Patents Examined by M. Vaughn
  • Novel 5,6,7,8-tetrahydro-5-quinolines and their use as anti-inflammatory agents
    Patent number: 4117135
    Abstract: Pyridine derivatives of the formula ##STR1## wherein R.sub.1 is an alkyl, aliphatic, a cycloalkyl, or a substituted or unsubstituted hydrocarbon aryl and the substituent is halogen, alkoxy or methylenedioxy; R.sub.2 is H or Cl; X is CN, 5-tetrazolyl, or COOH or a carboxylic acid derivative; Y is H, OH, OCOR.sub.7, NH.sub.2, NHCOR.sub.8, R.sub.9, COOH or COOR.sub.10 and R.sub.7, R.sub.8, R.sub.9 and R.sub.10 are alkyl groups of 1-10 carbon atoms; A is methylene or a carbon-to-carbon bond; and R.sub.3 and R.sub.4 are each H or alkyl groups of 1-4 carbon atoms, are useful as anti-inflammatory agents.
    Type: Grant
    Filed: October 8, 1975
    Date of Patent: September 26, 1978
    Assignee: Schering, A.G.
    Inventors: Eberhard Schroder, Henning Koch
  • Oxygenated azatetracyclic compounds
    Patent number: 4112110
    Abstract: 5-Oxygenated azatetracyclic compounds of the formula ##STR1## wherein X represents oxygen or sulphur, R represents a hydroxy group optionally esterified by an alkanecarboxylic acid, and R.sub.1 stands for a lower alkyl, lower alkenyl or allyl, or salts thereof, such compounds having a central-depressant and agitation-inhibiting action connected with cataleptic effects to a very low extent only these properties rendering the new compounds suitable as tranquillizing, antipsychotic and agitation-inhibiting substances.
    Type: Grant
    Filed: November 3, 1976
    Date of Patent: September 5, 1978
    Assignee: Ciba-Geigy Corporation
    Inventor: Hans Blattner
  • Compounds of ergolene and ergoline structure and method for the preparation thereof
    Patent number: 4108855
    Abstract: The invention relates to a novel compound of the formula ##STR1## and the pharmaceuticlly acceptable acid addition salts thereof, wherein R stands for a hydrogen atom or methyl group, x y designates a ##STR2## Q is a hydrogen atom or a benzyloxycarbonyl- or N-tert.-butyloxycarbonyl protective group, and R.sub.1 is the side chain of a natural .alpha.-amino acid selected from the group consisting of Arg--, Tryp-13 , Phe--, Ser--, Leu--, Val--, Meth--, Tyr--, His-- or Prol---side-chain.The compounds according to the invention possess antiserotonin and hypotensive effects and act upon the central nervous system.
    Type: Grant
    Filed: March 2, 1977
    Date of Patent: August 22, 1978
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Erzsebet Mago nee Karacsony, Sandor Bajusz, Jozsef Borsi, Ildiko Kiraly, Endre Csanyi, Istvan Polgari
  • Method for producing N-(4-fluorophenyl)-2,3,-dichloromaleimide
    Patent number: 4010182
    Abstract: N-(4-fluorophenyl)-2,3-dichloromaleimide of uniform grain size is produced either by reacting 2,3-dichloromaleic acid, an anhydride or an ester thereof with 4-fluoroaniline in an aqueous medium or by dehydrative-cyclization of either N-(4-fluorophenyl)-2,3-dichloromaleamic acid or 4-fluoroanilinium 2,3-dichloromaleate in an aqueous medium. The N-(4-fluorophenyl)-2,3-dichloromaleimide of uniform grain size provides improved fungicidal activity and is convenient for preparing an agricultural fungicidal composition.
    Type: Grant
    Filed: May 7, 1975
    Date of Patent: March 1, 1977
    Assignee: Mitsubishi Chemical Industries Ltd.
    Inventors: Kazuo Matsui, Taichiro Shigematsu, Tetsuya Shibahara, Makoto Nakazawa