Abstract: An intravenous delivery system may have a liquid source containing a liquid, tubing, and an anti-run-dry membrane positioned such that the liquid, flowing form the liquid source to the tubing, passes through the anti-run-dry membrane. The anti-run-dry membrane may have a plurality of pores through which the liquid flows, and may be formed of a hydrophilic material that resists passage of air through the pores. The intravenous delivery system may further have a bubble point raising component that raises the bubble point of the anti-run-dry membrane. The bubble point raising component may, in some embodiments, be a high surface energy coating or additive.

Abstract: The processes for inserting fluid under the skin of a patient using a safety syringe assembly include initially locating an up-alignment marker. The marker is aligned with a bevel in the needle of the safety syringe assembly so the orientation of the needle bevel is always known by the medical professional, even when the needle bevel cannot be seen. The needle is inserted bevel up prior to insertion. Once inserted, the medical professional inverts the safety syringe assembly so that the bevel is down. This is done by merely flicking the wrist of the hand holding the safety syringe assembly. This prevents splash back of any body fluids from the patient to the medical professional. The same safety syringe assembly and the same process are used for withdrawing fluids from the body of the patient.

Abstract: A needle tube having a needle tip for puncturing skin; a needle hub; and a fluid-draining portion for enabling draining of a medicine. The needle hub includes: a retention part (first member) for retaining the needle tube; an insertion part into which the output portion of a syringe is inserted; and a flange-like skin contact portion that is disposed in a manner so as to cover an area surrounding the needle tube and makes contact with and/or faces the skin when a living body is punctured with the needle tube. The fluid-draining portion is disposed in the skin contact portion of the needle hub and enables a user to drain the medicine that has spilled when removing air and is held in the skin contact portion.

Abstract: A medical connector includes: a body member that partitions a flow path between a proximal side opening and a distal side opening; and a male connector connection portion including: a valve body facing the flow path, and a male connector connection port openable and closable by the valve body. The body member comprises a male connector housing portion configured to house a distal end portion of a male connector connected to the male connector connection portion. The male connector housing portion is configured to cause the male connector to communicate with the distal side opening and to prevent inflow of a fluid from the proximal side opening to the male connector housing portion by connection of the male connector to the male connector connection portion.

Abstract: In some examples, a fluid delivery device is described. The fluid deliver device includes a housing; a reservoir disposed within the housing, the fluid reservoir defining a fluid outlet at a first end of the fluid reservoir; a plunger assembly disposed within the fluid reservoir, the plunger assembly including a friction clutch; and a seal engaged with an interior surface of the fluid reservoir to prevent movement of a material within the fluid reservoir past the seal; and a motive element in communication with a first end of the plunger assembly and configured to apply a motive force on the first end of the plunger assembly towards the first end of the fluid reservoir, wherein the friction clutch is configured to apply a frictional force to the interior surface of the fluid reservoir to resist the motive force, and wherein operation of the friction clutch enables motive force to overcome the frictional force to allow the plunger assembly to translate towards the first end of the fluid reservoir.

Abstract: A drug delivery device for setting and dispensing a dose of a drug is presented having a support body having a first end defining a first opening and a second end defining a second opening and a centered outer indicator ring. A syringe barrel sealed by a stopper is slidably diposed therein along an axial direction and adapted to have an integrated needle or to be coupled with a needle assembly, wherein the syringe barrel is positioned within the support body. A needle shield is adapted to be coupled to one of the ends of the support body and slidably disposed thereon. An outer body is adapted to be coupled to the other end of the support body and slidably disposed thereon, wherein the outer indicator ring limits the movement of the outer body as well as of the needle shield.

Abstract: A syringe assembly for use as a pre-filled syringe is disclosed. The syringe assembly includes a syringe barrel defining a chamber and having a stopper disposed therein. A plunger rod includes an inner member engaged with a portion of the stopper and an outer member adapted for rotational advancement with respect to the inner member to axially displace the outer member with respect to the inner member. The plunger rod is transitionable from a collapsed position in which a portion of the inner member is nested within the outer member, to an extended position in which the same portion of the inner member extends outside the outer member. The inner member includes a radial extension and the outer member defines a helical track adapted to receive the radial extension therein.

Abstract: A method and apparatus are provided for use in locating a target region which is situated in the body of a subject, for example for the delivery of drugs. The system includes an assembly for controlling the flow of fluid from a fluid reservoir to a conduit, such as a needle. A sensor detects a characteristic indicative of the fluid pressure in the conduit. The system processes data from the sensor to detect the presence of a pulsatile waveform. A controller may control further operation of the system based on information regarding the presence of the pulsatile waveform and features of the waveform, such as amplitude.

Abstract: An automated blood glucose control system is configured to generate a backup therapy protocol comprising insulin therapy instructions derived from autonomously determined doses of insulin. The system generates a dose control signal using a control algorithm configured to autonomously determine doses of insulin to be infused into a subject for the purpose of controlling blood glucose of the subject based at least in part on a glucose level signal received from a glucose sensor. The system can track insulin therapy administered to the subject over a tracking period, including storing an indication of the autonomously determined doses of insulin delivered to the subject as basal insulin, as correction boluses of insulin, or as mealtime boluses of insulin. The system can generate a backup injection therapy protocol or a backup pump therapy protocol with insulin therapy instructions based at least in part on the insulin therapy administered to the subject over the tracking period.

Abstract: A syringe assembly including a syringe barrel defining a chamber having a stopper therein is disclosed. The syringe assembly includes a plunger rod associated with the stopper, the plunger rod includes an outer sleeve having a distal end interconnected to the stopper and a sidewall portion defining an opening therein. The plunder rod also includes an inner sleeve disposed within the outer sleeve including a longitudinally extending track in alignment with the opening in the outer sleeve. The inner sleeve is adapted for telescopic movement with respect to the outer sleeve. The plunger rod also includes a spring mounted in association with the inner sleeve. The syringe assembly further includes a holding mechanism associated with the plunger rod and configured for cooperation with the inner and outer sleeves. Relative movement between the inner and outer sleeves causes the plunger rod to transition from a collapsed position to an extended position.

Abstract: Embodiments of the invention described herein include low cost infusion devices having basal and/or bolus fluid delivery options. Embodiments of the device include a housing, a reservoir to contain the fluid, a source of pressure to exert a force to expel the fluid contained in the reservoir, a bolus port adapted to receive an optional extra dose of fluid, and a cannula in fluid communication with the reservoir and the bolus port. The cannula is adapted for insertion into the user's skin for delivery of the fluid to the user's body. The device can provide a continuous delivery of the fluid along a first fluid flow path from the reservoir to the cannula and the optional extra dose of fluid along a second fluid flow path from the bolus port to the cannula.

Abstract: An infusion device (1) for administering a medical fluid to a patient (P) comprises a pumping mechanism (11) for exerting a force onto a delivery set (2, 3) for delivering a medical fluid from the delivery set towards a patient (P), a sensor device (14) for measuring the force exerted on the delivery set (2, 3) by the pumping mechanism (11), the sensor device (14) being constituted to output a sensor signal indicative of the force exerted onto the delivery set (2, 3), and a processor device (15) for controlling operation of the infusion device (1). Herein, the processor device (15) is constituted to perform a diagnosis routine during which a sensor signal of the sensor device (14) is obtained and compared to an expected sensor signal, to allow for detecting a drift in the sensor signal of the sensor device (14).

Abstract: Catheters, sheaths, or other tubular devices are provided that include a proximal end, a distal end sized for introduction into a patient's body, and a steerable distal portion. The tubular device includes a primary lumen extending between the proximal and distal ends; an auxiliary lumen adjacent the primary lumen; and one or more reinforcement members including windings extending helically along at least the distal portion, at least some of the windings passing between the primary and steering element lumens and at least some of the windings surrounding both the primary and steering element lumens. In one embodiment, a steering element is slidably disposed within the auxiliary lumen. Apparatus and methods for making such tubular devices are also provided.

Abstract: Apparatus and methods for inserting a medicament into a body cavity are described. The apparatus comprises an elongate tube with a plunger rod therein. The plunger rod has at least one projection which cooperatively interacts or engages with at least one discontinuity on the inside of the elongate tube so that proximal movement of the plunger rod with respect to the elongate tube expels the medicament into the body cavity.

Abstract: A digital biomedical device includes a substrate forming a reservoir, a membrane comprising a first layer and a second layer having a strain therebetween, the membrane sealing the reservoir, and a controller configured to activate the membrane and release at least a portion of the strain causing the membrane curl and open the reservoir.

Abstract: A method of treating a patient by implanting a system comprising an infusion device for injecting a substance, at least one reservoir comprising at least one compartment which accommodates and preserves the substance to be injected, and an active cooling device adapted to cool the reservoir and thereby keep the substance within said at least one compartment of the reservoir at a temperature below 37° C. The method comprises the steps of: cutting the skin, dissecting free at least one area within the patient's body, placing the infusion device and the at least one reservoir inside the patient's body along with the cooling device, such that the at least one reservoir is in fluid connection with the infusion device to supply to the infusion device the substance to be injected into the patient's body, and closing at least the skin after implantation of at least parts of the system.

Abstract: An injection device is presented having a housing, a container holder, a first and a second energy accumulating member arranged in the interior of the housing adapted to accumulate and store energy, a sleeve, a plunger holder operationally associated with said first energy accumulating member such that the plunger holder and the container holder are axially moveable in relation to the housing a predetermined distance towards the proximal end of the injection device from an initial position to a position following needle penetration, and a plunger rod being operationally associated with said second energy accumulating member such that the plunger rod is axially moveable in relation to the container holder, wherein in the initial position movement of the plunger holder is substantially inhibited by at least one first biasable member that recoils when being overlapped by an opening and/or recess of the sleeve such that the plunger holder is released.

Abstract: A syringe protecting device equipped with an outer cylinder, an inner cylinder and a spring, wherein, when the spring is released from its compressed state, the inner cylinder is moved rearward with respect to the outer cylinder so that a syringe needle is stored inside the outer cylinder, and the syringe protecting device further equipped with a releasable pre-locking mechanism for fixing the inner cylinder to the outer cylinder while maintaining the spring in the compressed state in the front-rear direction, wherein, the pre-locking mechanism fixes the inner cylinder before movement to the outer cylinder by engaging the protruding sections of the ring with the engaging sections of the through groove sections.

Abstract: An implantable portal includes a septum that has embedded therein an indicia adapted to identify at least one characteristic of the portal. The indicia may be formed as an impression at a base layer of the septum, and is filled with a radiopaque material. The septum base layer is covered by liquid silicone, which bonds with the septum base layer when solidified, so that an integral one-piece septum, with the identifier indicia embedded therein, is effected. The indicia embedded septum is fitted to the reservoir housing of the portal for providing identification information for that portal. The septum embedded indicia is viewable visually and also by x-ray or computer tomography imaging.

Abstract: An intravenous delivery system may have a liquid source containing a liquid, tubing, and an anti-run-dry membrane positioned such that the liquid, flowing form the liquid source to the tubing, passes through the anti-run-dry membrane. The anti-run-dry membrane may be positioned within an exterior wall of a drip unit, and may be secured to a seat of the exterior wall by an attachment component. The attachment component may have various forms, such as a secondary exterior wall that cooperates with the exterior wall to define a drip chamber, a washer positioned such that the anti-run-dry membrane is between the washer and the seat, and an adhesive ring formed of a pressure sensitive adhesive and secured to the anti-run-dry membrane and the seat via compression. Interference features may protrude inward from the exterior wall or outward from the anti-run-dry membrane to help keep the anti-run-dry membrane in place.