Patents Examined by M Monshipouri
  • Sphingosine kinase enzyme
    Patent number: 6730480
    Abstract: The present invention relates generally to novel protein molecules and to derivatives, analogues, chemical equivalents and mimetics thereof capable of modulating cellular activity and, in particular, modulating cellular activity via the modulation of signal transduction. More particularly, the present invention relates to human sphingosine kinase and to derivatives, analogues, chemical equivalents and mimetics thereof. The present invention also contemplates genetic sequences encoding said protein molecules and derivatives, analogues, chemical equivalents and mimetics thereof. The molecules of the present invention are useful in a range of therapeutic, prophylactic and diagnostic application.
    Type: Grant
    Filed: January 24, 2002
    Date of Patent: May 4, 2004
    Assignee: Johnson & Johnson Pharmaceutical Research and Development LLC
    Inventors: Stuart Maxwell Pitson, Brian Wolff Wattenberg, Pu Xia, Richard James D'Andrea, Jennifer Ruth Gamble, Matthew Alexander Vadas
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6638745
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: October 28, 2003
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Kabir Chaturvedi, Valentina DiFrancesco, Ellen M. Beasley
  • UDP-N-acetylglucosamine: galactose-&bgr;1, 3-N-acetylgalactosamine-&agr;-R/(GlcNAc to GalNAc) &bgr;1,6-N-acetylglucosaminyltransferase, C2GnT3
    Patent number: 6635461
    Abstract: A novel gene defining a novel human UDP-GlcNAc: Gal&bgr;1-3 GalNAc&agr; &bgr;1,6GlcNAc-transferase, termed C2GnT3, with unique enzymatic properties is disclosed. The enzymatic activity of C2GnT3 is shown to be distinct from that of previously identified enzymes of this gene family. The invention discloses isolated DNA molecules and DNA constructs encoding C2GnT3 and derivatives thereof by way of amino acid deletion, substitution or insertion exhibiting C2GnT3 activity, as well as cloning and expression vectors including such DNA, cells transfected with the vectors, and recombinant methods for providing C2GnT3. The enzyme C2GnT3 and C2GnT3-active derivatives thereof are disclosed, in particular soluble derivatives comprising the catalytically active domain of C2GnT3.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: October 21, 2003
    Assignee: Glycozym Aps
    Inventors: Tilo Schwientek, Henrik Clausen
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6630337
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: October 7, 2003
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Herbicides test method
    Patent number: 6630331
    Abstract: An isolated DNA molecule encoding a protein from a plant, which protein has pantothenate synthetase activity; a non-naturally occuring chimeric gene comprising a promoter operably linked to a DNA molecule encoding a protein from a plant having pantothenate synthetase activity; a recombinant vector comprising the chimeric gene wherein the vector is capable of being stably transformed into host cell, a host cell stably transformed with a vector wherein the host cell is capable of expressing the DNA molecule; a method for assaying a protein having pantothenate synthetase activity; the use as herbicides of compounds which inhibit pantothenate synthetase, and a herbicidal composition, comprising one or more active ingredients which show significant pantothenate synthetase inhibition in an assay, are disclosed. The invention relates to plant enzymatic activity, and aspects therefor, involved in the biosynthesis of coenzyme A.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: October 7, 2003
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Christopher Abell, Alison Gail Smith, Ulrich Genschel, Bernd Laber
  • 14171 protein kinase, a novel human protein kinase and uses thereof
    Patent number: 6630335
    Abstract: The invention relates to a novel kinase nucleic acid sequence and protein. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: October 7, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Rosana Kapeller-Libermann
  • Human kinase proteins and polynucleotides encoding the same
    Patent number: 6617147
    Abstract: Novel human kinase polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: April 24, 2001
    Date of Patent: September 9, 2003
    Assignee: Lexicon Genetics Incorporated
    Inventors: Yi Hu, Boris Nepomnichy, Xiaoming Wang, Gregory Donoho
  • Human kinase proteins and polynucleotides encoding the same
    Patent number: 6602698
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: August 5, 2003
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, John Scoville, C. Alexander Turner, Jr., Glenn Friedrich, Brian Zambrowicz, Alejandro Abuin, Arthur T. Sands
  • Compositions and methods comprising cytostatic protein kinase
    Patent number: 6599726
    Abstract: The present invention presents a unique class of physiological suppressors of cell division and cleavage. In particular, the present invention presents p21-activated protein kinase PAK I, also known as protease activated protein kinase I (with the same abbreviation “PAK I”) which has been purified to apparent homogeneity. PAK I is inactive, e.g. as a protein of about 60 kDa (denoted “p60”, as determined by polyacrylamide gel electrophoresis) and is active when autophosphorylated, for example, following limited proteolysis, or binding of Cdc42, e.g., as a protein of about 58 kDa (denoted “p58” as determined by polyacrylamide gel electrophoresis). The present invention also presents a fragment of PAK I, a peptide denoted p37, which contains the catalytic domain of PAK I. The purification, characterization, nucleotide and amino acid sequences of PAK I and p37 are also disclosed. Another aspect of the invention discloses the cytostatic activity of PAK I and its fragments.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: July 29, 2003
    Assignee: The Regents of the University of California
    Inventors: Jolinda A. Traugh, Regina D. Rooney, Rolf Jakobi, Polygena T. Tuazon, Charng-Jui Chen, William E. Meek, Edward J. Carroll, Jr., Curtis A. Monnig
  • Human kinase and polynucleotides encoding the same
    Patent number: 6593126
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: July 15, 2003
    Assignee: Lexicon Genetics Incorporated
    Inventors: Yi Hu, James Alvin Kieke, Gregory Donoho
  • GMP synthetase and gene coding for the same
    Patent number: 6593117
    Abstract: A protein which has a GMP synthetase activity, a DNA which codes for the protein and a transformant which is introduced with the DNA in a form that allows expression of the protein encoded by the DNA.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: July 15, 2003
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hisashi Kawasaki, Yoshihiro Usuda, Yasuhiro Mihara, Osamu Kurahashi
  • Human kinases and polynucleotides encoding the same
    Patent number: 6593125
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: July 15, 2003
    Assignee: Lexicon Genetics Incorporated
    Inventors: Carl Johan Friddle, Erin Hilbun, Brian Mathur, C. Alexander Turner, Jr.
  • Genes encoding proteins involved in mitotic checkpoint control and methods of use thereof
    Patent number: 6593098
    Abstract: Novel human BUB genes and their encoded proteins are provided herein. The kinases encoded by the disclosed BUB1A and BUB1B genes play a pivotal role in mitotic checkpoint control. BUB3 is a substrate of these kinases, BUB genes and their encoded proteins provide valuable therapeutic targets for the design of anti-proliferative agents which inhibit the aberrant cellular proliferation observed in tumor cells.
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: July 15, 2003
    Assignee: Fox Chase Cancer Center
    Inventors: Timothy Yen, Gordon Chan, Sandra Jablonski
  • Human kinase and polynucleotides encoding the same
    Patent number: 6586230
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: July 1, 2003
    Assignee: Lexicon Genetics Incorporated
    Inventors: Yi Hu, Boris Nepomnichy, Brenda Gerhardt, D. Wade Walke, Carl Johan Friddle
  • Polypeptides having peroxidase activity and nucleic acids encoding same
    Patent number: 6586215
    Abstract: The present invention relates to isolated polypeptides having peroxidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: July 1, 2003
    Assignee: Novozymes Biotech, Inc.
    Inventors: Debbie Yaver, Barbara McArdle
  • Method for the production of &rgr;-Hydroxybenzoate in species of pseudomonas and agrobacterium
    Patent number: 6586229
    Abstract: Bacterial strains transformed with the pcu genes are useful for the production of para-hydroxybenzoate (PHBA). Applicant has provided the p-cresol utilizing (pcu) and tmoX gene sequences from Pseudomonas mendocina KR-1, the proteins encoded by these sequences, recombinant plasmids containing such sequences, and bacterial host cells containing such plasmids or integrated sequences. Method for the use of these materials to produce PHBA are also disclosed.
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: July 1, 2003
    Assignee: North Carolina State University
    Inventors: Arie Ben-Bassat, Monica Cattermole, Anthony A. Gatenby, Katharine J. Gibson, M. Isabel Ramos-Gonzalez, Juan Ramos, Sima Sariaslani
  • TAO protein kinases and methods of use therefor
    Patent number: 6586242
    Abstract: Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: July 1, 2003
    Assignee: Board of Regents, The University of Texas System
    Inventors: Melanie H. Cobb, Michele Hutchison, Zhu Chen, Kevin Scott Berman
  • Human kinases and polynucleotides encoding the same
    Patent number: 6579710
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: June 17, 2003
    Assignee: Lexicon Genetics Incorporated
    Inventors: C. Alexander Turner, Jr., Brian Mathur, Carl Johan Friddle
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6579709
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: June 17, 2003
    Assignee: Applera Corporation
    Inventors: Karl Guegler, Ellen M. Beasley, Valentina Di Francesco
  • IKK3 kinase
    Patent number: 6576439
    Abstract: This invention relates to an IKK kinase protein, IKK3, nucleotides coding for it vectors and host cells containing the same and methods for screening for modulators of said IKK3 protein for treatment of conditions involving inflammation.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: June 10, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Yoshihiro Takemoto, Yutaka Sakai, Yasuhiro Hashimoto