment at the carboxyl end of a peptide linker, preferably up to 26 amino acids in length which forms a random coil, which can be used to attach a non-adenovirus ligand altering the binding specificity of the fiber protein. Examples of ligands include peptides which are selectively bound by a targeted cell so that the modified fiber protein is internalized by receptor-mediated endocytosis, and peptides which can act as an universal coupling agent, for example, biotin or strepavidin. The linker is designed to not interfere with normal trimerization of fiber protein, to avoid steric hindrance of binding of the fiber protein to a targeted cell, and to serve as a site to introduce new peptide sequence.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: January 27, 2004
    Assignee: UAB Research Foundation
    Inventors: David T. Curiel, Jeffrey A. Engler
  • Dendritic cells; methods
    Patent number: 6660523
    Abstract: Dendritic cell subsets, and various methods of making and using same are provided. In particular, methods for making a defined subset of dendritic cells are provided.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: December 9, 2003
    Assignee: Schering Corporation
    Inventors: Bianca Blom, Yong-Jun Liu
  • Plant expression constructs
    Patent number: 6660911
    Abstract: The present invention relates to novel plant expression constructs. More specifically the present invention provides DNA constructs comprising 5′ regulatory sequences for modulating the expression of operably linked genes in plants.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: December 9, 2003
    Assignee: Monsanto Technology LLC
    Inventors: Karen L. Fincher, Stanislaw Flasinski, Jack Q. Wilkinson
  • Recombinant DNA method and host cells
    Patent number: 6653101
    Abstract: The present invention provides a process and host cell for use in increasing the amount of a desired protein by a cell line. The process and the cell line use a first transcription unit containing a gene for a transactivator protein to control the transactivation of a second transcription unit such that the amount of the desired protein expression can be increased without adversely affecting the cell growth. Preferred transactivator proteins are derived from EIA.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: November 25, 2003
    Assignee: Alusuisse Holdings A.G.
    Inventors: Mark Ian Cockett, Christopher Robert Bebbington, Geoffrey Thomas Yarranton
  • Naked cuticle genes and their uses
    Patent number: 6630323
    Abstract: Methods for isolating naked cuticle genes are provided. The naked cuticle nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: October 7, 2003
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Matthew Scott, Wenlin Zeng, Keith Wharton