Patents Examined by M. W. Russell
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Patent number: 5231190Abstract: Squarylium compounds of the formula: ##STR1## wherein Q.sup.1 and Q.sup.2 are each independently a pyrylium, thiopyrylium, selenopyrylium, benzpyrylium, benzthiopyrylium or benzselenopyrylium nucleus, and R.sup.1 and R.sup.2 are each independently an aliphatic or cycloaliphatic group, can be prepared by reacting a squaric acid derivative of the formula: ##STR2## with a compound of the formula Q.sup.2 CH.sub.2 R.sup.2 in the presence of a base. The derivatives of Formula II may be prepared by condensing a 2,3,4,4-tetrahalocyclobut-2-en-1-one with a compound of the formula Q.sup.1 CH.sub.2 R.sup.1 in the presence of a base to produce a compound of the formula: ##STR3## wherein Q.sup.1 and R.sup.1 are as defined above, and X represents chlorine or bromine, and hydrolyzing the compound of Formula III. Alternatively, the derivatives of Formula II may be prepared by reacting a diester, monoacid chloride monoester or diacid chloride of squaric acid with a compound of the formula Q.sup.1 CH.sub.2 R.sup.Type: GrantFiled: May 6, 1991Date of Patent: July 27, 1993Assignee: Polaroid CorporationInventors: Donald A. McGowan, Paulina P. Garcia, John W. Lee, Thomas K. Spencer, Stephen J. Telfer, Michael J. Zuraw
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Patent number: 5228896Abstract: Cyclohexenone oxime ethers of the formula I ##STR1## (R.sup.1 =C.sub.1 -C.sub.6 -alkyl; A=substituted or unsubstituted alkylene or alkenylene;Z=a 5-membered or 6-membered heteroaromatic structure;X=substituted or unsubstituted amino, nitro, cyano, halogen, alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -haloalkoxy, carboxyl, C.sub.1 -C.sub.4 -alkoxycarbonyl, substituted or unsubstituted benzyloxycarbonyl and phenyl;n=0 to 3, or 1 to 4 where Z is halogen-substituted pyridyl; andR.sup.Type: GrantFiled: May 8, 1991Date of Patent: July 20, 1993Assignee: BASF AktiengesellschaftInventors: Ulf Misslitz, Norbert Meyer, Juergen Kast, Norbert Goetz, Albrecht Harreus, Thomas Kuekenhoehner, Bruno Wuerzer, Helmut Walter, Karl-Otto Westphalen, Matthias Gerber
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Patent number: 5220035Abstract: Test compositions, indicators, and test device are provided which are capable of generating different hues at different analyte concentrations. The compositions are capable of generating a yellow hue in situ. Visual tests for clinically important analytes, such as glucose, are determined by use of two independent catalytic systems which are reactive with reduced nicotinamide adenin dinucleotide to produce a range of hues; the particular hue produced depending on the concentration of the analyte. The invention provides a test device for the determination of analyte, e.g. glucose, in body fluid which exhibits a RAINBOW of hues, the particular final hue produced depending on the analyte concentration.Type: GrantFiled: April 18, 1991Date of Patent: June 15, 1993Assignee: Miles Inc.Inventor: James P. Albarella
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Patent number: 5216180Abstract: A herbicidal hydroxyethyl-cyclopropyl-azolyl derivative of the formula ##STR1## in which R.sup.1 represents halogen, phenyl or the grouping --Z-R.sup.3, whereinZ represents oxygen, sulphur, SO or SO.sub.2 andR.sup.3 represents alkyl, phenyl or benzyl,R.sup.2 represents alkenyl, optionally substituted furyl, optionally substituted thienyl or the radical of the formula ##STR2## wherein R.sup.4 represents difluoromethoxy, 1,1,2,2-tetrafluoroethoxy, 1,1,2-trifluoro-2-chloro-ethoxy, cyano, formyl, alkoximinoalkyl, carbalkoxy, dialkoxyalkyl, phenoxyalkyl which is optionally substituted in the phenyl moiety by halogen, or benzyloxy which is optionally substituted in the phenyl moiety by halogen andR.sup.5 represents hydrogen or halogen, orR.sup.4 and R.sup.5 are linked in the ortho-position and together represent --O--CH.sub.2 --O--, orR.sup.2 represents the radical of the formula ##STR3## in which R.sup.6 represents difluoromethoxy, 1,1,2,2-tetrafluoroethoxy or 1,1,2-trifluoro-2-chloro-ethoxy, orR.sup.Type: GrantFiled: November 1, 1991Date of Patent: June 1, 1993Assignee: Bayer AktiengesellschaftInventors: Jurgen Scherkenbeck, Monika Frie, Klaus Stroech, Thomas Himmler, Georg-W. Ludwig, Wilhelm Brandes, Stefan Dutzmann
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Patent number: 5212184Abstract: 1-Carbonyl derivatives of 4-pentafluorophenoxypiperidines and methods for treating convulsions, depression, and hypertension utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: September 16, 1992Date of Patent: May 18, 1993Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Grover C. Helsley, Larry Davis, Gordon E. Olsen
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Patent number: 5204469Abstract: The invention relates to a process for the preparation of the compound of formula ##STR1## wherein a formylating agent is reacted with the compound of formula ##STR2## and wherein the compounds obtained are cyclised in the presence of an acid.Type: GrantFiled: July 3, 1991Date of Patent: April 20, 1993Assignee: SanofiInventors: Marcel Descamps, Joel Radisson
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Patent number: 5201936Abstract: Novel substituted thieno[3,2-b]pyran-5,7-diones of the general formula (I) ##STR1## Processes for their preparation and their use as herbicides and as plant growth regulators and novel intermediates of the formula (VI) ##STR2## (in which R.sup.1, R.sup.2, X, Y and Z have the meaning given in the description).Type: GrantFiled: October 15, 1991Date of Patent: April 13, 1993Assignee: Bayer AktiengesellschaftInventors: Heinz-Jurgen Bertram, Klaus Lurssen, Hans-Joachim Santel, Robert R. Schmidt, Andrew Plant, Bernd-Wieland Kruger, Achim Harder, Norbert Mencke
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Patent number: 5179213Abstract: A process of separating one or more seleced species of ions from a solution containing the ions comprises contacting the solution with a novel composition of matter comprising a hydrocarbon chain covalently bonded to a macrocyclic compound, wherein the macrocyclic compound has at least four --A--C--C-- linkages in which A for each such linkage, is independently selected from the group consisting of O, O--CH.sub.2, S, SH.sub.2, NR, and NRCH.sub.2, with R being independently selected from the group consisting of hydrogen, alkyl and benzyl, and wherein the hydrocarbon chain has an end group ##STR1## with X being independently selected from the group consisting of lower alkyl, benzyl, phenyl, halogen, O--CH.sub.3, O--C.sub.2 H.sub.5 and O-matrix, and with matrix being independently selected from the group consisting of silica, silica gel, glass, glass fibers, titania, zirconia, alumina and nickle oxide.Type: GrantFiled: May 1, 1990Date of Patent: January 12, 1993Assignee: Brigham Young UniversityInventors: Jerald S. Bradshaw, Reed M. Izatt, Virginia B. Christensen, Ronald L. Bruening
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Patent number: 5086189Abstract: Epoxides are manufactured by reacting olefines, such as cyclohexene, isoamylene, alpha-pinene, allyl alcohol, 2,5-dihydrofuran and styrene, with hydrogen peroxide, in a homogeneous liquid reaction mixture containing less than 10% by weight of water, in the presence of a compound of a metal of group 6a, such as selenium dioxide or selenous acid, and of an organic nitrogen-containing base having a pKa of not more than 8, such as pyridine, chloropyridine, collidine, quinoline, isoquinoline or a lutidine.Type: GrantFiled: February 2, 1990Date of Patent: February 4, 1992Assignee: Interox (Societe Anonyme)Inventors: Andre Lecloux, Claude Declerck, Franz Legrand
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Patent number: 5055486Abstract: There are provided certain 13-alkyl-23-imino-LL-F28249 compounds which are useful for controlling endo- and ectoparasites, insects, acarids and nematodes.Type: GrantFiled: December 22, 1989Date of Patent: October 8, 1991Assignee: American Cyanamid CompanyInventors: Timothy C. Barden, Brian L. Buckwalter
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Patent number: 5011953Abstract: Disclosed herein is a method for preparing epichlorohydrins by reacting allyl chlorides with an alkyl hydroperoxide in the presence of a modified catalyst formed by substituting specific substituents for 1 to 50% of the silanol groups of a catalyst having titanium atoms bound to a silicon dioxide carrier via oxygen atoms and having on the same carrier 1 to 6 silanol groups per square nanometer thereof.Type: GrantFiled: November 8, 1989Date of Patent: April 30, 1991Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Takehisa Nakanishi, Eiji Koga, Isao Fukada
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Patent number: 5010099Abstract: Novel lactone compounds having remarkable immunomodulatory and antitumor activities, pharmaceutical compositions comprising such compounds, methods for the preparation of the novel compounds and compositions and methods of their use for therapeutic purposes are described. The new lactone compounds have the structure according to the formula: ##STR1## wherein: R=--H, --A, --CH.sub.2 --Q, --COA or --COZ,A=lower alkyl,Z=monocyclicaryl,Q=phenyl, tolyl or xylyl,X=--H, --A, --Z or --CH.sub.2 --Z, andY=--H, --A, --Z, --CH.sub.2 --Z, --COA, --COZ,the acid-addition salts, the octahydro and 23,24-dihydro derivatives thereof.Type: GrantFiled: May 7, 1990Date of Patent: April 23, 1991Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Malika Gunasekera, Sarath P. Gunasekera, Ross E. Longley, Neal S. Burres
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Patent number: 4999363Abstract: Novel tricyclic compound represented by formula ##STR1## possess a TXA.sub.2 biosynthesis inhibiting activity and/or a TXA.sub.2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.Type: GrantFiled: June 6, 1989Date of Patent: March 12, 1991Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Etsuo Oshima, Hiroyuki Obase, Akira Karasawa, Kazuhiro Kubo, Ichiro Miki, Akio Ishii
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Patent number: 4900754Abstract: Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.Type: GrantFiled: March 27, 1989Date of Patent: February 13, 1990Assignee: Rorer Pharmaceutical Corp.Inventors: John R. Regan, Kent W. Neuenschwander
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Patent number: 4897416Abstract: The present invention relates to novel 5-oximino-13.beta.-carbonylthiomilbemycin derivatives of formula I, to their preparation and to the use thereof for controlling pests. The invention further relates to pesticidal compositions which contain at least one of these compounds as active ingredient. The novel compounds have the general formula I ##STR1## wherein R.sub.1 is hydrogen or an alkyl, cycloalkyl or acyl group,R.sub.2 is methyl, ethyl, isopropyl or sec-butyl, or is the ##STR2## group, wherein X is methyl, ehtyl or isopropyl, and R is hydrogen or an unsubstituted or substituted straight chain or branched C.sub.1 -C.sub.18 alkyl group, an unsubstituted or substituted cycloaliphatic group of 3 to 10 carbon atoms, an unsubstituted or substituted C.sub.2 -C.sub.6 alkenyl group, an unsubstituted or substituted C.sub.2 -C.sub.6 alkynyl group, an unsubstituted or substituted phenyl group or an unsubstituted or substituted benzyl group.Type: GrantFiled: February 8, 1988Date of Patent: January 30, 1990Assignee: Ciba-Geigy CorporationInventors: Bruno Frei, Anthony C. Sullivan
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Patent number: 4804679Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1-3 alkyl, andZ is ##STR2## wherein R.sub.7 is hydrogen, R.sub.8 or M,whereinR.sub.8 is a physiologically acceptable and hydrolyzable ester group, andM is a pharmaceutically acceptable cation,the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.Type: GrantFiled: August 6, 1987Date of Patent: February 14, 1989Assignee: Sandoz Pharm. Corp.Inventor: Paul L. Anderson